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5' untranslated sequences are required for the translational control of a yeast regulatory gene.
Open accessAbstract
In yeast, many genes encoding amino acid biosynthetic enzymes are subject to a common regulatory system called the general control of amino acid biosynthesis. The product of the regulatory gene GCN4 is required for an increase in transcription of general control-regulated genes when yeast are grown under amino acid-starvation conditions. In this report, we show that the expression of the GCN4 gene is regulated at the translational level: the efficiency of translation of the GCN4 mRNA is dramatically increased during growth under amino acid-starvation conditions. The complete nucleotide sequence of the GCN4 gene, presented here, reveals the existence of an unusually long 5' untranslated region in the corresponding mRNA. In vivo analysis of the effects of a deletion in this 5' leader has enabled us to define a region required for the translational regulation of the GCN4 mRNA.
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Citations
Cited by
Compilation of tRNA sequences and sequences of tRNA genes
Sprinzl, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki012 · Cited by 1,914
TRANSLATIONAL REGULATION OF GCN4 AND THE GENERAL AMINO ACID CONTROL OF YEAST
Hinnebusch, A. G. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.031805.133833 · Cited by 1,251
Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes
Sharp, P. M., Tuohy, T. M. F., & Mosurski, K. R. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.13.5125 · Cited by 1,200
Multiple upstream AUG codons mediate translational control of GCN4
Mueller, P. P., & Hinnebusch, A. G. (1986) · Cell · doi:10.1016/0092-8674(86)90384-3 · Cited by 631
Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.
Kozak, M. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.10.3438 · Cited by 555
Metadata
- Authors
- Thireos, G., Penn, M. D., & Greer, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-08
- Volume
- 81
- Issue
- 16
- Pages
- 5096-5100
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969995482
- Cited by
- 245
- References
- 0
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: 5' untranslated sequences are required for the translational control of a yeast regulatory gene. https://app.cochat.ai/papers/10.1073/pnas.81.16.5096
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- Thireos, G., Penn, M. D., & Greer, H. (1984). 5' untranslated sequences are required for the translational control of a yeast regulatory gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.16.5096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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