The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Calmodulin activates prokaryotic adenylate cyclase.
Open accessAbstract
The adenylate cyclase of Bordetella pertussis is stimulated 100- to 1000-fold in a dose-dependent manner by calf brain calmodulin. The system has the following properties. (i) The activation is prevented by ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid and restored by Ca2+. (ii) Oxidation of the methionine residues of calmodulin abolishes the ability to activate the cyclase. (iii) Trifluoperazine inhibits calmodulin-activated cyclase. (iv) A troponin C preparation stimulates the B. pertussis cyclase with < 0.01 the potency of calmodulin. Although calmodulin has not been demonstrated in prokaryotes, this is an example of a (eukaryotic) calmodulin effect in a prokaryote.
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Cites
A highly sensitive adenylate cyclase assay
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Calmodulin Plays a Pivotal Role in Cellular Regulation
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Membrane Stabilization by Drugs: Tranquilizers, Steroids, and Anesthetics
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Calmodulin Activation of Adenylate Cyclase in Pancreatic Islets
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Cited by
Leppla, S. H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.10.3162 · Cited by 935
RTX proteins: a highly diverse family secreted by a common mechanism
Linhartová, I., Bumba, L., Mašín, J., Basler, M., Osička, R., Kamanová, J., Procházková, K., Adkins, I., Hejnová-Holubová, J., Sadílková, L., et al. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00231.x · Cited by 530
Translocation of a hybrid YopE‐adenylate cyclase from Yersinia enterocolitica into HeLa cells
Sory, M., & Cornelis, G. R. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb02191.x · Cited by 532
Bacterial toxins: cellular mechanisms of action
Middlebrook, J. L., & Dorland, R. B. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.3.199-221.1984 · Cited by 357
Guermonprez, P., Khelef, N., Blouin, E., Rieu, P., Ricciardi-Castagnoli, P., Guiso, N., Ladant, D., & Leclerc, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1035 · Cited by 339
Metadata
- Authors
- Wolff, J., Cook, G. H., Goldhammer, A. R., & Berkowitz, S. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-07
- Volume
- 77
- Issue
- 7
- Pages
- 3841-3844
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978952396
- Cited by
- 276
- References
- 16
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wolff, J., Cook, G. H., Goldhammer, A. R., & Berkowitz, S. A. (1980). Calmodulin activates prokaryotic adenylate cyclase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.7.3841
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
