Cited by 857Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness ResearchNeuroscience of respiration and sleep

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

Open access

Foote, S L, Aston-Jones, G, Bloom, F E·1980·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.77.5.3033PMC PMC349541

Open this paper in CoChat — free account

Abstract

By means of extracellular recordings, individual norepinephrine-containing neurons in the locus coeruleus of unanesthetized behaviorally responsive rats and squirrel monkeys were found to respond to specific sensory and behavioral conditions. In rats, distinct clusters of action potentials followed the presentation of various nonnoxious auditory, visual, or somatosensory stimuli at latencies of 15-60 msec. Increased discharge rates were also seen during periods of spontaneous electroencephalogram arousal in both species. In monkeys, these cells responded most vigorously to complex arousing stimuli such as a preferred food. Because the noradrenergic innervation of most forebrain regions arises from the locus coeruleus, these results allow prediction of situations under which this massive projection system would be active and suggest a physiological role for this chemically identified network in specific behavioral processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.77.5.3033

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Applied Nonparametric Statistics
Wozniak, P. J., & Daniel, W. W. (1991) · Technometrics · doi:10.2307/1268795 · Cited by 5,008
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238
Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.
Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety
Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662
The locus coeruleus: A cytoarchitectonic, golgi and immunohistochemical study in the albino rat
Swanson, L. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90207-9 · Cited by 518
The locus coeruleus: neurobiology of a central noradrenergic nucleus
Amaral, D. G., & Sinnamon, H. M. (1977) · Progress in Neurobiology · doi:10.1016/0301-0082(77)90016-8 · Cited by 497
Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex
Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458
Self-citation
Noradrenergic neurons: Morphine inhibition of spontaneous activity
Korf, J., Bunney, B. S., & Aghajanian, G. K. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90045-4 · Cited by 432
Neuronal activity during the sleep-waking cycle
Steriade, M., & Hobson, J. A. (1976) · Progress in Neurobiology · doi:10.1016/0301-0082(76)90013-7 · Cited by 386
Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
Cedarbaum, J. M., & Aghajanian, G. K. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90398-3 · Cited by 382

Flagged first, then by citations

Show all 22 references

Research works printed but not linked: 3

[19]Foote, S. & Bloom, F. (1979) in Catecholamines: Basic and Clinical Frontiers, eds. Usdin, E., Kopin, I. & Barchas, J. (Pergamon, Elmsford, NY), pp. 625–627.
[20]Jones, G., Segal, M., Foote, S. & Bloom, F. (1979) in Catecholamines: Basic and Clinical Frontiers, eds. Usdin, E., Kopin, I. & Barchas, J. (Pergamon, Elmsford, NY), pp. 643–645.
[21]Siegel, S. (1956) Nonparametric Statistics (McGraw-Hill, New York).

Sorted by citations

Items 401–500 of 851

On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists
Pattij, T., Schetters, D., Schoffelmeer, A. N. M., & van Gaalen, M. M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2405-2 · Cited by 47
Individual differences in the locus coeruleus-norepinephrine system: Relevance to stress-induced cardiovascular vulnerability
Wood, C. S., Valentino, R. J., & Wood, S. K. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.07.008 · Cited by 45
Release of cortical catecholamines by visual stimulation requires activity in thalamocortical afferents of monkey and cat
Marrocco, R. T., Lane, R., McClurkin, J. W., Blaha, C. D., & Alkire, M. T. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02756.1987 · Cited by 46
Stress modulation of reconsolidation
Akirav, I., & Maroun, M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2887-6 · Cited by 46
Methylphenidate Enhances Noradrenergic Transmission and Suppresses Mid- and Long-Latency Sensory Responses in the Primary Somatosensory Cortex of Awake Rats
Drouin, C., Page, M. E., & Waterhouse, B. D. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01310.2005 · Cited by 45
α-Adrenergic Receptor Function, Arousal and Sleep: Mechanisms and Therapeutic Implications
Broese, M., Riemann, D. W., Hein, L., & Nissen, C. (2012) · Pharmacopsychiatry · doi:10.1055/s-0031-1299728 · Cited by 44
Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation
Ogg, M. C., Ross, J. M., Bendahmane, M., & Fletcher, M. L. (2018) · Nature Communications · doi:10.1038/s41467-018-04371-w · Cited by 45
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
García‐Junco‐Clemente, P., Tring, E., Ringach, D. L., & Trachtenberg, J. T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.005 · Cited by 46
What’s That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease
Kelberman, M. A., Keilholz, S. D., & Weinshenker, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583421 · Cited by 46
State-Related Activity, Reactivity of Locus Ceruleus Neurons in Behaving Monkeys
Rajkowski, J., Kubiak, P., Ivanova, S. А., & Aston‐Jones, G. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60854-6 · Cited by 44
Self-citation
Conditioned changes in the basal forebrain: Relations with learning-induced cortical plasticity
Maho, C., Hars, B., Edeline, J., & Hennevin, E. (1995) · Psychobiology · doi:10.3758/bf03327054 · Cited by 48
Noradrenergic modulation of vicarious trial-and-error behavior during a spatial decision-making task in rats
Amemiya, S., Noji, T., Kubota, N., Nishijima, T., & Kita, I. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.031 · Cited by 45
Noradrenergic Control of Gene Expression and Long-Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
Velho, T., Lu, K., Ribeiro, S. T. G., Pinaud, R., Vicario, D. S., & Mello, C. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036276 · Cited by 43
Neuromodulation of decision and response selection
Usher, M., & Davelaar, E. J. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00054-0 · Cited by 43
ADHD: Current Concepts On Etiology, Pathophysiology, and Neurobiology
Jensen, P. S. (2000) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30107-x · Cited by 43
Discharge properties of presumed cholinergic and noncholinergic laterodorsal tegmental neurons related to cortical activation in non-anesthetized mice
Sakai, K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.032 · Cited by 42
Sleep–wake regulation in preterm and term infants
Georgoulas, A., Jones, L., Laudiano‐Dray, M. P., Meek, J. H., Lorenzo Fabrizi, D., & Whitehead, K. (2020) · SLEEP · doi:10.1093/sleep/zsaa148 · Cited by 42
Compound Stimulus Presentation and the Norepinephrine Reuptake Inhibitor Atomoxetine Enhance Long-Term Extinction of Cocaine-Seeking Behavior
Janak, P. H., Bowers, M. S., & Corbit, L. H. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.281 · Cited by 42
[18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's disease
Hilker, R., Razai, N., Ghaemi, M., Weisenbach, S., Rudolf, J., Szelies, B., & Heiss, W. (2003) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(03)00058-1 · Cited by 42
BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain
Matsunaga, W., Shirokawa, T., & Isobe, K. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00093-9 · Cited by 42
Psychological stress increases arousal through brain corticotropin-releasing hormone without significant increase in adrenocorticotropin and catecholamine secretion
Shibasaki, T., Imaki, T., Hotta, M., LING, N. C., & Demura, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90430-u · Cited by 42
Correlation between Cortical State and Locus Coeruleus Activity: Implications for Sensory Coding in Rat Barrel Cortex
Fazlali, Z., Ranjbar‐Slamloo, Y., Adibi, M., & Arabzadeh, E. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00014 · Cited by 39
Cortical connections of striate and extrastriate visual areas in tree shrews
Lyon, D. C., Jain, N., & Kaas, J. H. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981109)401:1 · Cited by 78
Reciprocal cross-desensitization of locus coeruleus electrophysiological responsivity to corticotropin-releasing factor and stress
Conti, L. H., & Foote, S. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00175-8 · Cited by 41
Self-citation
Electrophysiological action of ethanol at the cellular level
Bloom, F. E., & Siggins, G. R. (1987) · Alcohol · doi:10.1016/0741-8329(87)90031-0 · Cited by 41
Self-citation
Shyness and olfactory threshold
Herberner, E. S., Kagan, J., & Cohen, M. (1989) · Personality and Individual Differences · doi:10.1016/0191-8869(89)90079-2 · Cited by 41
Pharmacological Stimulation of Locus Coeruleus Reveals a New Antipsychotic-Responsive Pathway for Deficient Sensorimotor Gating
Alsene, K. M., & Bakshi, V. P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.47 · Cited by 38
Monoaminergic Innervation of Cingulate Cortex
Crino, P. B., Morrison, J. H., & Hof, P. R. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6704-6_10 · Cited by 39
Sleep disturbance produced by electrical stimulation of the locus coeruleus in a human subject
Kaitin, K. I., Bliwise, D. L., Gleason, C. A., Nino‐Murcia, G., Dement, W. C., & Libet, B. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90235-0 · Cited by 39
Brain corticotropin-releasing hormone increases arousal in stress
Shibasaki, T., Yamauchi, N., Hotta, M., Imaki, T., Oda, T., LING, N. C., & Demura, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90216-i · Cited by 39
Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity
Bowyer, J. F., & Hanig, J. P. (2014) · Temperature · doi:10.4161/23328940.2014.982049 · Cited by 38
The pupil: a window on social automatic processing in autism spectrum disorder children
Aguillon-Hernandez, N., Mofid, Y., Latinus, M., Roché, L., Bufo, M. R., Lemaire, M., Malvy, J., Martineau, J., Wardak, C., & Bonnet‐Brilhault, F. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13170 · Cited by 40
Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.
Berridge, C. W., & O'Neill, J. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.1.165 · Cited by 38
In vivo voltammetric monitoring of noradrenaline release and catecholamine metabolism in the hypothalamic paraventricular nucleus
Mermet, C. C., & Gonon, F. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90301-5 · Cited by 38
Physiological interactions of the basic rest - activity cycle of the brain: Pulsatile luteinizing hormone secretion as a model
Rasmussen, D. D. (1986) · Psychoneuroendocrinology · doi:10.1016/0306-4530(86)90001-6 · Cited by 38
Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice
Wang, F., Wang, W., Gu, S., Qi, D., Smith, N., Peng, W., Dong, W., Yuan, J., Zhao, B.-B., Mao, Y. Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37974-z · Cited by 37
Locus Coeruleus Optogenetic Light Activation Induces Long-Term Potentiation of Perforant Path Population Spike Amplitude in Rat Dentate Gyrus
Quinlan, M. A. L., Strong, V., Skinner, D. M., Martin, G. M., Harley, C. W., & Walling, S. G. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00067 · Cited by 38
Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus
Pérez-Santos, I., Palomero‐Gallagher, N., Zilles, K., & Cavada, C. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab073 · Cited by 39
The state of somatosensory cortex during neuromodulation
Favero, M., Varghese, G., & Castro‐Alamancos, M. A. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00256.2012 · Cited by 37
Pacemaker currents in mouse locus coeruleus neurons
de Oliveira, R. B., Howlett, M. H. C., Gravina, F. S., Imtiaz, M. S., Callister, R. J., Brichta, A. M., & Helden, D. F. V. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.028 · Cited by 38
A Role for Noradrenergic Transmission in the Actions of Phencyclidine and the Antipsychotic and Antistress Effects of mGlu2/3 Receptor Agonists
Swanson, C. J., & Schoepp, D. D. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.019 · Cited by 37
Visual afferents to norepinephrine-containing neurons in cat locus coeruleus
Watabe, K., Nakai, K., & Kasamatsu, T. (1982) · Experimental Brain Research · doi:10.1007/bf00239573 · Cited by 37
Galanin and Consummatory Behavior: Special Relationship with Dietary Fat, Alcohol and Circulating Lipids
Barson, J. R., Morganstern, I., & LEIBOWITZ, S. F. (2010) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0346-0228-0_8 · Cited by 36
Pupil dilation during recognition memory: Isolating unexpected recognition from judgment uncertainty
Mill, R. D., O’Connor, A. R., & Dobbins, I. G. (2016) · Cognition · doi:10.1016/j.cognition.2016.05.018 · Cited by 35
The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson’s disease
Alosaimi, F., Boonstra, J. T., Tan, S. K. H., Temel, Y., & Jahanshahi, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.998932 · Cited by 37
Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus
Caramia, M., Romanov, R. A., Sideromenos, S., Hevesi, Z., Zhao, M., Krasniakova, M., Xu, Q., Harkany, T., & Hökfelt, T. G. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2222095120 · Cited by 35
Caffeine: Implications for Alertness in Athletes
Rogers, N. L., & Dinges, D. F. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.012 · Cited by 35
Dopamine depletion attenuates amphetamine-induced increases of cortical acetylcholine release
Day, J. C., Tham, C., & Fibiger, H. C. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90724-2 · Cited by 36
Noradrenergic neuromodulation in ageing and disease
Krohn, F., Lancini, E., Ludwig, M., Leiman, M., Guruprasath, G., Haag, L., Panczyszyn, J., Düzel, E., Hämmerer, D., & Betts, M. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105311 · Cited by 41
A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking
Matschke, L. A., Bertoune, M., Roeper, J., Snutch, T. P., Oertel, W. H., Rinné, S., & Decher, N. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.08.012 · Cited by 35
Consequences of tuning network function by tonic and phasic locus coeruleus output and stress: Regulating detection and discrimination of peripheral stimuli
Devilbiss, D. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.06.015 · Cited by 33
Sleep-wake and Other Biological Rhythms: Functional Neuroanatomy
Stiller, J. W., & Postolache, T. T. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.008 · Cited by 35
Collateralization of brainstem pathways in the spinal ventral horn in rat as demonstrated with the retrograde fluorescent double-labeling technique
HUISMAN, A. M., Ververs, B., Cavada, C., & Kuypers, H. G. J. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90847-3 · Cited by 35
CRH Effects on Central Noradrenergic Neurons: Relationship to Stress
Valentino, R. J. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_5 · Cited by 35
A metabolite of buspirone increases locus coeruleus activity via alpha2-receptor blockade
Engberg, G. (1989) · Journal of Neural Transmission · doi:10.1007/bf01578749 · Cited by 35
The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer’s Disease
Mercan, D., & Heneka, M. T. (2022) · Biology · doi:10.3390/biology11121822 · Cited by 34
Alteration of Locus coeruleus Neuronal Activity by Interleukin-1 and the Involvement of Endogenous Corticotropin-Releasing Hormone
Borsody, M. K., & Weiss, J. M. (2002) · NeuroImmunoModulation · doi:10.1159/000065186 · Cited by 37
Is Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?
Kapur, A. (2020) · CNS Drugs · doi:10.1007/s40263-020-00758-w · Cited by 36
β-adrenergic modulation of oddball responses in humans
Strange, B. A., & Dolan, R. J. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-29 · Cited by 33
The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats
Hormigo, S., Horta‐Júnior, J. D. A. C., Gómez‐Nieto, R., & López, D. E. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00041 · Cited by 33
Deficits of the automatic orienting of attention in schizophrenic patients
Mario Liotti, A., Dazzi, S., & Umiltà, C. A. (1993) · Journal of Psychiatric Research · doi:10.1016/0022-3956(93)90056-8 · Cited by 33
The beneficial effects of meditation: contribution of the anterior cingulate and locus coeruleus.
Craigmyle, N. A. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00731 · Cited by 32
The Locus Coeruleus: Anatomy, Physiology, and Stress‐Related Neuropsychiatric Disorders
Reyes, B. A. S. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70111 · Cited by 39
Cellular and subcellular localization of alpha-1 adrenoceptors in the rat visual cortex
Nakadate, K., Imamura, K., & Watanabe, Y. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.031 · Cited by 32
Developmental Emergence of Power-Law Wake Behavior Depends Upon the Functional Integrity of the Locus Coeruleus
Gall, A. J., Joshi, B., Best, J. A., Florang, V. R., Doorn, J. A., & BLUMBERG, M. S. (2009) · SLEEP · doi:10.1093/sleep/32.7.920 · Cited by 32
Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?
Kjærby, C., Rasmussen, R. N., Andersen, M., & Nedergaard, M. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2195-y · Cited by 34
Hippocampal norepinephrine-like voltammetric responses following infusion of corticotropin-releasing factor into the locus coeruleus
Palamarchouk, V. S., Zhang, J., Zhou, G., Swiergiel, A. H., & Dunn, A. J. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00241-5 · Cited by 32
Aminergic neurons: State control and plasticity in three model systems
Flicker, C., McCarley, R. W., & Hobson, J. A. (1981) · Cellular and Molecular Neurobiology · doi:10.1007/bf00710716 · Cited by 32
Locus coeruleus involvement in the effects of immobilization stress on the P13 midlatency auditory evoked potential in the rat
Miyazato, H., Skinner, R. D., & García‐Rill, E. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00127-5 · Cited by 32
Evidence for an interaction of opioid and noradrenergic locus coeruleus systems in the regulation of environmental stimulus-directed behavior
Arnsten, A. F. T., Segal, D. L., Loughlin, S. E., & Roberts, D. C. S. (1981) · Brain Research · doi:10.1016/0006-8993(81)91038-6 · Cited by 32
Physiological and Behavioral Analysis of Raphe Unit Activity
Jacobs, B. L., Heym, J. H., & Steinfels, G. F. (1984) · Springer eBooks · doi:10.1007/978-1-4615-7178-0_6 · Cited by 32
Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization?
Guedj, C., David Meunier, A., Meunier, M., & Hadj‐Bouziane, F. (2017) · Neural Plasticity · doi:10.1155/2017/4328015 · Cited by 29
Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats
Ghosh, A., Massaeli, F., Power, K. D., Omoluabi, T., Torraville, S. E., Pritchett, J. B., Sepahvand, T., Strong, V., Reinhardt, C., Chen, X., et al. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab026 · Cited by 29
Validation of a right hemisphere vigilance system as measured by principal component and factor analyzed quantitative electroencephalogram
Arruda, J. E. (1999) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(99)00006-9 · Cited by 31
Simplified dynamics in a model of noradrenergic modulation of cognitive performance
Gilzenrat, M. S., Holmes, B. D., Rajkowski, J., Aston‐Jones, G., & Cohen, J. D. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00055-2 · Cited by 31
Self-citation
Effects of adrenergic drugs on raphe unit activity in freely moving cats
Heym, J. H., Trulson, M. E., & Jacobs, B. L. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90521-5 · Cited by 31
In vivo noradrenaline release evoked in the anteroventral thalamic nucleus by locus coeruleus activation: An electrochemical study
Brun, P., Suaud‐Chagny, M., Gonon, F., & Buda, M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90543-o · Cited by 31
Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models
Coronel‐Oliveros, C., Cofré, R., & Orio, P. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008737 · Cited by 29
The morphological and neurochemical effects of diffuse brain injury on rat central noradrenergic system
Fujinaka, T., Kohmura, E., Yuguchi, T., & Yoshimine, T. (2003) · Neurological Research · doi:10.1179/016164103101201094 · Cited by 30
Habituation and laterality of orienting processes as reflected by slow negative waves
Zimmer, H., & Demmel, R. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00048-x · Cited by 29
Modulation of Prefrontal Cortex Slow Oscillations by Phasic Activation of the Locus Coeruleus
Durán, E., Yang, M., Neves, R. M., Logothetis, N. K., & Eschenko, O. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.028 · Cited by 28
Noradrenergic contributions to cue-driven risk-taking and impulsivity
Chernoff, C. S., Hynes, T. J., & Winstanley, C. A. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05806-x · Cited by 32
Glutamate‐induced post‐activation inhibition of locus coeruleus neurons is mediated by AMPA/kainate receptors and sodium‐dependent potassium currents
Zamalloa, T., Bailey, C. P., & Pineda, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00004.x · Cited by 29
Intracerebroventricular infusion of CRF increases extracellular concentrations of norepinephrine in the hippocampus and cortex as determined by in vivo voltammetry
Zhang, J., Swiergiel, A. H., Palamarchouk, V. S., & Dunn, A. J. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00117-8 · Cited by 29
Locus coeruleus neurons show reduced alpha2-receptor responsiveness and decreased basal activity in spontaneously hypertensive rats
Engberg, G., Oreland, L., Thor�n, P., & Svensson, T. H. (1987) · Journal of Neural Transmission · doi:10.1007/bf01244098 · Cited by 29
Locus Coeruleus as a Target for Psychogeriatric Agents
Olpe, H.-R., Steinmann, M., & Jones, R. S. G. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37603.x · Cited by 29
The Locus Coeruleus—Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review
Caestecker, S., Lescrauwaet, E., Boon, P., Carrette, E., Raedt, R., & Vonck, K. E. J. (2025) · European Journal of Neurology · doi:10.1111/ene.70337 · Cited by 34
Prognostic and Symptomatic Aspects of Rapid Eye Movement Sleep in a Mouse Model of Posttraumatic Stress Disorder
Polta, S., Fenzl, T., Jakubcakova, V., Kimura, M., Yassouridis, A., & Wotjak, C. T. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00060 · Cited by 31
The hippocampus as a possible site of action for increased locomotion during intracerebral infusions of norepinephrine
Flicker, C., & Geyer, M. A. (1982) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(82)91843-x · Cited by 28
Convergent Mechanisms Mediate Preparatory States and Repetition Priming in the Feeding Network ofAplysia
Proekt, A., & Weiss, K. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04029.2003 · Cited by 28
Effects of Methylphenidate on the Membrane Potential and Current in Neurons of the Rat Locus Coeruleus
Ishimatsu, M., Kidani, Y., Tsuda, A., & Akasu, T. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00463.2001 · Cited by 28
Why Does Rem Sleep Occur? A Wake-Up Hypothesis1
Klemm, W. R. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00073 · Cited by 27
Sleep and Dreaming
Siclari, F., & Tononi, G. (2016) · The Neurology of Conciousness · doi:10.1016/b978-0-12-800948-2.00007-8 · Cited by 27
Brainstem fMRI signaling of surprise across different types of deviant stimuli
Mazancieux, A., Mauconduit, F., Amadon, A., de Gee, J. W., Donner, T. H., & Meyniel, F. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113405 · Cited by 29
How Does Light Regulate Mood and Behavioral State?
Milosavljevic, N. (2019) · Clocks & Sleep · doi:10.3390/clockssleep1030027 · Cited by 32
Central noradrenergic depletion by DSP-4 prevents stress-induced memory impairments in the object recognition task
直, 松., 稔朗, 椋., 明人, 阪., Marsden, C. A., & 雅代, 河. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.046 · Cited by 27
The Reticular-Activating Hypofrontality (RAH) Model of Acute Exercise
Audiffren, M. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800778-5.00007-4 · Cited by 31
Valproate enhances GABA-A mediated inhibition of locus coeruleus neurones in vitro
Olpe, H.-R., Steinmann, M., Pozza, M. F., Brugger, F., & Schmutz, M. (1988) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00165630 · Cited by 27
Developmental enhancement of α2-adrenoceptor-mediated suppression of inhibitory synaptic transmission onto mouse cerebellar Purkinje cells
Hirono, M., Matsunaga, W., Chimura, T., & Obata, K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.018 · Cited by 27
Neurobiology of REM sleep
McCarley, R. W. (2010) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52006-7.00010-1 · Cited by 27

Authors: Foote, S. L., Aston-Jones, G., & Bloom, F. E.
Affiliations: Salk Institute for Biological Studies (US)
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1980-05
Volume: 77
Issue: 5
Pages: 3033-3037
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.77.5.3033
PMC: PMC349541
OpenAlex: W2016014417
Cited by: 857
References: 22
Citations by year: 2026: 16 · 2025: 13 · 2024: 18 · 2023: 29 · 2022: 28 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 22 · 2013: 19 · 2012: 25
FWCI: 4.34
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, noradrenergic neurons, neuronal firing rate, sensory stimulation, arousal, auditory stimuli, visual stimuli, somatosensory stimuli, food reward, rats, squirrel monkey
MeSH terms: Action Potentials, Adrenergic Fibers, Animals, Haplorhini, Arousal, Auditory Perception, Evoked Potentials, Locus Coeruleus, Male, Nociceptors, Norepinephrine, Sleep, Visual Perception, Wakefulness, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks