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Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

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Foote, S L, Aston-Jones, G, Bloom, F E·1980·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.77.5.3033PMC PMC349541

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Abstract

By means of extracellular recordings, individual norepinephrine-containing neurons in the locus coeruleus of unanesthetized behaviorally responsive rats and squirrel monkeys were found to respond to specific sensory and behavioral conditions. In rats, distinct clusters of action potentials followed the presentation of various nonnoxious auditory, visual, or somatosensory stimuli at latencies of 15-60 msec. Increased discharge rates were also seen during periods of spontaneous electroencephalogram arousal in both species. In monkeys, these cells responded most vigorously to complex arousing stimuli such as a preferred food. Because the noradrenergic innervation of most forebrain regions arises from the locus coeruleus, these results allow prediction of situations under which this massive projection system would be active and suggest a physiological role for this chemically identified network in specific behavioral processes.

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[19]Foote, S. & Bloom, F. (1979) in Catecholamines: Basic and Clinical Frontiers, eds. Usdin, E., Kopin, I. & Barchas, J. (Pergamon, Elmsford, NY), pp. 625–627.
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Authors: Foote, S. L., Aston-Jones, G., & Bloom, F. E.
Affiliations: Salk Institute for Biological Studies (US)
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1980-05
Volume: 77
Issue: 5
Pages: 3033-3037
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.77.5.3033
PMC: PMC349541
OpenAlex: W2016014417
Cited by: 857
References: 22
Citations by year: 2026: 16 · 2025: 13 · 2024: 18 · 2023: 29 · 2022: 28 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 22 · 2013: 19 · 2012: 25
FWCI: 4.34
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, noradrenergic neurons, neuronal firing rate, sensory stimulation, arousal, auditory stimuli, visual stimuli, somatosensory stimuli, food reward, rats, squirrel monkey
MeSH terms: Action Potentials, Adrenergic Fibers, Animals, Haplorhini, Arousal, Auditory Perception, Evoked Potentials, Locus Coeruleus, Male, Nociceptors, Norepinephrine, Sleep, Visual Perception, Wakefulness, Rats

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Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

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