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Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
Open accessAbstract
Genes that regulate the development of the fruit fly Drosophila melanogaster exist as tightly linked clusters in at least two cases. These clusters, the bithorax complex (BX-C) and the Antennapedia complex (ANT-C), both contain multiple homoeotic loci: mutations in each locus cause a transformation of one part of the fly into another. Several repetitive DNA sequences, including at least one transposon, were mapped in the ANT-C. DNA from the 3' exon of Antennapedia (Antp), a homoeotic locus in the ANT-C, hybridized weakly to DNA from the 3' exon of Ultrabithorax (Ubx), a homoeotic locus in the BX-C. DNA from each of these 3' exons also hybridized weakly to DNA from the fushi tarazu locus of the ANT-C. The fushi tarazu (ftz) locus controls the number and differentiation of segments in the developing embryo. Sequence analysis of the cross-hybridizing DNA from the three loci revealed the conservation of predicted amino acid sequences derived from coding parts of the genes. This suggests that two homoeotic loci and a "segment-deficient" locus encode protein products with partially shared structures and that the three loci may be evolutionarily and functionally related.
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Citations
Cited by
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Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Macdonald, P. M., Ingham, P., & Struhl, G. (1986) · Cell · doi:10.1016/0092-8674(86)90515-5 · Cited by 375
HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.
Baumhueter, S., Mendel, D. B., Conley, P. B., Kuo, C. J., Turk, C., Graves, M. K., Edwards, C. A., Courtois, G., & Crabtree, G. R. (1990) · Genes & Development · doi:10.1101/gad.4.3.372 · Cited by 260
Metadata
- Authors
- Scott, M. P., & Weiner, A. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-07
- Volume
- 81
- Issue
- 13
- Pages
- 4115-4119
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2022893667
- Cited by
- 778
- References
- 0
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. https://app.cochat.ai/papers/10.1073/pnas.81.13.4115
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- Scott, M. P., & Weiner, A. J. (1984). Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.13.4115
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