The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.
Open accessAbstract
Antisera raised against synthetic dynorphin or [Leu5]enkephalin demonstrate immunostaining in hippocampal mossy fibers and in dentate granule cells. However, dynorphin immunoreactivity (ir) appears to be denser in immunocytochemical preparations and is quantitatively greater by radioimmunoassay than enkephalin-ir. Immunostaining with dynorphin antisera is eliminated by adsorption with 1-100 microM dynorphin-17 whereas immunostaining with enkephalin antisera is eliminated by adsorption with 1-100 microM [Leu5]enkephalin, dynorphin-17, dynorphin-(1-13), or alpha-neo-endorphin. Intrahippocampal colchicine injections, which selectively destroy dentate granule cells, significantly decrease the dynorphin-ir and enkephalin-ir levels in rat hippocampus. Intraventricularly administered kainic acid, which selectively destroys CA3-4 pyramidal cells, results in an increase of enkephalin immunostaining in mossy fibers and a significant increase in enkephalin-ir by radioimmunoassay in whole hippocampus. The enkephalin-ir cells and fibers in entorhinal/perirhinal cortex, which innervate rat hippocampus and dentate gyrus, do not contain dynorphin-ir.
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Cites
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Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
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Cited by
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,717
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Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
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Metadata
- Authors
- McGinty, J. F., Henriksen, S. J., Goldstein, A., Terenius, L., & Bloom, F. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-01
- Volume
- 80
- Issue
- 2
- Pages
- 589-593
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049981218
- Cited by
- 290
- References
- 22
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity. https://app.cochat.ai/papers/10.1073/pnas.80.2.589
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- McGinty, J. F., Henriksen, S. J., Goldstein, A., Terenius, L., & Bloom, F. E. (1983). Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.2.589
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