The DOI matches its Crossref record; 368 of the 368 references it cites were found in a registry or an index.
A Molecular View of Kinetochore Assembly and Function
Open accessAbstract
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters. Kinetochores also control feedback mechanisms responsible for the correction of incorrect microtubule attachments, and for the coordination of chromosome attachment with cell cycle progression. Finally, kinetochores contribute to their own preservation, across generations, at the specific chromosomal loci devoted to host them, the centromeres. They achieve this in most species by exploiting an epigenetic, DNA-sequence-independent mechanism; notable exceptions are budding yeasts where a specific sequence is associated with centromere function. In the last 15 years, extensive progress in the elucidation of the composition of the kinetochore and the identification of various physical and functional modules within its substructure has led to a much deeper molecular understanding of kinetochore organization and the origins of its functional output. Here, we provide a broad summary of this progress, focusing primarily on kinetochores of humans and budding yeast, while highlighting work from other models, and present important unresolved questions for future studies.
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Cites
ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex
Mizuguchi, G., Shen, X., Landry, J., Wu, W.-H., Sen, S., & Wu, C. (2004) · Science · doi:10.1126/science.1090701 · Cited by 1,309
The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore
Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M., & Desai, A. (2006) · Cell · doi:10.1016/j.cell.2006.09.039 · Cited by 994
Self-citationMolecular architecture of the kinetochore–microtubule interface
Cheeseman, I. M., & Desai, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2310 · Cited by 915
Self-citationEarnshaw, W. C., & Rothfield, N. (1985) · Chromosoma · doi:10.1007/bf00328227 · Cited by 842
Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse
Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R. R., et al. (2009) · Science · doi:10.1126/science.1178158 · Cited by 822
Isolation of a yeast centromere and construction of functional small circular chromosomes
Clarke, L., & Carbon, J. (1980) · Nature · doi:10.1038/287504a0 · Cited by 795
The molecular biology of spindle assembly checkpoint signaling dynamics.
Musacchio, A. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.051 · Cited by 778
Self-citationKinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1
DeLuca, J. G., Gall, W. E., Ciferri, C., Cimini, D., Musacchio, A., & Salmon, E. D. (2006) · Cell · doi:10.1016/j.cell.2006.09.047 · Cited by 747
Self-citationThe human CENP-A centromeric nucleosome-associated complex
Foltz, D. R., Jansen, L. E. T., Black, B. E., Bailey, A. O., Yates, J. R., & Cleveland, D. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1397 · Cited by 731
Autoantibody to centromere (kinetochore) in scleroderma sera.
Moroi, Y., Peebles, C., Fritzler, M. J., Steigerwald, J., & Tan, E. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1627 · Cited by 729
Cited by
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Yatskevich, S., Muir, K. W., Bellini, D., Zhang, Z., Yang, J., Tischer, T., Predin, M., Dendooven, T., McLaughlin, S. H., & Barford, D. (2022) · Science · doi:10.1126/science.abn3810 · Cited by 120
PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer
(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93
Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere
Dendooven, T., Zhang, Z., Yang, J., McLaughlin, S. H., Schwab, J., Scheres, S. H. W., Yatskevich, S., & Barford, D. (2023) · Science Advances · doi:10.1126/sciadv.adg7480 · Cited by 58
Structure of the human outer kinetochore KMN network complex
Yatskevich, S., Yang, J., Bellini, D., Zhang, Z., & Barford, D. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01249-y · Cited by 42
(2022) · doi:10.15252/embj.2021110411 · Cited by 40
Metadata
- Authors
- Musacchio, A., & Desai, A.
- Venue
- Biology
- Publisher
- MDPI AG
- Published
- 2017-01-24
- Volume
- 6
- Issue
- 1
- Pages
- 5
- ISSN
- 2079-7737 (ISSN-L)
- OpenAlex
- W2582965622
- Cited by
- 544
- References
- 368
- FWCI
- 26.25
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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