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Variation among human 28S ribosomal RNA genes.
Open accessAbstract
We report the complete 5025-base sequence of the human 28S rRNA gene. Variability within the species has been demonstrated by sequencing a variable region from six separately cloned genes. This region is one of three large subunit rRNA regions that show extreme sequence and size variation among species. The interspecies differences suggest species-specific functions for these sections, while the intraspecies heterogeneity indicates differences among ribosomes. Comparison of the human gene with a partial sequence from the chimpanzee 28S gene yields divergence rates for the two species: 0.8% for conserved regions of the gene and 3.7% for a variable region. The rapid divergence rates of variable regions in the ribosomal gene may permit answers to the question of time of separation of closely related species.
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Cites
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Cited by
Ribosomal DNA: Molecular Evolution and Phylogenetic Inference
Hillis, D. M., & Dixon, M. T. (1991) · The Quarterly Review of Biology · doi:10.1086/417338 · Cited by 2,573
Wong, A. J., Bigner, S. H., Bigner, D. D., Kinzler, K. W., Hamilton, S. R., & Vogelstein, B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.19.6899 · Cited by 849
The Numerous Modified Nucleotides in Eukaryotic Ribosomal RNA
Maden, B. E. H. (1990) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60629-7 · Cited by 379
Estrogen Induces Insulin—Like Growth Factor—I Expression in the Rat Uterus
Murphy, L. J., Murphy, L. C., & Friesen, H. G. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-7-445 · Cited by 349
Nunn, G. B., Theisen, B. F., Christensen, B., & Arctander, P. (1996) · Journal of Molecular Evolution · doi:10.1007/bf02198847 · Cited by 306
Metadata
- Authors
- Gonzalez, I. L., Gorski, J. L., Campen, T. J., Dorney, D. J., Erickson, J. M., Sylvester, J. E., & Schmickel, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-11
- Volume
- 82
- Issue
- 22
- Pages
- 7666-7670
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989119084
- Cited by
- 288
- References
- 1
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Gonzalez, I. L., Gorski, J. L., Campen, T. J., Dorney, D. J., Erickson, J. M., Sylvester, J. E., & Schmickel, R. D. (1985). Variation among human 28S ribosomal RNA genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.22.7666
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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