The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
Open accessAbstract
The mutagenicity of O6-methylguanine (O6MeGua), a chemical carcinogen-DNA adduct, has been studied in vivo by using a single-stranded M13mp8 genome in which a single O6MeGua residue was positioned in the unique recognition site for the restriction endonuclease Pst I. Transformation of Escherichia coli MM294A cells with this vector gave progeny phage, of which 0.4% were mutated in their Pst I site. In a separate experiment, cellular levels of O6MeGua-DNA methyltransferase (an O6MeGua-repair protein) were depleted by treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) prior to viral DNA uptake. In these cells, the mutation frequency due to O6MeGua increased with increasing MNNG dose (the highest mutation frequency observed was 20%). DNA sequence analysis of 60 mutant genomes revealed that O6MeGua induced exclusively G-to-A transitions.
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Cites
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Cited by
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
Biochemical Basis of DNA Replication Fidelity
Goodman, M. F., Creighton, S., Bloom, L. B., Petruska, J., & Kunkel, T. A. (1993) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239309086792 · Cited by 446
Boiteux, S., O'Connor, T. R., & Laval, J. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02629.x · Cited by 290
Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens
Seo, K.-Y., Jelinsky, S. A., & Loechler, E. L. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00047-8 · Cited by 126
Self-citationGuan, X., Madabushi, A., Chang, D.-Y., Fitzgerald, M. E., Shi, G., Drohat, A. C., & Lu, A.-L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm678 · Cited by 65
Metadata
- Authors
- Loechler, E. L., Green, C. L., & Essigmann, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-10
- Volume
- 81
- Issue
- 20
- Pages
- 6271-6275
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026195203
- Cited by
- 444
- References
- 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. https://app.cochat.ai/papers/10.1073/pnas.81.20.6271
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- Loechler, E. L., Green, C. L., & Essigmann, J. M. (1984). In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.20.6271
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
