The role of PYY in feeding regulation

Ueno, Hiroaki; Yamaguchi, Hideki; Mizuta, Masanari; Nakazato, Masamitsu

doi:10.1016/j.regpep.2007.09.011

Cited by 105Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyAdipokines, Inflammation, and Metabolic Diseases

The role of PYY in feeding regulation

Ueno, Hiroaki, Yamaguchi, Hideki, Mizuta, Masanari, Nakazato, Masamitsu·2008·Regulatory Peptides

DOI 10.1016/j.regpep.2007.09.011

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Abstract

Peptide YY (PYY), a 36-amino-acid peptide, is secreted primarily from L-cells residing in the intestinal mucosa of the ileum and large intestine. PYY, which belongs to a family of peptides including neuropeptide Y (NPY) and pancreatic polypeptide, is released into the circulation as PYY(1-36) and PYY(3-36); the latter is the major form of PYY in gut mucosal endocrine cells and throughout the circulation. Plasma PYY levels begin to rise within 15 min after starting to eat and plateau within approximately 90 min, remaining elevated for up to 6 h. Exogenous administration of PYY(3-36) reduces energy intake and body weight in both humans and animals. Via Y2 receptors, the satiety signal mediated by PYY inhibits NPY neurons and activates pro-opiomelanocortin neurons within the hypothalamic arcuate nucleus. Peripheral PYY(3-36) binds Y2 receptors on vagal afferent terminals to transmit the satiety signal to the brain. PYY(3-36) may have therapeutic potential in human obesity.

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These gut peptides can activate their cognate receptors located in vagal afferents to signal to the brainstem.
“Moreover, these gut peptides can activate their cognate receptors located in vagal afferents to signal to the brainstem [179,180].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [180]

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Authors: Ueno, H., Yamaguchi, H., Mizuta, M., & Nakazato, M.
Affiliations: University of Miyazaki (JP)
Corresponding author: Nakazato, Masamitsu
ORCID: Ueno, Hiroaki
Yamaguchi, Hideki
Nakazato, Masamitsu
Venue: Regulatory Peptides
Publisher: Elsevier BV
Published: 2008-01
Volume: 145
Issue: 1-3
Pages: 12-16
ISSN: 0167-0115 (ISSN-L)
DOI: 10.1016/j.regpep.2007.09.011
OpenAlex: W2086380824
Cited by: 105
References: 50
Citations by year: 2026: 7 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 4 · 2012: 9
FWCI: 0.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Regulatory Peptides (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: peptide YY, PYY3-36, food intake regulation, satiety, L cells, neuropeptide Y, Y2 receptor, hypothalamic arcuate nucleus, vagal afferents, energy intake, body weight, obesity treatment, gastrointestinal endocrine cells
MeSH terms: Animals, Feeding Behavior, Humans, Organ Specificity, Receptors, Gastrointestinal Hormone, Peptide YY

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The role of PYY in feeding regulation

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