Cited by 1,333Forensic and Genetic ResearchGenetic diversity and population structurePaleopathology and ancient diseases

Genetic analyses from ancient DNA

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Pääbo, Svante, Poinar, Hendrik, Serre, David, Jaenicke-Després, Viviane, Hebler, Juliane, Rohland, Nadin, Kuch, Melanie, Krause, Johannes +2 more·2004·Annual Review of Genetics

Abstract

About 20 years ago, DNA sequences were separately described from the quagga (a type of zebra) and an ancient Egyptian individual. What made these DNA sequences exceptional was that they were derived from 140- and 2400-year-old specimens. However, ancient DNA research, defined broadly as the retrieval of DNA sequences from museum specimens, archaeological finds, fossil remains, and other unusual sources of DNA, only really became feasible with the advent of techniques for the enzymatic amplification of specific DNA sequences. Today, reports of analyses of specimens hundreds, thousands, and even millions of years old are almost commonplace. But can all these results be believed? In this paper, we critically assess the state of ancient DNA research. In particular, we discuss the precautions and criteria necessary to ascertain to the greatest extent possible that results represent authentic ancient DNA sequences. We also highlight some significant results and areas of promising future research.

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  1. Schmitz RW, Serre D, Bonani G, Feine S, Hillgruber F, et al. 2002. The Ne- andertal type site revisited: interdis- ciplinary investigations of skeletal re- mains from the Neander Valley, Germany. Proc. Natl. Acad. Sci. USA 99:13342- 47 129.
  2. Trinkaus E. 2001. The Neandertal para- dox. In Neanderthals and Modern Hu- mans in Late Pleistocene Eurasia, ed. C Finlayson, pp. 73-74. Gibraltar: Gibraltar Museum P Ä ÄBO ET AL. 150. Trinkaus E, Duarte C. 2000. The hybrid child from Portugal. Sci. Am. 282:102-3 151.

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Authors
Pääbo, S., Poinar, H., Serre, D., Jaenicke-Després, V., Hebler, J., Rohland, N., Kuch, M., Krause, J., Vigilant, L., & Hofreiter, M.
Affiliations
Max Planck Institute for Evolutionary Anthropology (DE)
Venue
Annual Review of Genetics
Published
2004-12-01
Volume
38
Issue
1
Pages
645-679
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2101294025
Cited by
1,333
References
176
Citations by year
2026: 34 · 2025: 51 · 2024: 38 · 2023: 39 · 2022: 46 · 2021: 56 · 2020: 57 · 2019: 60 · 2018: 116 · 2017: 60 · 2016: 84 · 2015: 73 · 2014: 77 · 2013: 72 · 2012: 64
FWCI
4.71
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Social Sciences › Arts and Humanities › Archeology › Paleopathology and ancient diseases
Keywords
ancient DNA, museum specimens, archaeological finds, fossils, quagga
MeSH terms
Animals, Animals, Domestic, Archaeology, Behavior, Cloning, Molecular, Deamination, Diet, DNA, DNA Damage, DNA, Mitochondrial, Fossils, Humans, Mummies, Phylogeny, Hominidae, Sequence Analysis, DNA, Geologic Sediments

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