Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box
Abstract
We report the isolation, sequence, and transcriptional behavior of the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. We show that the eve gene contains a homeo box and hence is related structurally to the pair-rule gene fushi tarazu and to homeotic selector genes. However, the eve homeo box differs significantly from those previously described and encodes a putative DNA recognition helix that would probably recognize different sequences. The eve gene resembles other pair-rule genes in showing a transient seven stripe zebra pattern during the blastoderm stage, but seven additional stripes arise soon thereafter. Together, these 14 stripes are required for the activation of coincident stripes of engrailed transcripts, leading to the subdivision of the embryo into compartmental and segmental units.
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The development of gene expression stripes in Drosophila embryonic development is driven by the expression of pair-rule genes such as even-skipped.
“One of the best-characterised examples of this is the development of gene expression “stripes” in Drosophila embryonic development, which is driven by the expression of pair-rule genes such as even-skipped (eve) [120].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [120]
Cites
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413 · see citing works
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Goto, T., Macdonald, P., & Maniatis, T. (1989) · Cell · doi:10.1016/0092-8674(89)90916-1 · Cited by 277 · see citing works
Self-citation<i>Gsh</i> ‐ <i>1</i> : A novel murine homeobox gene expressed in the central nervous system
Valerius, M. T., Li, H., Stock, J. L., Weinstein, M., Kaur, S., Singh, G., & Potter, S. S. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030306 · Cited by 107 · see citing works
Transcriptional enhancers and their communication with gene promoters
Ray-Jones, H., & Spivakov, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03903-w · Cited by 81 · see citing works
Borok, M. J., Tran, D. A., Ho, M. C. W., & Drewell, R. A. (2010) · Development · doi:10.1242/dev.036160 · Cited by 54 · see citing works
- Authors
- Macdonald, P. M., Ingham, P., & Struhl, G.
- Affiliations
- Harvard University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 47
- Issue
- 5
- Pages
- 721-734
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069462985
- Cited by
- 375
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01gm029301-13)
- National Institute of General Medical Sciences (1PO1GM29301)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- even-skipped, pair-rule genes, fushi tarazu, Drosophila segmentation, engrailed, zebra patterns, blastoderm, gene expression, compartmentalization, segmental patterning
- MeSH terms
- Animals, Base Sequence, Drosophila melanogaster, Gene Expression Regulation, Genes, Homeobox, Larva, Phenotype, RNA, Messenger
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