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Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.
Open accessAbstract
Human allospecific cytotoxic T lymphocyte lines were established by weekly stimulation of peripheral blood lymphocytes with allogeneic Epstein-Barr virus-transformed lymphoblastoid cell lines in the presence of interleukin 2. The cytotoxic T lymphocyte lines were stimulated by either JY (which expresses HLA-A,B and -DR) or Daudi (which expresses HLA-DR but not -A,B antigens). Specificity of the effector cell lines was determined by antibody blocking and by patterns of cytolysis against a panel of target cell lines. The phenotype of the effector cells was identified by both negative (antibody and complement lysis) and positive (fluorescence-activated cell sorter) selection. The anti-JY lines only recognized targets bearing HLA-A2, B7 antigens and were composed exclusively of OKT4-8+ effector cells. The anti-Daudi lines, on the other hand, specifically recognized targets bearing DR6 and eventually contained only OKT4+8- cells. Thus, stimulation by Daudi cells can result in the generation of OKT4+ CTL lines that are allospecific for DR6 antigen.
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Cited by
Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgdon, J. C., Schlossman, S. F., & Reinherz, E. L. (1983) · The Journal of experimental medicine · doi:10.1084/jem.157.2.705 · Cited by 837
Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
Hauser, S. L., Bhan, A. K., Gilles, F., Kemp, M., Kerr, C., & Weiner, H. L. (1986) · Annals of Neurology · doi:10.1002/ana.410190610 · Cited by 399
Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?
Juno, J. A., van Bockel, D., Kent, S. J., Kelleher, A. D., Zaunders, J. J., & Munier, C. M. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00019 · Cited by 195
Hayashi, T., Morimoto, C., Burks, J. S., Kerr, C., & Hauser, S. L. (1988) · Annals of Neurology · doi:10.1002/ana.410240408 · Cited by 100
Metadata
- Authors
- Krensky, A. M., Reiss, C. S., Mier, J. W., Strominger, J. L., & Burakoff, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-04
- Volume
- 79
- Issue
- 7
- Pages
- 2365-2369
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026947098
- Cited by
- 240
- References
- 0
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. https://app.cochat.ai/papers/10.1073/pnas.79.7.2365
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- Krensky, A. M., Reiss, C. S., Mier, J. W., Strominger, J. L., & Burakoff, S. J. (1982). Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.7.2365
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
