Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 14,678 · see citing works

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

Benton, W. D., & Davis, R. W. (1977) · Science · doi:10.1126/science.322279 · Cited by 4,660 · see citing works

Mechanism of activation of a human oncogene

Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393 · see citing works

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

Reddy, E. P., Reynolds, R. K., Santos, E., & Barbacid, M. (1982) · Nature · doi:10.1038/300149a0 · Cited by 1,391 · see citing works

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H., & Goeddel, D. V. (1983) · Nature · doi:10.1038/302033a0 · Cited by 997 · see citing works

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

Parada, L. F., Tabin, C. J., Shih, C., & Weinberg, R. A. (1982) · Nature · doi:10.1038/297474a0 · Cited by 947 · see citing works

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

Der, C. J., Krontiris, T. G., & Cooper, G. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3637 · Cited by 785 · see citing works

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

Ellis, R. W., DeFeo, D., Shih, T. Y., Gonda, M. A., Young, H. A., Tsuchida, N., Lowy, D. R., & Scolnick, E. M. (1981) · Nature · doi:10.1038/292506a0 · Cited by 723 · see citing works

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

Taparowsky, E. J., Suard, Y. M. L., Fasano, O., Shimizu, K., Goldfarb, M. P., & Wigler, M. H. (1982) · Nature · doi:10.1038/300762a0 · Cited by 703 · see citing works

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

Santos, E., Tronick, S. R., Aaronson, S. A., Pulciani, S., & Barbacid, M. (1982) · Nature · doi:10.1038/298343a0 · Cited by 624 · see citing works

Cellular Transforming Genes

Cooper, G. M. (1982) · Science · doi:10.1126/science.6285471 · Cited by 597 · see citing works

[19] In Vitro packaging of λ and cosmid DNA

Höhn, B. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)68021-7 · Cited by 532 · see citing works

Genetic and physical linkage of exogenous sequences in transformed cells

Perucho, M., Hanahan, D., & Wigler, M. H. (1980) · Cell · doi:10.1016/0092-8674(80)90178-6 · Cited by 486 · see citing works

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

Goldfarb, M. P., Shimizu, K., Perucho, M., & Wigler, M. H. (1982) · Nature · doi:10.1038/296404a0 · Cited by 484 · see citing works

Oncogenes in solid human tumours

Pulciani, S., Santos, E., Lauver, A. V., Long, L. K., Aaronson, S. A., & Barbacid, M. (1982) · Nature · doi:10.1038/300539a0 · Cited by 479 · see citing works

Human-tumor-derived cell lines contain common and different transforming genes

Perucho, M., Goldfarb, M. P., Shimizu, K., Lama, C., Fogh, J., & Wigler, M. H. (1981) · Cell · doi:10.1016/0092-8674(81)90388-3 · Cited by 447 · see citing works

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

Hall, A., Marshall, C. J., Spurr, N. K., & Weiss, R. A. (1983) · Nature · doi:10.1038/303396a0 · Cited by 438 · see citing works

EK2 Derivatives of Bacteriophage Lambda Useful in the Cloning of DNA from Higher Organisms: The λgt WES System

Leder, P., Tiemeier, D. C., & Enquist, L. W. (1977) · Science · doi:10.1126/science.322278 · Cited by 409 · see citing works

Three human transforming genes are related to the viral ras oncogenes.

Shimizu, K., Goldfarb, M. P., Suard, Y. M. L., Perucho, M., Li, Y., Kamata, T., Feramisco, J. R., Stavnezer, E., Fogh, J. M., & Wigler, M. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.8.2112 · Cited by 389 · see citing works

A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes

Loenen, W. A. M., & Brammar, W. J. (1980) · Gene · doi:10.1016/0378-1119(80)90054-2 · Cited by 378 · see citing works

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

Shimizu, K., Birnbaum, D., Ruley, M. A., Fasano, O., Suard, Y. M. L., Edlund, L., Taparowsky, E. J., Goldfarb, M. P., & Wigler, M. H. (1983) · Nature · doi:10.1038/304497a0 · Cited by 373 · see citing works

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

Yuasa, Y., Srivastava, S. K., Dunn, C. Y., Rhim, J. S., Reddy, E. P., & Aaronson, S. A. (1983) · Nature · doi:10.1038/303775a0 · Cited by 366 · see citing works

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

McGrath, J. P., Capon, D. J., Smith, D. H., Chen, E. Y., Seeburg, P. H., Goeddel, D. V., & Levinson, A. D. (1983) · Nature · doi:10.1038/304501a0 · Cited by 358 · see citing works

The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors

Murray, M. J., Cunningham, J. M., Parada, L. F., Dautry, F., Lebowitz, P., & Weinberg, R. A. (1983) · Cell · doi:10.1016/0092-8674(83)90017-x · Cited by 337 · see citing works

Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.

Chang, E. H., Gonda, M. A., Ellis, R. W., Scolnick, E. M., & Lowy, D. R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.16.4848 · Cited by 324 · see citing works

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

Tsuchida, N., Ryder, T., & Ohtsubo, E. (1982) · Science · doi:10.1126/science.6287573 · Cited by 272 · see citing works

Three different human tumor cell lines contain different oncogenes

Murray, M. J., Shilo, B., Shih, C., Cowing, D. W., Hsu, H.-W., & Weinberg, R. A. (1981) · Cell · doi:10.1016/0092-8674(81)90054-4 · Cited by 236 · see citing works

Isolation of the chicken thymidine kinase gene by plasmid rescue

Perucho, M., Hanahan, D., Lipsich, L. A., & Wigler, M. H. (1980) · Nature · doi:10.1038/285207a0 · Cited by 189 · see citing works

Use of transfection to analyze genetic information and malignant transformation

Weinberg, R. A. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(81)90003-2 · Cited by 58 · see citing works

Thirty-four Lines of Six Human Tumor Categories Established in Nude Mice 2 3

Fogh, J., Tiso, J., Orfeo, T., Sharkey, F. E., Daniels, W. P., & Fogh, J. M. (1980) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/64.4.745 · Cited by 45 · see citing works

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,100 · see citing works

Ras oncogenes: split personalities

Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467 · see citing works

Understanding and targeting resistance mechanisms in NSCLC

Rotow, J. K., & Bivona, T. G. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.84 · Cited by 978 · see citing works

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

Kasinski, A. L., & Slack, F. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3166 · Cited by 934 · see citing works

The ras gene family and human carcinogenesis

Bos, J. L. (1988) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(88)90004-8 · Cited by 774 · see citing works

Evolution of tumours and the impact of molecular oncology

Klein, G., & Klein, E. (1985) · Nature · doi:10.1038/315190a0 · Cited by 655 · see citing works

Biological properties of human c-Ha-ras1 genes mutated at codon 12

Seeburg, P. H., Colby, W. W., Capon, D. J., Goeddel, D. V., & Levinson, A. D. (1984) · Nature · doi:10.1038/312071a0 · Cited by 567 · see citing works

Mutational Activation of the K-rasOncogene

Rodenhuis, S., van de Wetering, M. L., Mooi, W. J., Evers, S. G., van Zandwijk, N., & Bos, J. L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198710083171504 · Cited by 532 · see citing works

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

Ross, J. S., Wang, K., Gay, L. M., Al-Rohil, R. N., Rand, J. V., Jones, D., Lee, H. J., Sheehan, C. E., Otto, G. A., Palmer, G. A., et al. (2014) · The Oncologist · doi:10.1634/theoncologist.2013-0352 · Cited by 453 · see citing works

Malignant Activation of a K- <i>ras</i> Oncogene in Lung Carcinoma But Not in Normal Tissue of the Same Patient

Santos, E., Martin-Zanca, D., Reddy, E. P., Pierotti, M. A., Della Porta, G., & Barbacid, M. (1984) · Science · doi:10.1126/science.6695174 · Cited by 418 · see citing works

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

Bos, J. L., Toksoz, D., Marshall, C. J., Vries, M. V., Veeneman, G. H., van der Eb, A. J., BOOM, J. H. V., Janssen, J. W. G., & Steenvoorden, A. C. M. (1985) · Nature · doi:10.1038/315726a0 · Cited by 362 · see citing works

Oncogene Amplification in Tumor Cells

Alitalo, K. K., & Schwab, M. (1986) · Advances in cancer research · doi:10.1016/s0065-230x(08)60201-8 · Cited by 340 · see citing works

A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.

Winter, E., Yamamoto, F., Almoguera, C., & Perucho, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7575 · Cited by 310 · see citing works

BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum

Yang, S., Farraye, F. A., Mack, C., Posnik, O., & O’Brien, M. J. (2004) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000141404.56839.6a · Cited by 281 · see citing works

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

Peinado, M. A., Malkhosyan, S. R., Velázquez, A., & Perucho, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10065 · Cited by 257 · see citing works

Ras Farnesyltransferase: A New Therapeutic Target

Leonard, D. M. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970226l · Cited by 241 · see citing works

Comparative analysis of mutations in the p53 and K‐ras genes in pancreatic cancer

Berrozpe, G., Schaeffer, J., Peinado, M. A., Real, F. X., & Perucho, M. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580207 · Cited by 236 · see citing works

Monoclonal antibodies define differential ras gene expression in malignant and benign colonic diseases

Thor, A. D., Hand, P. H., Wunderlich, D. A., Caruso, A., Muraro, R., & Schlom, J. (1984) · Nature · doi:10.1038/311562a0 · Cited by 222 · see citing works

Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.

Theillet, C. G., Lidereau, R., Escot, C., Hutzell, P., Brunet, M., Gest, J., Schlom, J., & Callahan, R. (1986) · PubMed · Cited by 213 · see citing works

Transformation of Human Bronchial Epithelial Cells Transfected by Harvey ras Oncogene

Yoakum, G. H., Lechner, J. F., Gabrielson, E. W., Korba, B. E., Malan-Shibley, L. B., Willey, J. C., Valerio, M. G., Shamsuddin, A. M., Trump, B. F., & Harris, C. C. (1985) · Science · doi:10.1126/science.3975607 · Cited by 191 · see citing works

Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

Manne, V., Bekesi, E., & Kung, H. F. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.376 · Cited by 177 · see citing works

Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse.

Reynolds, S. H., Stowers, S. J., Maronpot, R. R., Anderson, M. W., & Aaronson, S. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.1.33 · Cited by 176 · see citing works

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

Guerrero, I., Villasanté, A., Corces, V. G., & Pellicer, À. (1984) · Science · doi:10.1126/science.6474169 · Cited by 175 · see citing works

Biochemical activities of the ParA partition protein of the P1 plasmid

Davis, M. A., Martin, K., & Austin, S. J. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01552.x · Cited by 165 · see citing works

Drugging KRAS: Current perspectives and state-of-art review

Parikh, K., Banna, G., Liu, S. V., Friedlaender, A., Desai, A., Subbiah, V., & Addeo, A. (2022) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-022-01375-4 · Cited by 164 · see citing works

Three different mutations in codon 61 of the human N-rasgene detected by synthetic oligonucleotide hybridization

Bos, J. L., Vries, M. V.-D., Jansen, A. M., Veeneman, G. H., BOOM, J. H. V., & van der Eb, A. J. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.23.9155 · Cited by 162 · see citing works

Genetics of neuroendocrine and carcinoid tumours.

Leotlela, P. D., Jauch, A. T., Holtgreve-Grez, H., & Thakker, R. V. (2003) · Endocrine Related Cancer · doi:10.1677/erc.0.0100437 · Cited by 161 · see citing works

A novel combination of K‐ras and myc amplification accompanied by point mutational activation of K‐ras in a human lung cancer.

Taya, Y., Hosogai, K., Hirohashi, S., Shimosato, Y., Tsuchiya, R., Tsuchida, N., Fushimi, M., Sekiya, T., & Nishimura, S. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02236.x · Cited by 157 · see citing works

Human cancer and cellular oncogenes

Nishimura, S., & Sekiya, T. (1987) · Biochemical Journal · doi:10.1042/bj2430313 · Cited by 153 · see citing works

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.

Sekiya, T., Fushimi, M., Hori, H., Hirohashi, S., Nishimura, S., & Sügimura, T. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4771 · Cited by 127 · see citing works

Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

Vousden, K. H., Bos, J. L., Marshall, C. J., & Phillips, D. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1222 · Cited by 127 · see citing works

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells

Lacal, J. C., Srivastava, S. K., Anderson, P. S., & Aaronson, S. A. (1986) · Cell · doi:10.1016/0092-8674(86)90270-9 · Cited by 111 · see citing works

Transgenic Mice Carrying the Mouse Mammary Tumor Virus ras Fusion Gene: Distinct Effects in Various Tissues

Tremblay, P. J., Pothier, F., Hoang, T., Tremblay, G. A., Brownstein, S., Liszauer, A., & Jolicoeur, P. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.854 · Cited by 95 · see citing works

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

Huang, M., Chida, K., Kamata, N., Nose, K., Kato, M., Homma, Y., Takenawa, T., & Kuroki, T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81311-x · Cited by 92 · see citing works

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

Lacal, J. C., Santos, E., Notario, V., Barbacid, M., Yamazaki, S., Kung, H. F., Seamans, C., McAndrew, S. J., & Crowl, R. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5305 · Cited by 88 · see citing works

Protein kinase C couples membrane excitation to acetylcholine receptor gene inactivation in chick skeletal muscle

Huang, C., Tong, J., & Schmidt, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90030-h · Cited by 87 · see citing works

Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene

Valenzuela, D., & Groffen, J. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.2.843 · Cited by 86 · see citing works

The pediatric cancer quality of life inventory-32 (PCQL-32)

Varni, J. W., Katz, E. R., Seid, M., Quiggins, D. J. L., & Friedman-Bender, A. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980315)82:6 · Cited by 217 · see citing works

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

Costa-Cabral, S., Brough, R., Konde, A., Aarts, M., Campbell, J., Marinari, E., Riffell, J. L., Bardelli, A., Torrance, C. J., Lord, C. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149099 · Cited by 77 · see citing works

Translating Genomics for Precision Cancer Medicine

Roychowdhury, S., & Chinnaiyan, A. M. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025552 · Cited by 74 · see citing works

Molecular Pathways: MicroRNAs as Cancer Therapeutics

Melo, S. A., & Kalluri, R. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2010 · Cited by 73 · see citing works

Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

Morales, C., García, M. J., Ribas, M., Miró, R., Muñoz, M., Caldas, C., & Peinado, M. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0759 · Cited by 73 · see citing works

Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice.

Fukui, M., Yamamoto, T., Kawai, S., Maruo, K., & Toyoshima, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5954 · Cited by 68 · see citing works

Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.

Manne, V., Yamazaki, S., & Kung, H. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.6953 · Cited by 66 · see citing works

The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of Kit

Berrozpe, G., Timokhina, I., Yukl, S. A., Tajima, Y., Ono, M., Zelenetz, A. D., & Besmer, P. (1999) · Blood · doi:10.1182/blood.v94.8.2658.420k23_2658_2666 · Cited by 62 · see citing works

Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells.

Pfeifer, A. M. A., Mark, G. E., Malan-Shibley, L. B., Graziano, S. L., Amstad, P., & Harris, C. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.10075 · Cited by 60 · see citing works

Inhibition of benzo[a]pyrene-induced mutagenesis by (–)-epigallocatechin gallate in the lung of rpsL transgenic mice

Muto, S., Yokoi, T., Gondo, Y., Katsuki, M., Shioyama, Y., Fujita, K.-I., & Kamataki, T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.3.421 · Cited by 56 · see citing works

Structure of the c-Ki-ras Gene in a Rat Fibrosarcoma Induced by 1,8-Dinitropyrene

Tahira, T., Hayashi, K., Ochiai, M., Tsuchida, N., Nagao, M., & Sügimura, T. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1349 · Cited by 52 · see citing works

Utilizing protein structure to identify non-random somatic mutations

Ryslik, G. A., Cheng, Y., Cheung, K.-H., Modis, Y., & Zhao, H. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-190 · Cited by 51 · see citing works

Activation of ras p21 Transforming Properties Associated with an Increase in the Release Rate of Bound Guanine Nucleotide

Lacal, J. C., & Aaronson, S. A. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4214 · Cited by 51 · see citing works

Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.

Gambke, C., Hall, A., & Moroni, C. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.879 · Cited by 47 · see citing works

Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells

Chernov, A. V., Reyes, L., Xu, Z., Gonzalez, B., Golovko, G., Peterson, S. N., Perucho, M., Fofanov, Y., & Strongin, A. Y. (2015) · Epigenetics · doi:10.1080/15592294.2015.1020000 · Cited by 46 · see citing works

Transforming Genes and Target Cells of Murine Spleen Focus-Forming Viruses

Ostertag, W., Stocking, C., Johnson, G. R., Kluge, N., Kollek, R., Franz, T., & Hess, N. K. (1987) · Advances in cancer research · doi:10.1016/s0065-230x(08)60693-4 · Cited by 45 · see citing works

Activation of a human c-K-rasoncogeoe

Yamamoto, F., & Perucho, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.23.8873 · Cited by 42 · see citing works

Organ specific expression of ras oncoproteins during growth and development of the rat

Tanaka, T., Ida, N., Shimoda, H., Waki, C., Slamon, D. J., & Cline, M. (1986) · Molecular and Cellular Biochemistry · doi:10.1007/bf00233807 · Cited by 38 · see citing works

Involvement of the RAFI locus, at band 3p25, in the 3p deletion of small‐cell lung cancer

Graziano, S. L., Pfeifer, A. M. A., Testa, J. R., Mark, G. E., Johnson, B. E., Hallinan, E. J., Pettengill, O. S., Sorenson, G. D., Tatum, A. H., Brauch, H. B., et al. (1991) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870030407 · Cited by 37 · see citing works

Oncogene Amplification During Tumorigenesis of Established Rat Fibroblasts Reversibly Transformed by Activated Human ras Oncogenes

Winter, E., & Perucho, M. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.7.2562 · Cited by 37 · see citing works

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Curatolo, A. D., Conciatori, F., Incani, U. C., Bazzichetto, C., Falcone, I., Corbo, V., D’Agosto, S. L., Eramo, A., Sette, G., Sperduti, I., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0820-5 · Cited by 36 · see citing works

Molecular staging of colorectal cancer

Thebo, J. S., Senagore, A. J., Reinhold, D. S., & Stapleton, S. R. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02236973 · Cited by 34 · see citing works

Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

Ye, X., Chan, K. C., Waters, A. M., Bess, M., Harned, A., Wei, B., Lončarek, J., Luke, B. T., Orsburn, B. C., Hollinger, B. D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13566 · Cited by 33 · see citing works

Amplification and enhanced expression of the c-Ki-ras2 protooncogene in human embryonal carcinomas.

Wang, L.-C., Vass, W. C., Gao, C., & Chang, K. S. S. (1987) · PubMed · Cited by 33 · see citing works

Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach

Kumar, S. U., Bithia, R., Kumar, D. T., Doss, C. G. P., & Zayed, H. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1830177 · Cited by 32 · see citing works

Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer

Masramon, L., Arribas, R., Tórtola, S., Perucho, M., & Peinado, M. A. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.390 · Cited by 32 · see citing works

Oncogenes and human cancer

Enrique, P. (1985) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(85)90201-8 · Cited by 31 · see citing works

Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line.

George, D. L., Glick, B. R., Trusko, S. P., & Freeman, N. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1651 · Cited by 30 · see citing works

Mechanism of activation of human ras genes cloned from a gastric adenocarcinoma and a pancreatic carcinoma cell line.

O’Hara, B., Oskarsson, M. K., Tainsky, M. A., & Blair, D. G. (1986) · PubMed · Cited by 28 · see citing works

Oncogenes and Tumor-Suppressor Genes

Lehman, T. A., Reddel, R. R., Peiifer, A. M., Spillare, E. A., Kaighn, M. E., Weston, A., Gerwin, B. I., & Harris, C. C. (1991) · Environmental Health Perspectives · doi:10.1289/ehp.9193133 · Cited by 27 · see citing works

Head perturbations during walking while viewing a head-fixed target.

Das, V. E., Zivotofsky, A. Z., DiScenna, A. O., & Leigh, R. J. (1995) · PubMed · Cited by 27 · see citing works

Ki‐ras activation and expression in transformed mouse lung cell lines

Pan, Y. H. L., Nuzum, E. O., Hanson, L. A., & Beer, D. G. (1990) · Molecular Carcinogenesis · doi:10.1002/mc.2940030508 · Cited by 27 · see citing works

Chromatin structure of the promoter region of the human c-K-ras gene

Jordano, J., & Perucho, M. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.18.7361 · Cited by 26 · see citing works

Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms

Couce, M., Bautista, D., Costa, J. C., & Carter, D. (1999) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199906000-00003 · Cited by 22 · see citing works

Growth and differentiation of normal and transformed human bronchial epithelial cells

Masui, T., Lechner, J. F., Yoakum, G. H., Willey, J. C., & Harris, C. C. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041290414 · Cited by 22 · see citing works

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

Lo, A., Holmes, K., Kamlapurkar, S., Mundt, F., Moorthi, S., Fung, I., Fereshetian, S., Watson, J., Carr, S. A., Mertins, P., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abc4520 · Cited by 21 · see citing works

Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation

Tago, K., Funakoshi‐Tago, M., Ohta, S., Kawata, H., Saitoh, H., Horie, H., Aoki‐Ohmura, C., Yamauchi, J., Tanaka, A., Matsugi, J., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12580 · Cited by 21 · see citing works

Ras2 and Ras1 Protein Phosphorylation in Saccharomyces cerevisiae

Whistler, J. L., & Rine, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18790 · Cited by 20 · see citing works

Neuroendocrine neoplasms of the lung are not associated with point mutations at codon 12 of the Ki-ras gene

Wagner, S. N., Müller, R., Boehm, J., Pütz, B., Wünsch, P. H., & Höfler, H. (1993) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899279 · Cited by 19 · see citing works

Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.

Ruı́z-Godoy, R. L. M., García-Cuellar, C. M., Ne, H. G., Bl, S., Pérez‐Cárdenas, E., Sánchez-Pérez, Y., Suárez‐Roa, M. D. L., & Meneses, A. (2006) · PubMed · Cited by 18 · see citing works

Cell type-specific expressions of c-ras gene products in the normal rat

Tanaka, T., Ida, N., Waki, C., Shimoda, H., Slamon, D. J., & Cline, M. J. (1987) · Molecular and Cellular Biochemistry · doi:10.1007/bf00231605 · Cited by 17 · see citing works

Neurospora crassa cDNA clones coding for a new member of the ras protein family

Altschuler, D. L., Muro, A. F., Schijman, A. G., Bravo-Almonacid, F. F., & Torres, H. N. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81061-r · Cited by 17 · see citing works

Mutational Spectrum of Fanconi Anemia Associated Myeloid Neoplasms

Chao, M. M., Thomay, K., Goehring, G., Włodarski, M. W., Pastor, V. M. L., Schlegelberger, B., Schindler, D., Kratz, C. P., & Niemeyer, C. M. (2017) · Klinische Pädiatrie · doi:10.1055/s-0043-117046 · Cited by 16 · see citing works

Identification of Genes That Exhibit Changes in Expression on the 8p Chromosomal Arm by the Systematic Multiplex RT-PCR (SM RT-PCR) and DNA Microarray Hybridization Methods

Yamamoto, F., & Yamamoto, M. (2008) · Gene Expression · doi:10.3727/105221608786883816 · Cited by 16 · see citing works

Quantitative comparative mutagenesis in bacteria, mammalian cells, and animal-mediated assays A convenient way of estimating genotoxic activity in vivo?

Mohn, G. R., & van Zeeland, A. A. (1985) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(85)90113-7 · Cited by 16 · see citing works

Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes

Perucho, M., & Estéban, M. (1985) · Journal of Virology · doi:10.1128/jvi.54.1.229-232.1985 · Cited by 13 · see citing works

A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

Jazieh, K., Molina, J. R., Allred, J. B., Yin, J., Reid, J. M., Goetz, M. P., Lim, V.-S., Kaufmann, S. H., & Adjei, A. A. (2018) · Investigational New Drugs · doi:10.1007/s10637-018-0662-1 · Cited by 11 · see citing works

Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors

Aoki, K., Ohnami, S., & Yoshida, T. (2004) · Humana Press eBooks · doi:10.1385/1-59259-854-4:193 · Cited by 11 · see citing works

Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis

Qi, C., Chen, Y., Zhou, Y., Huang, X., Li, G., Zeng, J., Ruan, Z., Xie, X., & Zhang, J. (2018) · Oncology Reports · doi:10.3892/or.2018.6303 · Cited by 10 · see citing works

Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient.

Yuasa, Y., Oto, M., Sato, C., Miyaki, M., Iwama∥, T., Tonomura, A., & Namba, M. (1986) · PubMed · Cited by 9 · see citing works

Malignant Giant Cell Tumor of Bone With a KRAS G12V Mutation

Donigian, S., Whiteway, S. L., Hipp, S. J., Lybeck, D., & Clark, R. O. (2021) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000002112 · Cited by 8 · see citing works

Isolation and characterization of an activated c‐H‐ras‐1 gene from a squamous‐cell lung carcinoma cell line

Kagimoto, M., Miyoshi, J., Tashiro, K., Naito, Y., Sakaki, Y., Sueishi, K., Tanaka, K., & Imamura, T. (1985) · International Journal of Cancer · doi:10.1002/ijc.2910350618 · Cited by 8 · see citing works

A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C)

Li, N., Liu, C., Zhang, W., & Rao, G. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673258913231019113814 · Cited by 7 · see citing works

Oncogenes and the Genetic Dissection of Human Cancer: Implications for Basic Research and Clinical Medicine

Boehm, T. L. J. (1985) · Progress in clinical biochemistry and medicine · doi:10.1007/978-3-642-70570-0_1 · Cited by 7 · see citing works

A Human Ki-ras Oncogene Encodes Two Transforming p21 Proteins

McCoy, M. S., & Weinberg, R. A. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.4.1326 · Cited by 7 · see citing works

Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members

Adamopoulos, P. G., Tsiakanikas, P., Boti, M. A., & Scorilas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413298 · Cited by 6 · see citing works

Modified responsiveness of v‐Ha‐ras‐transfected rat fibroblasts to growth factors and a tumor promoter

Huang, M., Kamata, N., Nose, K., & Kuroki, T. (1988) · Molecular Carcinogenesis · doi:10.1002/mc.2940010206 · Cited by 5 · see citing works

Nucleic Acid Sequence Database VI: Retroviral Oncogenes and Cellular Proto-Oncogenes

CHEN, H. R., & Barker, W. C. (1985) · DNA · doi:10.1089/dna.1985.4.171 · Cited by 5 · see citing works

DNA analysis in human disease.

Wright, A. F. (1986) · Journal of Clinical Pathology · doi:10.1136/jcp.39.12.1281 · Cited by 5 · see citing works

Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines

Khan, S. (2013) · doi:10.53846/goediss-3878 · Cited by 5 · see citing works

Basic Science Review: Retroviruses and Human Cancer: Evaluation of T-Lymphocyte Transformation by Human T-Cell Leukemia-Lymphoma Virus

Lobach, D. F., Bolognesi, D. P., & Kaufman, R. E. (1985) · Cancer Investigation · doi:10.3109/07357908509017497 · Cited by 4 · see citing works

Detection of oncogene‐related proteins with site‐directed monoclonal antibody probes

Niman, H. L. (1987) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860010105 · Cited by 4 · see citing works

Critical amino acids of p21 protein are located within β-turns: Further evaluation

Murakami, M. (1987) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(87)80076-0 · Cited by 4 · see citing works

Activation of a human c-K-rasoncogeoe

Yamamoto, F., & Perucho, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.23.8873 · Cited by 42 · see citing works

Activation of the c-K-ras oncogene in a human pancreas carcinoma

Hirai, H., Okabe, T., ANRAKU, Y., Fujisawa, M., Urabe, A., & Takaku, F. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(85)80140-6 · Cited by 47 · see citing works

Characterization of a human colon/lung carcinoma oncogene

McCoy, M. S., Toole, J. J., Cunningham, J. M., Chang, E. H., Lowy, D. R., & Weinberg, R. A. (1983) · Nature · doi:10.1038/302079a0 · Cited by 207 · see citing works

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

Guerrero, I., Villasanté, A., Corces, V. G., & Pellicer, À. (1984) · Science · doi:10.1126/science.6474169 · Cited by 175 · see citing works

Isolation and characterization of an activated c‐H‐ras‐1 gene from a squamous‐cell lung carcinoma cell line

Kagimoto, M., Miyoshi, J., Tashiro, K., Naito, Y., Sakaki, Y., Sueishi, K., Tanaka, K., & Imamura, T. (1985) · International Journal of Cancer · doi:10.1002/ijc.2910350618 · Cited by 8 · see citing works