The DOI matches its Crossref record.
Depurination causes mutations in SOS-induced cells.
Open accessAbstract
Introduction of apurinic sites into phi X174 am3 DNA leads to loss of biological activity when measured in a transfection assay. For single-stranded DNA, approximately one apurinic site constitutes a lethal hit; for double-stranded (RFI) DNA, approximately 3.5 hits per strand are lethal. When the reversion frequency of am3 DNA is measured, no increase due to depurination is observed above the background level. However, a large increase in reversion frequency is observed when the same DNA is assayed by using spheroplasts derived from bacteria previously exposed to UV light. The results suggest that apurinic sites are impediments to a replicating DNA polymerase; however, nucleotides can be incorporated opposite these sites under SOS-induced conditions. We estimate the frequency of mutagenesis per apurinic site to be less than 1 in 1400 in normal spheroplasts and 1 in 100 in SOS-induced spheroplasts.
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Citations
Cited by
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
Walker, G. C. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.1.60-93.1984 · Cited by 1,770
MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES
Loeb, L. A., & Preston, B. D. (1986) · Annual Review of Genetics · doi:10.1146/annurev.ge.20.120186.001221 · Cited by 901
Self-citationEnzymatic Processing of Radiation-Induced Free Radical Damage in DNA
Wallace, S. S. (1998) · Radiation Research · doi:10.2307/3579809 · Cited by 334
Sagher, D., & Strauss, B. (1983) · Biochemistry · doi:10.1021/bi00288a026 · Cited by 320
Infidelity of DNA synthesis associated with bypass of apurinic sites.
Schaaper, R. M., Kunkel, T. A., & Loeb, L. A. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.487 · Cited by 305
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Metadata
- Authors
- Schaaper, R. M., & Loeb, L. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-03
- Volume
- 78
- Issue
- 3
- Pages
- 1773-1777
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975723497
- Cited by
- 186
- References
- 0
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
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