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Cited by 301

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Induction of a basement membrane glycoprotein in embryonic kidney: possible role of laminin in morphogenesis.

Open access
Ekblom, P, Alitalo, K, Vaheri, A, Timpl, R, Saxén, L·1980·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.77.1.485
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Abstract

The glycoprotein laminin is found exclusively in the basement membranes of adult tissues, not in the mesenchymal stroma. We studied the appearance and distribution of laminin during the early formation of kidney tubules in mouse embryos and in an in vitro transfilter model system. In immunofluorescence using affinity-purified antibodies, the distribution of laminin showed a clear correlation, both spatially and temporally, to the early stages of tubule formation. In vivo, laminin was first detected in a punctate pattern in areas where the pretubular aggregates form; later, it became confined to the basement membranes of the tubules. In experiments in vitro, the nephrogenic mesenchyme was found to form tubules after 12-24 hr of transfilter contact with the inductor. The first laminin spots were found after 12 hr of culture, 24 hr before overt morphogenesis. As the mesenchymal cells began to aggregate and elongate (at 36 hr), laminin was detected in those cells destined to become epithelial, and at 48 hr it was not found in cells remaining in the stroma. In more mature tubules (at 72 hr), laminin was seen as a sharp band in the basement membranes. It is suggested that laminin is involved in the increased cell adhesiveness during the early aggregation of the nephrogenic mesenchyme.

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Metadata

Authors
Ekblom, P., Alitalo, K., Vaheri, A., Timpl, R., & Saxén, L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1980-01
Volume
77
Issue
1
Pages
485-489
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.77.1.485
OpenAlex
W2019418878
Cited by
301
References
11
FWCI
12.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Induction of a basement membrane glycoprotein in embryonic kidney: possible role of laminin in morphogenesis. https://app.cochat.ai/papers/10.1073/pnas.77.1.485
The paper
Ekblom, P., Alitalo, K., Vaheri, A., Timpl, R., & Saxén, L. (1980). Induction of a basement membrane glycoprotein in embryonic kidney: possible role of laminin in morphogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.1.485

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.