The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
Open accessAbstract
By inducing mouse thymomas with carcinogens and gamma-radiation, we have studied the potential of tumor DNA to induce foci in rodent fibroblasts. A high percentage of the tumors used transformed the cultured cells, and the oncogenic phenotype segregated with extra copies of the c-ras gene family. There appears to be selectivity in the activated gene because so far all analyzed tumors induced by carcinogen have activated the N-ras gene, and those induced by radiation have activated the K-ras gene. The K-ras gene is the cellular counterpart of the viral ras oncogene in Kirsten murine sarcoma virus, but the N-ras has not yet been found in a retrovirus. The transformed cells have a marked increase in expression of the oncogene at the RNA and protein level. This model system might be a powerful tool in the study of leukemogenesis.
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Cites
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Cited by
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902
Ras oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467
Molecular cloning of a new transforming gene from a chemically transformed human cell line
Cooper, C. S., Park, M., Blair, D. G., Tainsky, M. A., Huebner, K., Croce, C. M., & Vande Woude, G. F. (1984) · Nature · doi:10.1038/311029a0 · Cited by 989
Oncogene Activation in Chemical Carcinogenesis
(1988) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60222-5 · Cited by 388
Wildtype Kras2 can inhibit lung carcinogenesis in mice
Zhang, Z., Wang, Y., Vikis, H. G., Johnson, L., Liu, G., Li, J., Anderson, M. W., Sills, R. C., Hong, H. L., Devereux, T. R., et al. (2001) · Nature Genetics · doi:10.1038/ng721 · Cited by 296
Metadata
- Authors
- Guerrero, I., Calzada, P., Mayer, A., & Pellicer, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-01
- Volume
- 81
- Issue
- 1
- Pages
- 202-205
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971972605
- Cited by
- 188
- References
- 1
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. https://app.cochat.ai/papers/10.1073/pnas.81.1.202
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- Guerrero, I., Calzada, P., Mayer, A., & Pellicer, A. (1984). A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.1.202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
