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Cited by 295

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.

Open access
Smith, G L, Murphy, B R, Moss, B·1983·Proceedings of the National Academy of Sciences

Abstract

A DNA copy of the influenza virus hemagglutinin gene, derived from influenza virus A/Jap/305/57 (H2N2) was inserted into the genome of vaccinia virus under the control of an early vaccinia virus promoter. Tissue culture cells infected with the purified recombinant virus synthesized influenza hemagglutinin, which was glycosylated and transported to the cell surface where it could be cleaved with trypsin into HA1 and HA2 subunits. Rabbits and hamsters inoculated intradermally with recombinant virus produced circulating antibodies that inhibited hemagglutination by influenza virus. Furthermore, vaccinated hamsters achieved levels of antibody similar to those obtained upon primary infection with influenza virus and were protected against respiratory infection with the A/Jap/305/57 influenza virus.

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Crossref · 10.1073/pnas.80.23.7155

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Metadata

Authors
Smith, G. L., Murphy, B. R., & Moss, B.
Venue
Proceedings of the National Academy of Sciences
Published
1983-12
Volume
80
Issue
23
Pages
7155-7159
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2077195343
Cited by
295
References
1
FWCI
31.05
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters. https://app.cochat.ai/papers/10.1073/pnas.80.23.7155
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Smith, G. L., Murphy, B. R., & Moss, B. (1983). Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.23.7155

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.