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The Distribution and Function of Phosphatidylserine in Cellular Membranes
Abstract
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly distributed, PS is found preferentially in the inner leaflet of the plasma membrane and in endocytic membranes. The loss of PS asymmetry is an early indicator of apoptosis and serves as a signal to initiate blood clotting. This review discusses the determinants and functional implications of the subcellular distribution and membrane topology of PS.
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PTDSS1 encodes an enzyme that produces phosphatidylserine.
“PTDSS1, which encodes an enzyme that produces phosphatidylserine (PS) (13–15).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [14]
PS is synthesized by PTDSS1 in the ER, after which a portion is decarboxylated by PSD1 in mitochondria to form PE.
“PS is synthesized by PTDSS1 in the ER, after which a portion of PS is decarboxylated by PS decarboxylase 1 (PSD1) in mitochondria to form phosphatidylethanolamine (PE) (14).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [14]
PTDSS1 product PS synthase-1 is a major source of PS in cell membranes.
“Among the highest-scoring genes was PTDSS1, whose product, PS synthase-1, is a major source of PS in cell membranes (13, 14).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [14]
The CRISPR screen revealed a requirement for PTDSS1 for cholesterol trafficking from lysosome to ER.
“This screen revealed a requirement for PTDSS1, which encodes an enzyme that produces phosphatidylserine (PS) (13–15).”
From Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine (2020) · cites this paper as [14]
Citations
Cites
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Metadata
- Authors
- Leventis, P. A., & Grinstein, S.
- Affiliations
- Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada;,
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2010-04-01
- Volume
- 39
- Issue
- 1
- Pages
- 407-427
- ISSN
- 1936-122X
- 1936-1238
- Cited by
- 988
- References
- 3
- Language
- en
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