Cited by 857Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness ResearchNeuroscience of respiration and sleep

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

Open access

Foote, S L, Aston-Jones, G, Bloom, F E·1980·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.77.5.3033PMC PMC349541

Open this paper in CoChat — free account

Abstract

By means of extracellular recordings, individual norepinephrine-containing neurons in the locus coeruleus of unanesthetized behaviorally responsive rats and squirrel monkeys were found to respond to specific sensory and behavioral conditions. In rats, distinct clusters of action potentials followed the presentation of various nonnoxious auditory, visual, or somatosensory stimuli at latencies of 15-60 msec. Increased discharge rates were also seen during periods of spontaneous electroencephalogram arousal in both species. In monkeys, these cells responded most vigorously to complex arousing stimuli such as a preferred food. Because the noradrenergic innervation of most forebrain regions arises from the locus coeruleus, these results allow prediction of situations under which this massive projection system would be active and suggest a physiological role for this chemically identified network in specific behavioral processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.77.5.3033

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Applied Nonparametric Statistics
Wozniak, P. J., & Daniel, W. W. (1991) · Technometrics · doi:10.2307/1268795 · Cited by 5,008
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238
Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.
Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety
Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662
The locus coeruleus: A cytoarchitectonic, golgi and immunohistochemical study in the albino rat
Swanson, L. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90207-9 · Cited by 518
The locus coeruleus: neurobiology of a central noradrenergic nucleus
Amaral, D. G., & Sinnamon, H. M. (1977) · Progress in Neurobiology · doi:10.1016/0301-0082(77)90016-8 · Cited by 497
Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex
Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458
Self-citation
Noradrenergic neurons: Morphine inhibition of spontaneous activity
Korf, J., Bunney, B. S., & Aghajanian, G. K. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90045-4 · Cited by 432
Neuronal activity during the sleep-waking cycle
Steriade, M., & Hobson, J. A. (1976) · Progress in Neurobiology · doi:10.1016/0301-0082(76)90013-7 · Cited by 386
Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
Cedarbaum, J. M., & Aghajanian, G. K. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90398-3 · Cited by 382

Show all 22 references

Research works printed but not linked: 3

[19]Foote, S. & Bloom, F. (1979) in Catecholamines: Basic and Clinical Frontiers, eds. Usdin, E., Kopin, I. & Barchas, J. (Pergamon, Elmsford, NY), pp. 625–627.
[20]Jones, G., Segal, M., Foote, S. & Bloom, F. (1979) in Catecholamines: Basic and Clinical Frontiers, eds. Usdin, E., Kopin, I. & Barchas, J. (Pergamon, Elmsford, NY), pp. 643–645.
[21]Siegel, S. (1956) Nonparametric Statistics (McGraw-Hill, New York).

Sorted by citations

Items 501–600 of 851

CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?
Petrakis, I. L., Trevisan, L. A., D’Souza, C., Gil, R. B., Krasnicki, S., Webb, E., Heninger, G. R., Cooney, N. L., & Krystal, J. H. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04355.x · Cited by 27
Serotonin and the Action of LSD in the Brain
Aghajanian, G. K. (1994) · Psychiatric Annals · doi:10.3928/0048-5713-19940301-09 · Cited by 27
Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling
Renden, R., Institóris, Á., Sharma, K., & Tran, C. H. T. (2024) · Communications Biology · doi:10.1038/s42003-024-05996-y · Cited by 30
Experience-Dependent Plasticity and Auditory Cortex
Shepard, K. N., Kilgard, M. P., & Liu, R. C. (2012) · Springer handbook of auditory research · doi:10.1007/978-1-4614-2350-8_10 · Cited by 26
Amphetamine-induced activation of forebrain EEG is prevented by noradrenergic β-receptor blockade in the halothane-anesthetized rat
Berridge, C. W., & Morris, M. F. (2000) · Psychopharmacology · doi:10.1007/s002130050055 · Cited by 26
Modulation of K+ Channels in Hippocampal Neurons: Transmitters Acting via Cyclic AMP Enhance the Excitability of Hippocampal Neurons Through Kinase-Dependent and -Independent Modulation of AHP- and h-Channels
Storm, J. F., Pedarzani, P., Haug, T. M., & Winther, T. (2000) · Springer eBooks · doi:10.1007/978-4-431-66973-9_11 · Cited by 25
Temporal dynamics of arousal and attention in 12‐month‐old infants
Wass, S. V., Clackson, K., & de Barbaro, K. (2016) · Developmental Psychobiology · doi:10.1002/dev.21406 · Cited by 25
Noradrenergic correlates of chronic cocaine craving: neuromelanin and functional brain imaging
Wang, W., Zhornitsky, S., Zhang, S., & Li, C. R. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00937-9 · Cited by 26
Electrophysiological correlates of attention in the locus coeruleus–prelimbic cortex circuit during the rodent continuous performance test
Hallock, H. L., Adiraju, S. S., Miranda-Barrientos, J. A., McInerney, J. M., Oh, S., DeBrosse, A. C., Li, Y., Carr, G. V., & Martinowich, K. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01692-3 · Cited by 23
Distinct behavioral and neurochemical alterations induced by intermittent hypoxia or paradoxical sleep deprivation in rats
Perry, J. C., D’Almeida, V., Ishikura, I. A., & Tufik, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.017 · Cited by 25
Locus coeruleus electrophysiological activity and responsivity to corticotropin-releasing factor in inbred hypertensive and normotensive rats
Conti, L. H., Youngblood, K. L., Printz, M. P., & Foote, S. L. (1997) · Brain Research · doi:10.1016/s0006-8993(97)81683-6 · Cited by 25
Self-citation
Ultradian periodicities in EEG and behavior in the squirrel monkey (Saimiri sciureus)
Ehlers, C. L., & Foote, S. L. (1984) · American Journal of Primatology · doi:10.1002/ajp.1350070407 · Cited by 25
Self-citation
Some in vivo electrophysiological properties of locus coeruleus neurones in fetal rats
Sakaguchi, T., & Nakamura, S. (1987) · Experimental Brain Research · doi:10.1007/bf00255239 · Cited by 25
Attention-deficit/hyperactivity disorder: neurophysiology, information processing, arousal and drug development
ROWE, D. L., & Hermens, D. F. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.11.1721 · Cited by 25
Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy
Fureman, B. E., & Hess, E. J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.004 · Cited by 24
Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease
Daulatzai, M. A. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9643-3 · Cited by 27
Evaluation of Neurotransmitter Alterations in Four Distinct Brain Regions After Rapid Eye Movement Sleep Deprivation (REMSD) Induced Mania-Like Behaviour in Swiss Albino Mice
Siddique, S. A., Tamilselvan, T., Vishnupriya, M., & Balamurugan, E. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2533-8 · Cited by 24
Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory
Davies, M. F., Tsui, J. Y., Flannery, J. A., Li, X., DeLorey, T. M., & Hoffman, B. B. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03248-7 · Cited by 23
Electrophysiological perspectives on locus coeruleus: Its role in cognitive versus vegetative functions
Olpe, H.-R., Steinmann, M., & Jones, R. S. G. (1985) · Physiological Psychology · doi:10.3758/bf03326518 · Cited by 24
Lateral septum modulates cortical state to tune responsivity to threat stimuli
Hashimoto, M., Brito, S. I., Venner, A., Pasqualini, A. L., Yang, T. L., Allen, D. F., Stankowicz, S. J., Fuller, P. M., & Anthony, T. E. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111521 · Cited by 23
The 5–12 Hz oscillations in the barrel cortex of awake rats – Sustained attention during behavioral idling?
Sobolewski, A., Świejkowski, D. A., Wróbel, A., & Kublik, E. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.08.006 · Cited by 23
The Orexin/Hypocretin System
Nishino, S., & Sakurai, T. (2005) · Contemporary clinical neuroscience · doi:10.1385/1592599508 · Cited by 64
Inhibitory Control and Drug Abuse Prevention
Bardo, M. T., Fishbein, D. H., & Milich, R. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1268-8 · Cited by 66
Importance of hypothalamic function to stressor-induced responsiveness of the GABAA receptor in the cerebral cortex: a non-corticosterone influence
Kellogg, C. K., Inglefield, J. R., Taylor, M. K., & Pleger, G. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90879-r · Cited by 23
A procedure for using proton magnetic resonance imaging to determine stereotaxic coordinates of the monkey's brain
Rebert, C. S., Hurd, R. E., Matteucci, M. J., DeLaPaz, R. L., & Enzmann, D. R. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90076-c · Cited by 23
Neuropeptide S
Koob, G. F., & Greenwell, T. N. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.007 · Cited by 23
Putative Receptors Underpinning l-Lactate Signalling in Locus Coeruleus
Mosienko, V., Rasooli-Nejad, S. M. A., Kishi, K., Both, M. D. D., Jane, D. E., Huentelman, M. J., Kasparov, S., & Teschemacher, A. G. (2018) · Neuroglia · doi:10.3390/neuroglia1020025 · Cited by 24
Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus
Wilmot, J. H., Diniz, C. R. A. F., Crestani, A. P., Puhger, K. R., Roshgadol, J., Tian, L., & Wiltgen, B. J. (2023) · eLife · doi:10.7554/elife.91465 · Cited by 38
The behavioural response of mice lacking NK1 receptors to guanfacine resembles its clinical profile in treatment of ADHD
Pillidge, K., Porter, A. J., Dudley, J., Tsai, Y., Heal, D. J., & Stanford, S. C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12860 · Cited by 23
The effects of α2-adrenoceptor stimulation on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats
Riekkinen, P. J., Lammintausta, R. A. S., Ekonsalo, T., & Sirviö, J. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90856-d · Cited by 22
Desipramine potentiation of the acute depressant effects of ethanol: Modulation by α2-adrenoreceptors and stress
Boyce‐Rustay, J. M., Palachick, B., Hefner, K. R., Chen, Y.-C., Karlsson, R., Millstein, R. A., Harvey-White, J. D., & Holmes, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.032 · Cited by 22
IRE1α pathway of endoplasmic reticulum stress induces neuronal apoptosis in the locus coeruleus of rats under single prolonged stress
Zhao, W., Han, F., & Shi, Y. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.008 · Cited by 22
Noradrenergic But Not Dopaminergic Neurons Signal Task State Changes and Predict Reengagement After a Failure
Jahn, C. I., Varazzani, C., Sallet, J., Walton, M. E., & Bouret, S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa089 · Cited by 24
Contrasting effects of noradrenergic β-receptor blockade within the medial septal area on forebrain electroencephalographic and behavioral activity state in anesthetized and unanesthetized rat
Berridge, C. W., & Wifler, K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00047-6 · Cited by 22
Paroxetine-Induced Increase in Activity of Locus Coeruleus Neurons in Adolescent Rats: Implication of a Countertherapeutic Effect of an Antidepressant
West, C. H. K., Ritchie, J., & Weiss, J. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.34 · Cited by 22
Developmental auditory exposure shapes responses of catecholaminergic neurons to socially-modulated song
Barr, H. J., & Woolley, S. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30039-y · Cited by 24
Corticotropin-Releasing Factor
Valentino, R. J., & Bockstaele, E. V. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50064-0 · Cited by 22
Differential effects of forskolin on tyrosine hydroxylase gene transcription in identified brainstem catecholaminergic neuronal subtypes in organotypic culture
Rusnák, M., & Gainer, H. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03913.x · Cited by 22
Increased firing of locus coeruleus neurons associated with preparatory set in rats
Yamamoto, K.-I., & Ozawa, N. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90211-5 · Cited by 22
Locus coeruleus-induced modulation of forebrain electroencephalographic (EEG) state in halothane-anesthetized rat
Berridge, C. W., & Foote, S. L. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90174-0 · Cited by 22
Self-citation
Single Unit Activity of Brain Monoamine‐Containing Neurons in Freely Moving Animalsa
Jacobs, B. L. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb23604.x · Cited by 22
Computational modeling suggests distinct, location-specific function of norepinephrine in olfactory bulb and piriform cortex
de Almeida, L., Reiner, S. J., Ennis, M. J., & Linster, C. (2015) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2015.00073 · Cited by 21
Chronic Alterations in Monoaminergic Cells in the Locus Coeruleus in Orexin Neuron-Ablated Narcoleptic Mice
Tsujino, N., Tsunematsu, T., Uchigashima, M., Konno, K., Yamanaka, A., Kobayashi, K., Watanabe, M., Koyama, Y., & Sakurai, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070012 · Cited by 22
Stress Response, Brain Noradrenergic System and Cognition
Winklewski, P. J., Radkowski, M., Wszędybył-Winklewska, M., & Demkow, U. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_204 · Cited by 23
An ?2-adrenergic mode of action of chlordimeform on rat visual function*1
Boyes, W. K. (1988) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(88)90180-9 · Cited by 21
Norepinephrine
Rogawski, M. A. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4961-7_8 · Cited by 21
Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state
Gray, S. R., Ye, L., Ye, J. Y., & Paukert, M. (2021) · Science Advances · doi:10.1126/sciadv.abk1378 · Cited by 24
Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice
Li, S., Franken, P., & Vassalli, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-33069-8 · Cited by 18
Why is there an increased risk for sudden infant death in prone sleeping? Fear paralysis and atrial stretch reflexes implicated?
Kaada, B. R. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13079.x · Cited by 20
The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticityPreprint
Jordan, R., & Keller, G. B. (2023) · eLife · doi:10.7554/elife.85111.1 · Cited by 21
The role of the LC-NE system in attention: From cells, to systems, to sensory-motor control
Torres, A. S., Robison, M. K., & Brewer, G. A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106233 · Cited by 19
Control of sleep-to-wake transitions via fast amino acid and slow neuropeptide transmission
Mosqueiro, T. S., de Lecea, L., & Huerta, R. (2014) · New Journal of Physics · doi:10.1088/1367-2630/16/11/115010 · Cited by 19
Physiological properties of ascending locus coeruleus axons in the squirrel monkey
Segal, M., Foote, S. L., & Aston‐Jones, G. (1983) · Brain Research · doi:10.1016/0006-8993(83)90723-0 · Cited by 19
Self-citation
Catecholamine Metabolism in Locus Coeruleus Neurons: A Study of its Activation by Sciatic Nerve Stimulation in the Rat
Brun, P., Suaud‐Chagny, M., Lachuer, J., Gonon, F., & Buda, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00827.x · Cited by 19
Attention and the Brain
Picton, T. W., Stuss, D. T., & Marshall, K. C. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-268330-5.50008-1 · Cited by 19
Developmental disorders affecting the respiratory system: CCHS and ROHHAD
Ceccherini, I., Kurek, K. C., & Weese‐Mayer, D. E. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-323-91532-8.00005-7 · Cited by 18
The Locus Coeruleus: Where Cognitive and Emotional Processing Meet the Eye
Huang, R., & Clewett, D. (2024) · Springer eBooks · doi:10.1007/978-3-031-54896-3_1 · Cited by 23
Repeated Social Stress Increases Reward Salience and Impairs Encoding of Prediction by Rat Locus Coeruleus Neurons
Chaijale, N., Snyder, K., Arner, J., Curtis, A. L., & Valentino, R. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.200 · Cited by 19
Heterogeneous organization and function of the central noradrenergic system
Waterhouse, B. D., & Chandler, D. J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.050 · Cited by 22
Morphological correlates of sex differences in acoustic startle response and prepulse inhibition through projections from locus coeruleus to cochlear root neurons
Hormigo, S., Gómez‐Nieto, R., Sancho, C., Herrero-Turrión, M. J., Carro, J., López, D. E., & Horta‐Júnior, J. D. A. C. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1415-1 · Cited by 18
Flumazenil but not FG7142 reverses the decrease in pentobarbital sleep caused by activation of central noradrenergic systems in mice
Matsumoto, K., Kohno, S.-I., Ojima, K., & Watanabe, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00176-5 · Cited by 18
Clonidine and cortical plasticity: Possible evidence for noradrenergic involvement
Nelson, S. B., Schwartz, M. A., & Daniels, J. D. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90005-7 · Cited by 18
Neurons in rostral ventrolateral medulla mediate vestibular inhibition of locus coeruleus in rats
Nishiike, S., Takeda, N., Kubo, T., & Nakamura, S. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00436-8 · Cited by 18
Study of Brain Noradrenergic Neurons by Use of In Vivo Voltammetry
Buda, M., & Gonon, F. (1987) · Humana Press eBooks · doi:10.1007/978-1-59259-463-4_7 · Cited by 18
Norepinephrine Deficiency and Behavioral Senescence in Aged Rats
Collier, T. J., Gash, D. M., & Sladek, J. R. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23689.x · Cited by 18
Frequency–dependency of the involvement of dopamine D1 / D5 and beta‐adrenergic receptors in hippocampal LTD triggered by locus coeruleus stimulation
Babushkina, N., & Manahan‐Vaughan, D. (2022) · Hippocampus · doi:10.1002/hipo.23419 · Cited by 18
Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus
Wilmot, J. H., Diniz, C. R. A. F., Crestani, A. P., Puhger, K. R., Roshgadol, J., Tian, L., & Wiltgen, B. J. (2024) · eLife · doi:10.7554/elife.91465.3 · Cited by 17
Effects of DSP4 and methylphenidate on spatial memory performance in rats
Sontag, T. A., Hauser, J., Tucha, O. M., & Lange, K. W. (2011) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-011-0067-x · Cited by 17
Neuronal Activation in the Periaqueductal Gray Matter Upon Electrical Stimulation of the Bladder
Mériaux, C., Hohnen, R., Schipper, S., Zare, A., Jahanshahi, A., Birder, L. A., Temel, Y., & van Koeveringe, G. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00133 · Cited by 17
Review—In Vivo Electrochemical Measurements of Norepinephrine in the Brain: Current Status and Remaining Challenges
Park, J., Bhimani, R. V., & Bass, C. E. (2018) · Journal of The Electrochemical Society · doi:10.1149/2.0091812jes · Cited by 17
Carbachol-induced increases in locus coeruleus spontaneous activity are associated with an altered pattern of response to sensory stimuli
Valentino, R. J., & Aulisi, E. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90313-2 · Cited by 17
Facilitation of learning consecutive to electrical stimulation of the locus coeruleus: cognitive alteration or stress-reduction?
Velley, L., Cardo, B., Kempf, E., Mormède, P., Nassif, S., & Velly, J. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63834-0 · Cited by 17
Role of Corticotropin-Releasing Factor in Mediating the Expression of Defensive Behavior
Takahashi, L. K., & Kalin, N. H. (1989) · Springer eBooks · doi:10.1007/978-94-009-2403-1_39 · Cited by 17
Sensory stimuli differentially affect in vivo nigral and striatal [3H]serotonin release in the cat
Reisine, T., Soubrié, P., Artaud, F., & Glowinski, J. (1982) · Brain Research · doi:10.1016/0006-8993(82)90611-4 · Cited by 17
Electrophysiology of the Locus Coeruleus: Implications for Stress-Induced Depression
Weiss, J. M., & Simson, P. E. (1989) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6762-8_7 · Cited by 17
Diverse ancestral brainstem noradrenergic neuron activity across species and biological factorsPreprint
Kelberman, M. A., Rodberg, E. M., Munn, B. R., Arabzadeh, E., Bair-Marshall, C. J., Berridge, C. W., Berrocoso, E., Breton‐Provencher, V., Chandler, D. J., Che, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.14.618224 · Cited by 23
Sleep and dreaming
Tononi, G. (2009) · The Neurology of Consciousness · doi:10.1016/b978-0-12-374168-4.00008-3 · Cited by 16
Toward a computational role for locus coeruleus/norepinephrine arousal systems
Nassar, M. R. (2024) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2024.101407 · Cited by 18
Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons
Jaremko, K. M., Thompson, N. L., Reyes, B. A. S., Jin, J., Ebersole, B., Jenney, C. B., Grigson, P. S., Levenson, R. G., Berrettini, W. H., & Bockstaele, E. J. V. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.003 · Cited by 16
EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
Johnston, R., Snyder, A. C., Schibler, R. S., & Smith, M. A. (2022) · eNeuro · doi:10.1523/eneuro.0012-22.2022 · Cited by 20
Spinal cord injury immediately decreases anesthetic requirements in rats
Foffani, G., Humanes-Valera, D., Muñoz, F. C., Oliviero, A., & Aguilar, J. (2011) · Spinal Cord · doi:10.1038/sc.2011.11 · Cited by 16
Novel objects in a holeboard probe the role of the locus coerulus in curiosity: Support for two modes of attention in the rat.
Mansour, A. A. H., Babstock, D. M., Penney, J. H., Martin, G. M., McLean, J. H., & Harley, C. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.3.621 · Cited by 16
Recent Evidence of Memory Processing in Sleep
Pavlides, C., & Ribeiro, S. T. G. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198574002.003.0017 · Cited by 16
Brain Noradrenergic Neurons, Corticotropin-Releasing Factor, and Stress
Valentino, R. J., & Foote, S. L. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5152-8_9 · Cited by 16
Self-citation
Integrative Biological, Cognitive and Affective Modeling of a Drug-Therapy for a Post-traumatic Stress Disorder
Ziabari, S. S. M., & Jan Treur, A. (2018) · Lecture notes in computer science · doi:10.1007/978-3-030-04070-3_23 · Cited by 15
Age-related changes in the functional integrity of the phasic alerting system: a pupillometric investigation
He, M., Heindel, W. C., Nassar, M. R., Siefert, E. M., & Festa, E. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.025 · Cited by 16
Cocaine effects on brain noradrenergic neurons of anesthetized and unanesthetized rats
Curtis, A. L., Conti, E., & Valentino, R. J. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90165-y · Cited by 15
The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
Manza, P., Hu, S., Ide, J. S., Farr, O. M., Zhang, S., Leung, H., & Li, C. R. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881115625102 · Cited by 16
Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort
Kelly, S. C., Nelson, P. T., & Counts, S. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab017 · Cited by 15
Wake-Promoting Actions of Medial Basal Forebrain β₂ Receptor Stimulation.
Berridge, C. W., Stellick, R. L., & Schmeichel, B. E. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.3.743 · Cited by 15
Mechanism of noradrenaline-induced stimulation of Na–K ATPase activity in the rat brain: implications on REM sleep deprivation-induced increase in brain excitability
Mallick, B. N., Singh, S., & Singh, A. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0260-9 · Cited by 15
Nifedipine, an L-type Calcium Channel Blocker, Restores the Hypnotic Response in Rats Made Tolerant to the Alpha-2 Adrenergic Agonist Dexmedetomidine
Reid, K., Guo, T., Davies, M. F., & Maze, M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37118-6 · Cited by 15
The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post-Traumatic Stress Disorder
Berridge, C. W. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-329-9_10 · Cited by 15
Functional influence of the central noradrenergic system on the skin conductance activity in rats
Yamamoto, K.-I., Ozawa, N., Shinba, T., & Hoshino, T. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90095-7 · Cited by 15
The central noradrenergic system: an overview
Viljoen, M., & Panzer, A. (2007) · African Journal of Psychiatry · doi:10.4314/ajpsy.v10i3.30245 · Cited by 15
Peripheral, but not local or intracerebroventricular, administration of benzodiazepines attenuates evoked activity of locus coeruleus neurons
Simson, P. E., & Weiss, J. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)90241-2 · Cited by 15
Persistent α1-adrenergic receptor function in the nucleus locus coeruleus causes hyperexcitability in AD/HD model rats
Igata, S., Hayashi, T., Itoh, M., Akasu, T., Takano, M., & Ishimatsu, M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01103.2012 · Cited by 14
Role of central serotonin and noradrenaline interactions in the antidepressants’ action: Electrophysiological and neurochemical evidence
Delcourte, S., Etiévant, A., & Haddjeri, N. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.002 · Cited by 17
Phasic activation of the locus coeruleus attenuates the acoustic startle response by increasing cortical arousal
Yang, M., Logothetis, N. K., & Eschenko, O. (2021) · Scientific Reports · doi:10.1038/s41598-020-80703-5 · Cited by 14
Functional interactions between stress neuromediators and the locus coeruleus–norepinephrine system
Valentino, R. J., & Bockstaele, E. J. V. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80026-4 · Cited by 14

Authors: Foote, S. L., Aston-Jones, G., & Bloom, F. E.
Affiliations: Salk Institute for Biological Studies (US)
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1980-05
Volume: 77
Issue: 5
Pages: 3033-3037
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.77.5.3033
PMC: PMC349541
OpenAlex: W2016014417
Cited by: 857
References: 22
Citations by year: 2026: 16 · 2025: 13 · 2024: 18 · 2023: 29 · 2022: 28 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 22 · 2013: 19 · 2012: 25
FWCI: 4.34
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, noradrenergic neurons, neuronal firing rate, sensory stimulation, arousal, auditory stimuli, visual stimuli, somatosensory stimuli, food reward, rats, squirrel monkey
MeSH terms: Action Potentials, Adrenergic Fibers, Animals, Haplorhini, Arousal, Auditory Perception, Evoked Potentials, Locus Coeruleus, Male, Nociceptors, Norepinephrine, Sleep, Visual Perception, Wakefulness, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks