The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).
Open accessAbstract
Neoplastic transformation of cell by avian sarcoma virus is mediated by a single viral gene (src), which encodes a phosphoprotein (pp60src) with the enzymatic activity of a protein kinase. The DNAs of vertebrate species contain a highly conserved homologue of src that is also represented in the polysomal RNA of uninfected cells and, hence, may specify a normal cellular protein. We have used antisera directed against pp60src to isolate a closely related phosphoprotein (denoted vertebrate pp60) from uninfected chicken, quail, rat, and human cells. Our data indicate that vertebrate pp60 is a homologue of pp60src, highly conserved both antigenically and chemically. Moreover, the cellular protein may possess protein kinase activity similar to that associated with pp60src. We conclude that the product of src is a slightly modified analogue of a normal cellular protein.
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Cites
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DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
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Protein kinase activity associated with the avian sarcoma virus src gene product.
Collett, M. S., & Erikson, R. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.4.2021 · Cited by 1,105
Identification of a transformation-specific antigen induced by an avian sarcoma virus
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Self-citationCell Membrane Antigen Isolation with the Staphylococcal Protein A-Antibody Adsorbent
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Identification of a polypeptide encoded by the avian sarcoma virus src gene.
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Self-citation
Cited by
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses
Lipsich, L. A., Lewis, A. J., & Brugge, J. S. (1983) · Journal of Virology · doi:10.1128/jvi.48.2.352-360.1983 · Cited by 494
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Lipid rafts: signaling and sorting platforms of cells and their roles in cancer
Staubach, S., & Hanisch, F.-G. (2011) · Expert Review of Proteomics · doi:10.1586/epr.11.2 · Cited by 284
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Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design
Hie, B., Bryson, B. D., & Berger, B. (2020) · Cell Systems · doi:10.1016/j.cels.2020.09.007 · Cited by 154
“…kinase involved in Toll-like receptor signaling (Kawagoe et al., 2007); human c-SRC, a tyrosine kinase and canonical proto-oncogene (Oppermann et al., 1979); human p110 d , a lipid kinase and leukocytic immune regulator (Vanhaesebroeck et al., 1997); and Mtb PknB, a…”
Background
Metadata
- Authors
- Oppermann, H., Levinson, A. D., Varmus, H. E., Levintow, L., & Bishop, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-04
- Volume
- 76
- Issue
- 4
- Pages
- 1804-1808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026299485
- Cited by
- 375
- References
- 17
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Oppermann, H., Levinson, A. D., Varmus, H. E., Levintow, L., & Bishop, J. M. (1979). Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.4.1804
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
