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Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility.
Open accessAbstract
In immunohistochemical studies using antisera to peptide YY (PYY), a 36 amino acid polypeptide isolated from porcine duodenum, it was found that PYY-like immunoreactivity occurred mainly in endocrine cells of the gastrointestinal mucosa. PYY-immunoreactive cells were particularly abundant in the distal intestine and have been observed in five species, including man. By radioimmunoassay it was found that, in the rat, the amount of PYY immunoreactivity was about 100-fold higher in the colon than in the duodenum. The chromatographic profiles of PYY immunoreactivity from the rat colon and porcine PYY on a SP-Sephadex ion exchanger were similar. Furthermore, serial dilutions of extracts from the rat colon and porcine PYY had parallel displacement curves in radioimmunoassay. Close intraarterial administration of PYY in cats caused an intestinal vasoconstriction and an inhibition of jejunal and colonic motility. Simultaneously there was a rise in systemic arterial blood pressure. These effects of PYY were also observed after pretreatment with adrenergic blocking agents. It is concluded that PYY is a gastrointestinal peptide that is present mainly in endocrine cells of distal intestine and that has effect on both intestinal motility and the cardiovascular system.
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Citations
Cited by
Neuropeptide Y: complete amino acid sequence of the brain peptide.
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5485 · Cited by 1,378
Self-citationLambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
Neuropeptide Y receptors: how to get subtype selectivity
Pedragosa-Badia, X., Stichel, J., & Beck-Sickinger, A. G. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00005 · Cited by 191
The role of PYY in feeding regulation
Ueno, H., Yamaguchi, H., Mizuta, M., & Nakazato, M. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.09.011 · Cited by 105
The role of peptide YY in regulating glucose homeostasis
Boey, D., Sainsbury, A., & Herzog, H. (2007) · Peptides · doi:10.1016/j.peptides.2006.07.031 · Cited by 77
Metadata
- Authors
- Lundberg, J. M., Tatemoto, K., Terenius, L., Hellström, P. M., Mutt, V, Hökfelt, T., & Hamberger, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-07
- Volume
- 79
- Issue
- 14
- Pages
- 4471-4475
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979456394
- Cited by
- 405
- References
- 0
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Lundberg, J. M., Tatemoto, K., Terenius, L., Hellström, P. M., Mutt, V, Hökfelt, T., & Hamberger, B. (1982). Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.14.4471
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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