The role of peptide YY in regulating glucose homeostasis
Abstract
The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there have been several interesting clinical and animal studies investigating the role of PYY in glucose homeostasis. This review aims to present an updated summary of findings over the last few decades highlighting the role of PYY in regulating insulin output and insulin sensitivity, and the potential mechanisms involved.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased GLP-1 and PYY levels together with an absence of a compensatory rise in ghrelin in most RYGB patients would be expected to favor improved insulin sensitivity.
“Increased GLP-1 and PYY levels together with an absence of a compensatory rise in ghrelin in most RYGB patients would be expected to favor improved insulin sensitivity as these hormone affect glucose homeostasis in addition to appetitive behavior (8, 30–32).”
From Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass (2009) · cites this paper as [30]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works
Self-citationInhibition of Food Intake in Obese Subjects by Peptide YY <sub>3–36</sub>
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works
Human distribution and release of a putative new gut hormone, peptide YY
Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064 · see citing works
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2514 · Cited by 615 · see citing works
Y-receptor subtypes—how many more?
Blomqvist, A. G., & Herzog, H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01057-0 · Cited by 533 · see citing works
Self-citationZarjevski, N., Cusin, I., Vettor, R., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404618 · Cited by 476 · see citing works
Lundberg, J. M., Tatemoto, K., Terenius, L. Y., Hellström, P. M., Mutt, V., Hökfelt, T. G. M., & Hamberger, B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4471 · Cited by 405 · see citing works
Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 363 · see citing works
Hosker, J. P., Matthews, D. R., Rudenski, A. S., Burnett, M. A., Darling, P., Bown, E. G., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280882 · Cited by 287 · see citing works
Stock, S., Leichner, P. P., Wong, A. C. K., Ghatei, M. A., Kieffer, T. J., Bloom, S. R., & Chanoine, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1251 · Cited by 279 · see citing works
Effect of peptide YY on gastric, pancreatic, and biliary function in humans
Adrian, T. E., Savage, A. P., Sagor, G. R., Allen, J. M., Bacarese-Hamilton, A. J., Tatemoto, K., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90442-1 · Cited by 276 · see citing works
Distribution of pancreatic polypeptide and peptide YY
Ekblad, E., & Sundler, F. (2002) · Peptides · doi:10.1016/s0196-9781(01)00601-5 · Cited by 258 · see citing works
Intravenous Infusion of Peptide YY(3–36) Potently Inhibits Food Intake in Rats
Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2004) · Endocrinology · doi:10.1210/en.2004-1138 · Cited by 230 · see citing works
Effects of PYY[3–36] in rodent models of diabetes and obesity
Pittner, R. A., Moore, C. X., Bhavsar, S., Gedulin, B. R., Smith, P. A., Jodka, C. M., Parkes, D. G., Paterniti, J. R., Srivastava, V. P., & Young, A. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802696 · Cited by 217 · see citing works
To Eat or Not to Eat — How the Gut Talks to the Brain
Körner, J., & Leibel, R. L. (2003) · New England Journal of Medicine · doi:10.1056/nejmp038114 · Cited by 202 · see citing works
Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?
McIntosh, C. H. S., Demuth, H., Pospisilik, J. A., & Pederson, R. A. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.06.001 · Cited by 192 · see citing works
Upchurch, B. H., Aponte, G. W., & Leiter, A. B. (1994) · Development · doi:10.1242/dev.120.2.245 · Cited by 190 · see citing works
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186 · see citing works
Self-citationPYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
van den Hoek, A. M., Heijboer, A. C., Corssmit, E. P. M., Voshol, P. J., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1949 · Cited by 122 · see citing works
Multiple regulation of peptide YY secretion in the digestive tract
Onaga, T., Zabielski, R., & Kato, S. (2002) · Peptides · doi:10.1016/s0196-9781(01)00609-x · Cited by 120 · see citing works
Peptide YY Is Secreted after Oral Glucose Administration in a Gender-Specific Manner
Kim, B.-J., Carlson, O. D., Jang, H.-J., Elahi, D., Berry, C., & Egan, J. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0409 · Cited by 118 · see citing works
Lynch, D., Walker, M., Miller, R., & Snyder, S. H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02607.1989 · Cited by 104 · see citing works
Pieribone, V., Brodin, L., Friberg, K., Dahlstrand, J., Soderberg, C., Larhammar, D., & Hokfelt, T. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03361.1992 · Cited by 96 · see citing works
Kim, K. R., Nam, S. Y., Song, Y. D., Lim, S. K., Lee, H. C., & Huh, K. B. (1999) · Hormone Research in Paediatrics · doi:10.1159/000023319 · Cited by 86 · see citing works
Marks, J. L., & Waite, K. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00554.x · Cited by 80 · cited 1× · see citing works
“Moreover, NPY overexpression in the hypothalamus results in obesity and insulin resistance in rodents [32] and [53], whereas activation of melanocortin receptors 3 and 4 enhance insulin sensitivity and inhibition of these receptors diminish insulin sensitivity [32] and [53].”
BackgroundPeptide YY: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse.
Böttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · PubMed · Cited by 70 · see citing works
Boey, D., Heilbronn, L. K., Sainsbury, A., Laybutt, D. R., Kriketos, A. D., Herzog, H., & Campbell, L. V. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.002 · Cited by 67 · see citing works
Self-citationNeuropeptide Y promotes β-cell replication via extracellular signal-regulated kinase activation
Cho, Y. R., & Kim, C. W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.170 · Cited by 67 · see citing works
Saturable binding of circulating peptide YY in the dorsal vagal complex of rats
Hernandez, E. J., Whitcomb, D. C., Vigna, S. R., & Taylor, I. L. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.3.g511 · Cited by 67 · see citing works
Böttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · Pancreas · doi:10.1097/00006676-198906000-00002 · Cited by 64 · see citing works
Peptide YY: A Potential Therapy for Obesity
Renshaw, D. W., & Batterham, R. L. (2005) · Current Drug Targets · doi:10.2174/1389450053174523 · Cited by 62 · see citing works
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Burcelin, R., Brunner, H. R., Seydoux, J., Thorensa, B., & Pedrazzini, T. (2001) · Peptides · doi:10.1016/s0196-9781(01)00357-6 · Cited by 59 · see citing works
Upchurch, B. H., Fung, B. P., Rindi, G., Ronco, A., & Leiter, A. B. (1996) · Development · doi:10.1242/dev.122.4.1157 · Cited by 53 · see citing works
Effect of Circulating Peptide YY on Gallbladder Emptying in Humans
Hoentjen, F. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655201750422710 · Cited by 52 · see citing works
Distribution of neuropeptide Y Y1 receptors in rodent peripheral tissues
Matsuda, H., Brumovsky, P. R., Kopp, J., Pedrazzini, T., & Hökfelt, T. G. M. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10303 · Cited by 51 · see citing works
Adrian, T. E., Sagor, G. R., Savage, A. P., Bacarese-Hamilton, A. J., Hall, G. M., & Bloom, S. R. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-4-803 · Cited by 47 · see citing works
Castan‐Laurell, I., Valet, P., Larrouy, D., Voisin, T., Rémaury, A., Daviaud, D., Laburthe, M., & Lafontan, M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.1.e74 · Cited by 45 · see citing works
Effects of PYY and PP on endocrine pancreas
SZECOWKA, J., Tatemoto, K., RAJAMÄKI, G., & Efendić, S. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb07316.x · Cited by 44 · see citing works
Mechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets
Nieuwenhuizen, A. G., Karlsson, S., Fridolf, T., & Ahr�n, B. (1994) · Diabetologia · doi:10.1007/bf00400941 · Cited by 39 · see citing works
Torekov, S. S., Larsen, L. H., Glümer, C., Borch‐Johnsen, K., Jørgensen, T., Holst, J. J., Madsen, O. D., Hansen, T. F., & Pedersen, O. B. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2261 · Cited by 37 · see citing works
Evidence for a Direct Inhibitory Effect of PYY on Insulin Secretion in Rats
Bertrand, G., Gross, R., Roye, M., Ahrkn, B., & Ribes, G. (1992) · Pancreas · doi:10.1097/00006676-199209000-00013 · Cited by 33 · see citing works
Peptide YY enhances NaCl and water absorption in the rat colon in vivo
Okuno, M., Nakanishi, T., Shinomura, Y., Kiyohara, T., Ishikawa, H., & Tarui, S. (1992) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923605 · Cited by 31 · see citing works
Peptide YY does not inhibit glucose-stimulated insulin secretion in humans
Åhrén, B., & Larsson, H. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340362 · Cited by 30 · see citing works
Feedback regulation of pancreatic secretion by peptide YY
Naruse, S., Kitagawa, M., Ishiguro, H., & Hayakawa, T. (2002) · Peptides · doi:10.1016/s0196-9781(01)00612-x · Cited by 28 · see citing works
Peptide YY antagonizes beta-adrenergic-stimulated release of insulin in dogs
Greeley, G. H., Lluı́s, F., Gomez, G. A., Ishizuka, J., Holland, B., & Thompson, J. C. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.4.e513 · Cited by 24 · see citing works
Kazanjian, K. K., Towfigh, S., & McFadden, D. W. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00218-x · Cited by 19 · see citing works
Effect of Peptide YY on Insulin Release Stimulated by 2-Deoxyglucose and Neuropeptides in Dogs
Guo, Y.-S., Singh, P., DeBouno, J. F., & Thompson, J. C. (1988) · Pancreas · doi:10.1097/00006676-198804000-00003 · Cited by 18 · see citing works
Structural requirements of peptide YY for biological activity at enteric sites
YOSHINAGA, K., Mochizuki, T., Yanaihara, N., Oshima, K., Izukura, M., Kogire, M., Sumi, S., Gomez, G., Uchida, T., Thompson, J. C., et al. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.263.5.g695 · Cited by 16 · see citing works
Peptide YY Inhibits the Insulinotropic Action of Gastric Inhibitory Polypeptide
Guo, Y.-S., Singh, P., Draviam, E. J., Greeley, G. H., & Thompson, J. C. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80066-6 · Cited by 15 · see citing works
A role for islet peptide YY in the regulation of insulin secretion
Karlsson, S., & Åhrén, B. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.501245000.x · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Korner, J., Inabnet, W., Febres, G., Conwell, I. M., McMahon, D. J., Salas, R., Taveras, C., Schrope, B., & Bessler, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.79 · Cited by 338 · see citing works
Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans
Karhunen, L. J., Juvonen, K. R., Huotari, A., Purhonen, A., & Herzig, K. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.10.008 · Cited by 233 · see citing works
Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network
Cheung, G. W. C., Kokorovic, A., Lam, C., Chari, M., & Lam, T. K. T. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.005 · Cited by 179 · see citing works
Man, A. W. C., Zhou, Y., Xia, N., & Li, H. (2020) · Nutrients · doi:10.3390/nu12103054 · Cited by 136 · see citing works
The role of gut hormone peptide YY in energy and glucose homeostasis: Twelve years on
Manning, S., & Batterham, R. L. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170404 · Cited by 124 · see citing works
Cox, H. M., Tough, I. R., Woolston, A.-M., Zhang, L., Nguyen, A., Sainsbury, A., & Herzog, H. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.014 · Cited by 116 · see citing works
Self-citationIntestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Covașă, M., Stephens, R. W., Toderean, R., & Cobuz, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00082 · Cited by 114 · see citing works
Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet
ROSENBAUM, M. S., Hall, K. D., Guo, J., Ravussin, É., Mayer, L. S., Reitman, M. L., Smith, S. R., Walsh, B. T., & Leibel, R. L. (2019) · Obesity · doi:10.1002/oby.22468 · Cited by 105 · see citing works
Eid, H. M., Wright, M. L., Kumar, N. V. A., Qawasmeh, A., Hassan, S. T. S., Mocan, A., Nabavi, S. M., Rastrelli, L., Atanasov, A. G., & Haddad, P. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00387 · Cited by 106 · see citing works
Bariatric surgery for type 2 diabetes: Weighing the impact for obese patients
Kashyap, S. R., Gatmaitan, P., Brethauer, S. A., & Schauer, P. R. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77a.09135 · Cited by 103 · see citing works
Scott, W. R., & Batterham, R. L. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2011 · Cited by 99 · see citing works
Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity
Song, Z., Wang, Y., Zhang, F., Yao, F., & Sun, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112768 · Cited by 86 · see citing works
Leveraging the Gut to Treat Metabolic Disease
Gimeno, R. E., Briere, D. A., & Seeley, R. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.014 · Cited by 82 · see citing works
Morı́nigo, R., Vidal, J., Lacy, A. M., Delgado, S., Casamitjana, R., & Gomis, R. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31815f6e77 · Cited by 85 · see citing works
Khan, D., Vasu, S., Moffett, R. C., Irwin, N., & Flatt, P. R. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.020 · Cited by 85 · see citing works
Gut Hormones and Energy Balance, The Future for Obesity Therapy?
Meiliana, A., & Wijaya, A. (2009) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v1i3.99 · Cited by 78 · see citing works
Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man
Witte, A.-B., Grybäck, P., Holst, J. J., Hilsted, L., Hellström, P. M., Jacobsson, H., & Schmidt, P. T. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.07.013 · Cited by 72 · see citing works
Ortiz, A. A., Milardo, L. F., DeCarr, L. B., Buckholz, T. M., Mays, M. R., Claus, T. H., Livingston, J. N., Mahle, C. D., & Lumb, K. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125211 · Cited by 69 · see citing works
Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance
Chandarana, K., Gelegen, Ç., Irvine, E. E., Choudhury, A. I., Amouyal, C., Andréelli, F., Withers, D. J., & Batterham, R. L. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.001 · Cited by 64 · see citing works
Keenan, M. J., Martin, R. J., Raggio, A. M., McCutcheon, K. L., Brown, I. L., Birkett, A. M., Newman, S. S., Skaf, J. S., Hegsted, M., Tulley, R. T., et al. (2012) · Lifestyle Genomics · doi:10.1159/000335319 · Cited by 53 · see citing works
Shi, Y., Loh, K., Bensellam, M., Lee, K., Zhai, L., Lau, J., Cantley, J., Luzuriaga, J., Laybutt, D. R., & Herzog, H. (2015) · Endocrinology · doi:10.1210/en.2015-1168 · Cited by 49 · see citing works
Self-citationThe satiety hormone peptide YY as a regulator of appetite
Vincent, R. P., & le Roux, C. W. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048488 · Cited by 51 · see citing works
García-Gutiérrez, E., O’Mahony, A. K., dos Santos, R. S., Marroquí, L., & Cotter, P. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2401654 · Cited by 42 · see citing works
Doyle, K. L., Karl, T., Hort, Y., Duffy, L., Shine, J., & Herzog, H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05188.x · Cited by 41 · see citing works
Self-citationEndogenous PYY and GLP ‐1 mediate l ‐glutamine responses in intestinal mucosa
Joshi, S., Tough, I. R., & Cox, H. M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12352 · Cited by 38 · see citing works
Lenz, A., & Diamond, F. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f43a5b · Cited by 38 · see citing works
Voortman, T., Hendriks, H., Witkamp, R. F., & Wortelboer, H. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2045697 · Cited by 34 · see citing works
Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone
Chen, J., Nouzová, M., Noriega, F. G., & Tatar, M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2411987121 · Cited by 32 · see citing works
Liu, S., Zhang, G., Wang, L., Sun, D., Chen, W., Yan, Z., Sun, Y. S., & Hu, S. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31826c3866 · Cited by 31 · see citing works
Rigamonti, A. E., Agosti, F., Compri, E., Giunta, M., Marazzi, N., Müller, E. E., Cella, S. G., & Sartório, A. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0867 · Cited by 32 · see citing works
Nilsson, A., Johansson-Boll, E., Sandberg, J., & Björck, I. (2016) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2016.06.006 · Cited by 30 · see citing works
Altered Hypothalamic Protein Expression in a Rat Model of Huntington's Disease
Cong, W., Cai, H., Wang, R., Daimon, C. M., Maudsley, S. R., Raber, K. A., Canneva, F., von Hörsten, S., & Martin, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047240 · Cited by 27 · see citing works
Peptide YY levels are associated with appetite suppression in response to long-chain fatty acids
Stoeckel, L. E., Weller, R. E., Giddings, M. J., & Cox, J. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.08.018 · Cited by 27 · see citing works
Role of enteroendocrine hormones in appetite and glycemia
Ricardo-Silgado, M. L., MCRAE, A. N., & Acosta, A. J. (2021) · Obesity Medicine · doi:10.1016/j.obmed.2021.100332 · Cited by 28 · see citing works
Modulatory Role of PYY in Transport and Metabolism of Cholesterol in Intestinal Epithelial Cells
Grenier, É., Garofalo, C., DELVIN, E. E., & Levy, E. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040992 · Cited by 26 · see citing works
RetractedUkkola, O. H., Puurunen, V.-P., Piira, O.-P., Niva, J., Lepojärvi, E. S., Tulppo, M. P., & Huikuri, H. V. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.05.006 · Cited by 26 · see citing works
Reid, A. M. A., Wilson, P. W., Caughey, S. D., Dixon, L., D’Eath, R. B., Sandilands, V., Boswell, T., & Dunn, I. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.07.002 · Cited by 26 · see citing works
Dixon, L., Dunn, I., Brocklehurst, S., Baker, L. H., Boswell, T. C., Caughey, S. D., Reid, A. M. A., Sandilands, V., Wilson, P. W., & D’Eath, R. B. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101838 · Cited by 22 · see citing works
Neuropeptide Y and peptide YY have distinct roles in adult mouse olfactory neurogenesis
Doyle, K. L., Hort, Y., Herzog, H., & Shine, J. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23008 · Cited by 19 · see citing works
Self-citationVasto, S., Gaudio, F. D., Raso, M., Sabatino, L., Caldarella, R., PASQUALE, C. D., Rosa, L. D., & Baldassano, S. (2022) · Nutrients · doi:10.3390/nu14071351 · Cited by 18 · see citing works
Ingerslev, A. K., Mutt, S. J., Lærke, H. N., Hedemann, M. S., Theil, P. K., Nielsen, K. L., Jørgensen, H. J. H., Herzig, K., & Knudsen, K. E. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185927 · Cited by 17 · see citing works
Crescenti, A., Solà, R., Valls, R. M., Anguera, A., & Arola, L. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0303-9 · Cited by 17 · see citing works
Wang, Q., & Huang, X. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.029 · Cited by 17 · see citing works
Role of peptide hormones in the adaptation to altered dietary protein intake
Rose, A. J. (2019) · Nutrients · doi:10.3390/nu11091990 · Cited by 15 · see citing works
Potential therapies based on antidiabetic peptides
Billyard, T., McTernan, P. G., & Kumar, S. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.07.006 · Cited by 15 · see citing works
Correction: Altered Hypothalamic Protein Expression in a Rat Model of Huntington's Disease
Cong, W., Cai, H., Wang, R., Daimon, C. M., Maudsley, S. R., Raber, K. A., Canneva, F., von Hörsten, S., & Martin, B. (2012) · PLoS ONE · doi:10.1371/annotation/677c26e3-ce52-4837-853a-63c4ed7d72c0 · Cited by 13 · see citing works
E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
Chavkin, T. A., Pham, L. D., & Kostic, A. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-02431-8 · Cited by 12 · see citing works
Targeting Islets: Metabolic Surgery Is More than a Bariatric Surgery
Chen, X., Zhang, J., & Zhou, Z. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03979-1 · Cited by 12 · see citing works
Fang, C., Shen, Y., Ma, Z., Li, Y., Zhang, J., Liu, C., & Ye, Y. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300797 · Cited by 11 · see citing works
Zhang, L., Clark, T., Gopalasingam, G., Neely, G. G., & Herzog, H. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102149 · Cited by 10 · see citing works
Self-citationSignals Arising from the Gastrointestinal Tract that Affect Food Intake
Purhonen, A. (2008) · Cited by 10 · see citing works
Zhao, W., Zhou, Y., Yuan, Y., Fan, Z., Wu, Y., Liu, A., & Lu, X. (2020) · Nutrients · doi:10.3390/nu12092759 · Cited by 8 · see citing works
Zhou, J., Li, X., Zhu, X., Sun, J., Qiu, Q., Huang, W., & Qian, H. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12726 · Cited by 8 · see citing works
Gut Microbiome Dysbiosis in Metabolic Syndrome: Current Evidence and Emerging Perspectives
Shehata, F., Dwyer, K. M., McGee, S. L., & Rivera, L. R. (2026) · Nutrients · doi:10.3390/nu18101540 · Cited by 7 · see citing works
Ji, T., Xu, G., Wu, Y., Wang, Y., Xiao, C., Zhang, B., Xu, B., & Xu, F. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03987 · Cited by 6 · see citing works
Ninjin'yoeito, a herbal medicine, enhances glucose tolerance in mice
Zhang, L., Gopalasingam, G., & Herzog, H. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102150 · Cited by 6 · see citing works
Self-citationBottino, R., Carbone, A., Formisano, T., D’Elia, S., Orlandi, M., Sperlongano, S., Molinari, D., Castaldo, P., Palladino, A., Barbareschi, C., et al. (2023) · Life · doi:10.3390/life13071552 · Cited by 5 · see citing works
Gut Peptide Alterations in Type 2 Diabetes and Obesity: A Narrative Review
Tzeravini, E., Simati, S., Anastasiou, I. A., Dalamaga, Μ., & Kokkinos, A. D. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00687-7 · Cited by 4 · see citing works
The role of PYY in improving insulin resistance
Liu, C., Na, R., Zhang, H., & Ma, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1784709 · Cited by 4 · see citing works
Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders
Khin, K. L. S., Youssefi, S., Yang, Q., Page, A. J., Nateri, A. S., Eldeghaidy, S., Young, R. L., & IDRIS, I. R. (2026) · Nutrients · doi:10.3390/nu18050759 · Cited by 4 · see citing works
Lower Gut Hormones and Health Effects Associated with Consumption of Fermentable Fibers
Keenan, M. J., Zhou, J. F., Senevirathene, R., Janes, M. E., & Martin, R. J. (2010) · doi:10.1002/9780470958186.ch4 · Cited by 3 · see citing works
Effect of Resistant Starch on Microbial Content of the Intestinal Tract
Senevirathne, R. N. (2010) · doi:10.31390/gradschool_dissertations.2717 · Cited by 2 · see citing works
Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormonePreprint
Chen, J., Nouzová, M., Noriega, F. G., & Tatar, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.26.600832 · Cited by 2 · see citing works
Adipocytokine levels in patients with atherosclerosis and high triglyceride – glucose index
Garbuzova, E. V., Шрамко, В. С., Kashtanova, E. V., Polonskaya, Y. V., Stakhneva, E. M., Кургузов, А. В., Chernyavskiy, A. М., & Ragino, Y. I. (2024) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2024-3-34-41 · Cited by 1 · see citing works
Mammalian Peptide Hormones: Biosynthesis and Inhibition
Brand, K., & Beck‐Sickinger, A. G. (2009) · doi:10.1002/9783527631780.ch13 · Cited by 1 · see citing works
Glucose metabolism in the critically ill.
Deane, A. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Approche multifonctionnelle mitochondriale par puce à ADN dédiée
Arvier, M. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)
Cox, A. J., West, N. P., & Cripps, A. W. (2016) · doi:10.1002/9781118924853.ch17
Neuroendocrine Control of Hepatic Gluconeogenesis
Mao, Z., & Zhang, W. (2017) · InTech eBooks · doi:10.5772/67535
Manipulating the Gut Microbiome to Improve Health
Chavkin, T. A. (2021) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
(2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f4f084
Holzer, P. D., & Farzi, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65827-0
Malik, D., Narayanasamy, N., Pratyusha, V. A., Thakur, J., & Sinha, N. (2023) · Springer eBooks · doi:10.1007/978-981-19-4150-4_7
Cox, A. J., West, N. P., & Cripps, A. W. (2024) · doi:10.1002/9781119697473.ch19
Holzer, P. D., & Farzi, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00401-5
- Authors
- Boey, D., Sainsbury, A., & Herzog, H.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Corresponding author
- Boey, Dana
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 28
- Issue
- 2
- Pages
- 390-395
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2060154835
- Cited by
- 77
- References
- 54
- Citations by year
- 2026: 4 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 1 · 2013: 4 · 2012: 10
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- peptide YY, glucose homeostasis, insulin secretion, insulin sensitivity, gastrointestinal hormones, satiety, dietary intake, body weight regulation, gastrointestinal function
- MeSH terms
- Animals, Clinical Trials as Topic, Glucose, Homeostasis, Humans, Insulin Resistance, Peptide YY
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review