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Autoantibody to centromere (kinetochore) in scleroderma sera.
Open accessAbstract
Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.
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Cited by
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Shen, W. H., Balajee, A. S., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., & Yin, Y. (2007) · Cell · doi:10.1016/j.cell.2006.11.042 · Cited by 979
A Molecular View of Kinetochore Assembly and Function
Musacchio, A., & Desai, A. (2017) · Biology · doi:10.3390/biology6010005 · Cited by 544
What do human micronuclei contain?
Norppa, H. (2003) · Mutagenesis · doi:10.1093/mutage/18.3.221 · Cited by 389
CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate
Saitoh, H., Tomkiel, J., Cooke, C. A., Ratrie, H., Maurer, M., Rothfield, N. F., & Earnshaw, W. C. (1992) · Cell · doi:10.1016/0092-8674(92)90538-n · Cited by 346
NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae.
Goh, P. Y., & Kilmartin, J. V. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.3.503 · Cited by 264
Metadata
- Authors
- Moroi, Y., Peebles, C., Fritzler, M. J., Steigerwald, J., & Tan, E. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-03
- Volume
- 77
- Issue
- 3
- Pages
- 1627-1631
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081761746
- Cited by
- 729
- References
- 0
- FWCI
- 20.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Autoantibody to centromere (kinetochore) in scleroderma sera. https://app.cochat.ai/papers/10.1073/pnas.77.3.1627
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- Moroi, Y., Peebles, C., Fritzler, M. J., Steigerwald, J., & Tan, E. M. (1980). Autoantibody to centromere (kinetochore) in scleroderma sera. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.3.1627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
