Cited by 77Regulation of Appetite and ObesityPancreatic function and diabetesDiabetes Treatment and Management

The role of peptide YY in regulating glucose homeostasis

Boey, Dana, Sainsbury, Amanda, Herzog, Herbert·2007·Peptides

Abstract

The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there have been several interesting clinical and animal studies investigating the role of PYY in glucose homeostasis. This review aims to present an updated summary of findings over the last few decades highlighting the role of PYY in regulating insulin output and insulin sensitivity, and the potential mechanisms involved.

Integrity signals

Registry

Crossref · 10.1016/j.peptides.2006.07.031

Cites

53 of 53 references verified0 citation errors · 0 not checkable

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  • Increased GLP-1 and PYY levels together with an absence of a compensatory rise in ghrelin in most RYGB patients would be expected to favor improved insulin sensitivity.

    “Increased GLP-1 and PYY levels together with an absence of a compensatory rise in ghrelin in most RYGB patients would be expected to favor improved insulin sensitivity as these hormone affect glucose homeostasis in addition to appetitive behavior (8, 30–32).”

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Authors
Boey, D., Sainsbury, A., & Herzog, H.
Affiliations
Garvan Institute of Medical Research (AU)
Corresponding author
Boey, Dana
Venue
Peptides
Publisher
Elsevier BV
Published
2007-02
Volume
28
Issue
2
Pages
390-395
ISSN
0196-9781 (ISSN-L)
OpenAlex
W2060154835
Cited by
77
References
54
Citations by year
2026: 4 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 1 · 2013: 4 · 2012: 10
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
  • The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
Funders
National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
peptide YY, glucose homeostasis, insulin secretion, insulin sensitivity, gastrointestinal hormones, satiety, dietary intake, body weight regulation, gastrointestinal function
MeSH terms
Animals, Clinical Trials as Topic, Glucose, Homeostasis, Humans, Insulin Resistance, Peptide YY

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