The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Infidelity of DNA synthesis associated with bypass of apurinic sites.
Open accessAbstract
The mutagenic potential of apurinic sites in vivo has been studied by transfection of depurinated phi X174 DNA containing amber mutations into SOS-induced Escherichia coli spheroplasts. Mutagenicity is abolished by treatment of the depurinated DNA with an apurinic endonuclease from Hela cells, establishing the apurinic site as the mutagenic lesion. The frequency of copying apurinic sites in vitro was analyzed by measuring the extent of DNA synthesis using E. coli DNA polymerase I and avian myeloblastosis DNA polymerase. The inhibition of DNA synthesis by apurinic sites was less with avian myeloblastosis DNA polymerase, suggesting that this error-prone enzyme copies apurinic sites with greater frequency. Consistent with this conclusion is the observation that, upon transfection into (normal) spheroplasts, the reversion frequency of depurinated phi X174 am3 DNA copied with avian myeloblastosis virus DNA polymerase is much greater than that of the same DNA copied with E. coli DNA polymerase I. Sequence analysis of the DNA of 33 revertant phage produced by depurination indicates a preference for incorporation of deoxyadenosine opposite putative apurinic sites. The combined results indicate that mutagenesis resulting from apurinic sites is associated with bypass of these noncoding lesions during DNA synthesis.
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Cites
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The nucleotide sequence of bacteriophage φX174
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DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair
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All oxygens in nucleic acids react with carcinogenic ethylating agents
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Cited by
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.
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Self-citationMutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
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Genetic analyses from ancient DNA
Pääbo, S., Poinar, H., Serre, D., Jaenicke-Després, V., Hebler, J., Rohland, N., Kuch, M., Krause, J., Vigilant, L., & Hofreiter, M. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143214 · Cited by 1,333
MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES
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Metadata
- Authors
- Schaaper, R. M., Kunkel, T. A., & Loeb, L. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-01
- Volume
- 80
- Issue
- 2
- Pages
- 487-491
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063134544
- Cited by
- 305
- References
- 22
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Schaaper, R. M., Kunkel, T. A., & Loeb, L. A. (1983). Infidelity of DNA synthesis associated with bypass of apurinic sites. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.2.487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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