The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A murine tumor producing a matrix of basement membrane.
Open accessAbstract
We have studied a murine tumor previously classified as a poorly differentiated chondrosarcoma. Although the cells in this tumor are surrounded by large quantities of extracellular matrix material, the matrix fails to react with stains specific for the sulfated glycosaminoglycans present in normal cartilage. Here we show at the ultrastructural level that the tumor matrix is a homogeneous, nonfibrillar material, resembling basement membrane. Neither the proteoglycan matrix granules nor collagen fibrils characteristic of cartilage are present in the tumor matrix. Amino acid analyses of whole tumor tissue, enzyme-solubilized tumor components, and the protein extracted from lathyritic tumors confirmed that the tumor matrix is a basement membrane collagen. The collagenous protein extracted from the tumor by nonenzymatic means contains three unique polypeptides larger than the alpha-chain components of the other types of collagen. These studies indicate that the tumor is not a type of chondrosarcoma but a basement membrane producing tumor.
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Citations
Cites
The specific interaction of hyaluronic acid with cartilage proteoglycans.
HARDINGHAM, T., & MUIR, H. (1972) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(72)90160-2 · Cited by 645
Cited by
Laminin–a glycoprotein from basement membranes
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 2,378
Self-citationMetastatic potential correlates with enzymatic degradation of basement membrane collagen
Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I., Foltz, C. M., & Shafie, S. (1980) · Nature · doi:10.1038/284067a0 · Cited by 1,768
Matrigel: Basement membrane matrix with biological activity
Kleinman, H. K., & Martin, G. R. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.004 · Cited by 1,673
Self-citationMatrigel: A complex protein mixture required for optimal growth of cell culture
Hughes, C. S., Postovit, L. M., & Lajoie, G. A. (2010) · PROTEOMICS · doi:10.1002/pmic.200900758 · Cited by 1,534
Basement membrane complexes with biological activity
Kleinman, H. K., McGarvey, M. L., Hassell, J. R., Star, V. L., Cannon, F. B., Laurie, G. W., & Martin, G. R. (1986) · Biochemistry · doi:10.1021/bi00350a005 · Cited by 1,502
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Metadata
- Authors
- Orkin, R. W., Gehron, P., McGoodwin, E. B., Martin, G. R., Valentine, T., & Swarm, R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-01-01
- Volume
- 145
- Issue
- 1
- Pages
- 204-220
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2113127961
- Cited by
- 630
- References
- 1
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Orkin, R. W., Gehron, P., McGoodwin, E. B., Martin, G. R., Valentine, T., & Swarm, R. (1977). A murine tumor producing a matrix of basement membrane. The Journal of experimental medicine. https://doi.org/10.1084/jem.145.1.204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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