The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.
Open accessAbstract
Simian virus 40-based plasmids that direct the synthesis of preproinsulin during short-term transfection of COS cells have been used to probe the mechanism of reinitiation by eucaryotic ribosomes. Earlier studies from several laboratories had established that the ability of ribosomes to reinitiate translation at an internal AUG codon depends on having a terminator codon in frame with the preceding AUG triplet and upstream from the intended restart site. In the present studies, the position of the upstream terminator codon relative to the preproinsulin restart site has been systematically varied. The efficiency of reinitiation progressively improved as the intercistronic sequence was lengthened. When the upstream "minicistron" terminated 79 nucleotides before the preproinsulin start site, the synthesis of proinsulin was as efficient as if there were no upstream AUG codons. A mechanism is postulated that might account for this result, which is somewhat surprising inasmuch as bacterial ribosomes reinitiate less efficiently as the intercistronic gap is widened.
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Citations
Cites
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Self-citationCompilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
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Self-citationSV40-transformed simian cells support the replication of early SV40 mutants
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Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles
Kozak, M. (1983) · Microbiological Reviews · doi:10.1128/mmbr.47.1.1-45.1983 · Cited by 1,502
Self-citationKozak, M. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.20.5233 · Cited by 1,242
Self-citationBiochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
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Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
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Cited by
Initiation of translation in prokaryotes and eukaryotes
Kozak, M. (1999) · Gene · doi:10.1016/s0378-1119(99)00210-3 · Cited by 1,364
Self-citationCalvo, S. E., Pagliarini, D. J., & Mootha, V. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810916106 · Cited by 914
The Scanning Mechanism of Eukaryotic Translation Initiation
Hinnebusch, A. G. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035802 · Cited by 798
Upstream Open Reading Frames as Regulators of mRNA Translation
Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736
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Metadata
- Authors
- Kozak, M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1987-10
- Volume
- 7
- Issue
- 10
- Pages
- 3438-3445
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2099390806
- Cited by
- 555
- References
- 55
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
