Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

Seo, Kwang-Young; Jelinsky, Scott A.; Loechler, Edward L.

doi:10.1016/s1383-5742(00)00047-8

Cited by 126Carcinogens and Genotoxicity AssessmentDNA Repair MechanismsDNA and Nucleic Acid Chemistry

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

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Seo, Kwang-Young, Jelinsky, Scott A., Loechler, Edward L.·2000·Mutation Research/Reviews in Mutation Research

DOI 10.1016/s1383-5742(00)00047-8

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Abstract

Carcinogens are generally mutagens, which is understandable given that tumor cells grow uncontrollably because they have mutations in critical genes involved in growth control. Carcinogens often induce a complex pattern of mutations (e.g., GC-->TA, GC-->AT, etc.). These mutations are thought to be initiated when a DNA polymerase encounters a carcinogen-DNA adduct during replication. In principle, mutational complexity could be due to either a collection of different adducts each inducing a single kind of mutation (Hypothesis 1a), or a single adduct inducing different kinds of mutations (Hypothesis 1b). Examples of each are discussed. Regarding Hypothesis 1b, structural factors (e.g., DNA sequence context) and biological factors (e.g., differing DNA polymerases) that can affect the pattern of adduct mutagenesis are discussed. This raises the question: how do structural and biological factors influence the pattern of adduct mutagenesis. For structural factors, three possibilities are considered: (Hypothesis 2a) a single conformation of an adduct giving rise to multiple mutations -- dNTP insertion by DNA polymerase being influenced by (e.g.) the surrounding DNA sequence context; (Hypothesis 2b) a variation on this ("dislocation mutagenesis"); or (Hypothesis 2c) a single adduct adopting multiple conformations, each capable of giving a different pattern of mutations. Hypotheses 2a, 2b and 2c can each in principle rationalize many mutational results, including how the pattern of adduct mutagenesis might be influenced by factors, such as DNA sequence context. Five lines of evidence are discussed suggesting that Hypothesis 2c can be correct for base substitution mutagenesis. For example, previous work from our laboratory was interpreted to indicate that [+ta]-B[a]P-N(2)-dG in a 5'-CGG sequence context (G115) could be trapped in a conformation giving predominantly G-->T mutations, but heating caused the adduct to equilibrate to its thermodynamic mixture of conformations, leading to a decrease in the fraction of G-->T mutations. New work is described suggesting that [+ta]-B[a]P-N(2)-dG at G115 can also be trapped predominantly in the G-->A mutational conformation, from which equilibration can also occur, leading to an increase in the fraction of G-->T mutations. Evidence is also presented that the fraction of G-->T mutations is higher when [+ta]-B[a]P-N(2)-dG at G115 is in ss-DNA ( approximately 89%) vs. ds-DNA ( approximately 66%), a finding that can be rationalized if the mixture of adduct conformations is different in ss- and ds-DNA. In summary, the factors affecting adduct mutagenesis are reviewed and five lines of evidence that support one hypothesis (2c: adduct conformational complexity can cause adduct mutational complexity) are discussed.

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A Comprehensive Survey of Ras Mutations in Cancer
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The current state of the art and future trends in RAS-targeted cancer therapies
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Authors: Seo, K.-Y., Jelinsky, S. A., & Loechler, E. L.
Affiliations: Boston University (US)
Corresponding author: Loechler, Edward L.
ORCID: Jelinsky, Scott A.
Venue: Mutation Research/Reviews in Mutation Research
Publisher: Elsevier BV
Published: 2000-10
Volume: 463
Issue: 3
Pages: 215-246
ISSN: 1383-5742 (ISSN-L)
DOI: 10.1016/s1383-5742(00)00047-8
OpenAlex: W2091661023
Cited by: 126
References: 199
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI: 3.36
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 363 d)
Locations: Mutation Research/Reviews in Mutation Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (1s10rr011397-01)
National Institute of Environmental Health Sciences (ES 03775, R01ES003775)
National Center for Research Resources (RR11397)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: DNA adducts, chemical carcinogens, DNA sequence context, DNA polymerase, benzo[a]pyrene, mutational hotspots, DNA replication errors
MeSH terms: Animals, Benzo(a)pyrene, Carcinogens, DNA, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Eukaryotic Cells, Humans, Models, Biological, Mutagens, Nucleic Acid Conformation, Prokaryotic Cells, Structure-Activity Relationship, Temperature, 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, Mutagenesis, Point Mutation, DNA Adducts

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Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

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