The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.
Open accessAbstract
Multiplication-stimulating activity (MSA), purified from medium conditioned by the BRL-3A rat liver cell line, previously has been shown to be closely related to the human somatomedins or insulin-like growth factors. A radioimmunoassay was utilized to measure MSA levels in sera from fetal, maternal, and young rats. A serum somatomedin-binding protein was found to interfere in the radioimmunoassay by competing with antibody for binding 125I-labeled MSA. Therefore, prior to radioimmunoassay, sera were filtered on Sephadex G-75 in 1 M acetic acid to dissociate and separate somatomedin activity from the binding protein. Concentrations of MSA by radioimmunoassay were 20- to 100-fold higher in feta rat sera (1.8-4.4 micrograms/ml) than in maternal sera. MSA levels gradually decreased after birth, reaching maternal levels by day 25 of extrauterine life. MSA concentrations in feta rat sera also were found to be correspondingly high by a rat liver membrane radioreceptor assay and a competitive binding protein assay using rat serum somatomedin-binding protein. The findings of higher levels of MSA in fetal than in maternal rat sera and the gradual decline in MSA serum concentrations after birth are in direct contrast to total somatomedin activities measured by biosassay. Thus, MSA may function as a growth factor in the fetal rat whereas other somatomedins may play a role in stimulating growth during extrauterine life.
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Cites
Somatomedin: Proposed Designation for Sulphation Factor
DAUGHADAY, W. H., HALL, K., RABEN, M. S., SALMON, W. D., LEO VAN DEN BRANDE, J., & VAN WYK, J. J. (1972) · Nature · doi:10.1038/235107a0 · Cited by 842
Dulak, N. C., & Temin, H. M. (1973) · Journal of Cellular Physiology · doi:10.1002/jcp.1040810204 · Cited by 334
Demonstration of Specific Plasma Protein Binding Sites For Somatomedin
HINTZ, R. L., & LIU, F. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-5-988 · Cited by 270
Binding of nonsuppressible insulinlike activity to human serum
Zapf, J., WALDVOGEL, M., & Froesch, E. R. (1975) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(75)90296-9 · Cited by 255
Dulak, N. C., & Temin, H. M. (1973) · Journal of Cellular Physiology · doi:10.1002/jcp.1040810205 · Cited by 181
Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone
Moses, A. C., Nissley, S. P., COHEN, K. L., & Rechler, M. M. (1976) · Nature · doi:10.1038/263137a0 · Cited by 144
Self-citationSmith, G. L. N., & Temin, H. M. (1974) · Journal of Cellular Physiology · doi:10.1002/jcp.1040840204 · Cited by 120
Cited by
Lund, P. K., Moats-Staats, B. M., Hynes, M. A., Simmons, J. G., Jansen, M., D'Ercole, A. J., & Van Wyk, J. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66903-0 · Cited by 532
Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.
Brown, A. L., Graham, D. E., Nissley, S. P., Hill, D. J., Strain, A. J., & Rechler, M. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69282-8 · Cited by 321
Self-citationVoutilainen, R., & Miller, W. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.6.1590 · Cited by 238
Mesiano, S., Mellon, S. H., & Jaffe, R. B. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473412 · Cited by 135
Metadata
- Authors
- Moses, A. C., Nissley, S. P., Short, P. A., Rechler, M. M., White, R. M., Knight, A. B., & Higa, O. Z.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-06
- Volume
- 77
- Issue
- 6
- Pages
- 3649-3653
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044917338
- Cited by
- 310
- References
- 7
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Moses, A. C., Nissley, S. P., Short, P. A., Rechler, M. M., White, R. M., Knight, A. B., & Higa, O. Z. (1980). Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.6.3649
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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