The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus.
Open accessAbstract
We have developed a continuous human T-cell line (A3.01) for the study of acquired immunodeficiency syndrome (AIDS)-associated retrovirus that mimics normal peripheral blood lymphocytes in susceptibility to viral cytopathic effect without the need for cell activation or conditioned medium. Following infection, substantial quantities of virus are produced during a 3- to 5-day period; the associated killing of cells can be monitored in a microtiter assay as a function of virus input. Southern blot hybridization of infected cellular DNAs indicated that no gross alteration occurred in the restriction maps of the proviral DNA during the transfer of virus to and its passage in A3.01 cells. This cell system offers an alternative to other AIDS retrovirus cell systems because it permits the monitoring of viral cytopathic effects.
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Cites
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Cited by
Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
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Self-citationDirect Polyclonal Activation of Human B Lymphocytes by the Acquired Immune Deficiency Syndrome Virus
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Metadata
- Authors
- Folks, T., Benn, S., Rabson, A., Theodore, T., Hoggan, M. D., Martin, M., Lightfoote, M., & Sell, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-07
- Volume
- 82
- Issue
- 13
- Pages
- 4539-4543
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965528983
- Cited by
- 318
- References
- 20
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. https://app.cochat.ai/papers/10.1073/pnas.82.13.4539
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- Folks, T., Benn, S., Rabson, A., Theodore, T., Hoggan, M. D., Martin, M., Lightfoote, M., & Sell, K. (1985). Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.13.4539
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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