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Characterization of a class of cationic proteins that specifically interact with intermediate filaments.
Open accessAbstract
We describe a class of cationic structural proteins that associate specifically with intermediate filaments (IF) but not with other types of cytoskeletal proteins. These proteins, for which the term filaggrin is introduced, are isolated from the stratum corneum of mammalian epidermis. They are species-distinct proteins; for example, rat and mouse filaggrin have different molecular weights and amino acid compositions, but are nevertheless chemically and functionally ver similar. They interact in vitro with the IF several different types of cells to form large fibers or macrofibrils in which many IF are highly aligned in parallel arrays. Stoichiometric analyses suggest that two molecules of filaggrin bind to each three-chain building block of the IF, possibly by ionic interactions with the coiled-coil alpha-helical regions of the IF.
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Cited by
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Boyce, S. T., & Ham, R. G. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12540422 · Cited by 1,083
Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice
Kawasaki, H., Nagao, K., Kubo, A., Hata, T., Shimizu, A., Mizuno, H., Yamada, T., & Amagai, M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.068 · Cited by 301
Rerknimitr, P., Otsuka, A., Nakashima, C., & Kabashima, K. (2017) · Inflammation and Regeneration · doi:10.1186/s41232-017-0044-7 · Cited by 187
Metadata
- Authors
- Steinert, P. M., Cantieri, J. S., Teller, D. C., Lonsdale-Eccles, J. D., & Dale, B. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-07
- Volume
- 78
- Issue
- 7
- Pages
- 4097-4101
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998464125
- Cited by
- 320
- References
- 0
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Steinert, P. M., Cantieri, J. S., Teller, D. C., Lonsdale-Eccles, J. D., & Dale, B. A. (1981). Characterization of a class of cationic proteins that specifically interact with intermediate filaments. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.7.4097
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
