Cited by 117Phosphodiesterase function and regulationReceptor Mechanisms and SignalingNitric Oxide and Endothelin Effects

Effects of Cyclic GMP on Smooth Muscle Relaxation

Warner, Timothy D., Mitchell, Jane A., Sheng, Hong, Murad, Ferid·1994·Advances in Pharmacology

Abstract

Cyclic GMP levels within smooth muscle are affected then by a number of different pathways. Physiologically NO and ANF are probably the two most important regulators for smooth muscle function, but a variety of other mediators and pharmacological agents may also influence this system. Because of the important role that cyclic GMP plays in the control of smooth muscle tone, which clearly includes vascular smooth muscle, it is now and will continue to be in the future an important physiological and biochemical target for research and a pharmacological target for therapeutic agents.

Integrity signals

Registry

Crossref · 10.1016/s1054-3589(08)60054-x

Cites

172 of 172 references verified0 citation errors · 0 not checkable

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This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The molybdopterin cofactor of sulfite oxidase catalyzes nitrite reduction to produce NO.

    “Like XO and AO, the molybdopterin cofactor of sulfite oxidase is able to catalyze nitrite reduction to produce NO (Table 4) (990).”
  • All four mammalian molybdenum-containing enzymes (XO, AO, sulfite oxidase, and mARC) are able to reduce nitrite at different intrinsic rates.

    “Subsequently, several reports have shown that all mammalian Mo-containing enzymes [XO, aldehyde oxidase (AO), sulfite oxidase, and the mitochondrial amidoxime-reducing component (mARC)] are able to reduce nitrite at different intrinsic rates (Table 4) (575, 880, 990).”

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Authors
Warner, T. D., Mitchell, J. A., Sheng, H., & Murad, F.
Affiliations
  • St Bartholomew's Hospital (GB)
  • University of California, Los Angeles (US)
Venue
Advances in Pharmacology
Publisher
Elsevier
Published
1994
Volume
26
Pages
171-194
ISSN
1054-3589 (ISSN-L)
OpenAlex
W1437168237
Cited by
117
References
176
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
3.34
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
cyclic GMP, smooth muscle relaxation, guanylate cyclase, nitric oxide, atrial natriuretic peptide, smooth muscle tone, second messengers
MeSH terms
Animals, Cyclic GMP, Guanylate Cyclase, Humans, Isoenzymes, Muscle Relaxation, Muscle, Smooth

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