The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes.
Open accessAbstract
Spin-labeled analogs of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been used to study phospholipid transverse diffusion and asymmetry in the human erythrocyte membrane. Ascorbate reduction was used to assess the transbilayer distribution of the labels. All three spin-labeled phospholipids initially incorporated into the outer leaflet of the membrane. On fresh erythrocytes at 5 degrees C, the phosphatidylcholine label remained mainly in the outer leaflet. In contrast, the phosphatidylserine and phosphatidylethanolamine labels underwent rapid transverse diffusion that led to their asymmetric distribution in favor of the inner leaflet. The latter effect was reversibly inhibited after ATP depletion of the erythrocytes and could be reproduced on resealed erythrocyte ghosts only if hydrolyzable Mg-ATP was included in the internal medium. It is suggested that an ATP-driven transport of amino phospholipids toward the inner leaflet could be the major cause of the phospholipid asymmetry in the erythrocyte membrane. It is also proposed that the same mechanism could explain the ATP requirement of the maintenance of the erythrocyte membrane discoid shape.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
Sheetz, M. P., & Singer, S. J. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4457 · Cited by 1,385
Op den Kamp, J. A. F. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.000403 · Cited by 1,261
Verkleij, A. J., Zwaal, R. F. A., Roelofsen, B., Comfurius, P., Kastelijn, D., & van Deenen, L. L. M. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90143-0 · Cited by 1,106
Inside-outside transitions of phospholipids in vesicle membranes
McConnell, H. M., & Kornberg, R. D. (1971) · Biochemistry · doi:10.1021/bi00783a003 · Cited by 955
The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography
Comfurius, P., & Zwaal, R. F. A. (1977) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(77)90120-5 · Cited by 563
Zwaal, R. F. A., Roelofsen, B., Comfurius, P., & van Deenen, L. L. M. (1975) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(75)90044-9 · Cited by 359
Spectrin as a stabilizer of the phospholipid asymmetry in the human erythrocyte membrane
Haest, C. W. M., Plasa, G., Kamp, D., & Deuticke, B. (1978) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(78)90004-4 · Cited by 344
The asymmetric arrangement of phospholipids in the human erythrocyte membrane
Gordesky, S. E., & Marinetti, G. V. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91509-x · Cited by 340
Preparation and properties of human erythrocyte ghosts
Schwoch, G., & Passow, H. (1973) · Molecular and Cellular Biochemistry · doi:10.1007/bf01795474 · Cited by 291
Bretscher, M. S. (1972) · Journal of Molecular Biology · doi:10.1016/s0022-2836(72)80020-2 · Cited by 291
Cited by
Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
Zwaal, R. F. A., & Schroit, A. J. (1997) · Blood · doi:10.1182/blood.v89.4.1121 · Cited by 1,340
The Distribution and Function of Phosphatidylserine in Cellular Membranes
Leventis, P. A., & Grinstein, S. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131234 · Cited by 988
Lipid traffic: floppy drives and a superhighway
Holthuis, J. C. M., & Levine, T. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1591 · Cited by 490
Lipid–protein interactions in blood coagulation
Zwaal, R. F. A., Comfurius, P., & Bevers, E. M. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00018-5 · Cited by 294
Loss of Tmem30a leads to photoreceptor degeneration
Zhang, L., Yang, Y., Li, S., Zhang, S., Zhu, X., Tai, Z., Yang, M., Liu, Y., Guo, X., Chen, B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09506-5 · Cited by 28
Metadata
- Authors
- Seigneuret, M., & Devaux, P. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-06
- Volume
- 81
- Issue
- 12
- Pages
- 3751-3755
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060759428
- Cited by
- 699
- References
- 12
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. https://app.cochat.ai/papers/10.1073/pnas.81.12.3751
- The paper
- Seigneuret, M., & Devaux, P. F. (1984). ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.12.3751
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
