Cyclic guanosine monophosphate as a mediator of vasodilation.
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Nitric oxide is an important signaling molecule involved in vasodilation and neurotransmission via activation of soluble guanylate cyclase and generation of the second messenger cGMP.
“Nitric oxide (•NO) is an important signaling molecule involved in vasodilation and neurotransmission via activation of soluble guanylate cyclase and generation of the second messenger cGMP [69].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [69]
The paper’s Figure 1 caption states that nitric oxide derived from nitrovasodilators activates soluble guanylate cyclase, increases cyclic GMP synthesis, and leads to vascular relaxation. The passages in our copy do not address nitric oxide’s role in neurotransmission, so that part of the claim is unsupported. (LLM, conf=0.88)
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Research works printed but not linked: 14
- Mittal, C. K., and F. Murad. 1982. In Handbook of Experimental Pharmacology. Vol. 58-1. J. A. Nathanson and J. W. Kebabian, editors. Springer-Verlag, Berlin. 225-260.
- Arnold, W. P., C. K. Mittal, S. Katsuki, and F. Murad. 1977. Proc. Natl. Acad. Sci. USA. 74:3203-3207.
- Mittal, C. K., and F. Murad. 1977. Proc. Natl. Acad. Sci. USA. 74:4360-4364.
- Field, M., L. H. Graf, W. J. Laird, and P. L. Smith. 1978. Proc. Natl. Acad. Sci. USA. 75:2800-2804.
- Winquist, R. J., E. P. Faison, S. A. Waldman, K. Schwartz, F. Murad, and R. M. Rapoport. 1984. Proc. Natl. Acad. Sci. USA. 81: 7661-7664.
- Stryer, L. 1986. Annual Review ofNeuroscience 9: In press.
- Rapoport, R. M., M. Draznin, and F. Murad. 1982. Proc. Natl. Acad. Sci. USA. 79:6470-6474.
- Rapoport, R. M., M. B. Draznin, and F. Murad. 1983. Trans. Assoc. Am. Physicians. 96:19-30.
- Rapoport, R. M., S. A. Waldman, R. Ginsburg, C. Molina, and F. Murad. 1986. Eur. J. Pharmacol. In press.
- DeBold, A. 1982. Proc. Soc. Exp. Biol. Med. 170:133-138.
- Leitman, D. C., S. A. Waldman, R. M. Rapoport, and F. Murad. 1985. Trans. Assoc. Am. Physicians. In press.
- Kuno, T., J. W. Andresen, Y. Kamisaki, S. A. Waldman, L. Y. Chang, S. Saheki, D. C. Leitman, M. Nakane, and F. Murad. 1986. J. Biol. Chem. In press.
- Leitman, D. C., J. W. Andresen, T. Kuno, Y. Kamisaki, J. W. Chang, and F. Murad. J. Biol. Chem. In press.
- Waldman, S. A., R. M. Rapoport, R. Ginsburg, and F. Murad. 1986. Biochem. Pharmacol. In press. Cyclic Guanosine Monophosphate and Vasodilation 5
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Self-citationProtein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
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“Nitric oxide (NO) is an important signaling molecule involved in vasodilation and neurotransmission via activation of soluble guanylate cyclase and generation of the second messenger cGMP [69].”
BackgroundMyers, R. H., Schaefer, E. J., Wilson, P. W. F., D'Agostino, R., Ordovas, J. M., Espino, A., Au, R., White, R. F., Knoefel, J. E., Cobb, J. L., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.673 · Cited by 346 · see citing works
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Cell signaling mediated by nitrated cyclic guanine nucleotide
Akaike, T., Fujii, S., Sawa, T., & Ihara, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.06.006 · Cited by 49 · see citing works
- Authors
- Murad, F.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Murad, F
- Venue
- Journal of Clinical Investigation
- Published
- 1986-07-01
- Volume
- 78
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC329522
- OpenAlex
- W2065399599
- Cited by
- 799
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 13 · 2014: 18 · 2013: 16 · 2012: 14
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am030787-05)
- National Heart, Lung, and Blood Institute (HL-28474)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- cyclic GMP, vasodilation, smooth muscle relaxation, nitric oxide signaling
- MeSH terms
- Azides, Endothelium, Enzyme Activation, Cyclic GMP, Guanosine Triphosphate, Guanylate Cyclase, Half-Life, Hydrogen-Ion Concentration, Isoenzymes, Kinetics, Models, Biological, Molecular Weight, Muscle Relaxation, Muscle, Smooth, Vascular, Nitric Oxide, Nitroprusside, Oxygen, Protein Kinases, Vasodilation, Vasodilator Agents, GTP Phosphohydrolases
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