The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.
Open accessAbstract
Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the concentration of an inhibitor such as Colcemid. Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells. The potential uses of the system as an immunologically tolerated "tissue" for wound healing and as a model for studying fibroblast function are discussed.
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Citations
Cites
Granulation tissue as a contractile organ
Gabbiani, G., Hirschel, B. J., Ryan, G. B., Statkov, P. R., & Majno, G. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.135.4.719 · Cited by 807
Cited by
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594
Connective tissue morphogenesis by fibroblast traction
Stopak, D., & Harris, A. K. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90388-8 · Cited by 586
Montesano, R., & Orci, L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4894 · Cited by 561
Metadata
- Authors
- Bell, E., Ivarsson, B., & Merrill, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-03
- Volume
- 76
- Issue
- 3
- Pages
- 1274-1278
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1984729535
- Cited by
- 2,067
- References
- 1
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Bell, E., Ivarsson, B., & Merrill, C. (1979). Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.3.1274
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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