The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Estrogen Induces Insulin—Like Growth Factor—I Expression in the Rat Uterus
Abstract
The inability to convincingly demonstrate a mitogenic effect of estrogen on isolated uterine cells in culture suggests that autocrine or paracrine growth factors may be important in the estrogen-induced uterine proliferative response. Here we report that uterine expression of insulin-like growth factor-I (IGF-I), an important mediator of GH action, is increased after 17 beta-estradiol (5 micrograms/100 g bw, ip) administration to ovariectomized prepubertal rats. An increase in uterine IGF-I mRNA abundance, approximately 14-fold above untreated controls, was apparent 6 h after estrogen administration and the level achieved exceeded that seen in the uterus from intact mature rats during diestrus. In contrast to the increase in IGF-I expression in the uterus, no significant change in serum IGF-I concentration or hepatic or renal IGF-I mRNA abundance was demonstrable after 17 beta-estradiol injection of ovariectomized prepubertal rats. The increase in uterine IGF-I expression, was similar in both pituitary-intact and hypophysectomized, ovariectomized rats. We believe this is the first report of induction of IGF-I expression by estrogen in vivo. As such, the finding expands the role and significance of IGF-I as a mediator of growth beyond that related to GH.
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Cites
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DAUGHADAY, W. H., MARIZ, I. K., & BLETHEN, S. L. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-4-781 · Cited by 738
Insulin-like growth factor I stimulates growth in hypophysectomized rats
Schoenle, E., Zapf, J., Humbel, R. E., & Froesch, E. R. (1982) · Nature · doi:10.1038/296252a0 · Cited by 596
Variation among human 28S ribosomal RNA genes.
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Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth
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MURPHY, L. J., BELL, G. I., LYNN DUCKWORTH, M., & FRIESEN, H. G. (1987) · Endocrinology · doi:10.1210/endo-121-2-684 · Cited by 241
Self-citationDifferential Response of Individual Uterine Cell Types from Immature Rats Treated with Estradiol*
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Cited by
Nelson, K. G., Takahashi, T., Bossert, N. L., Walmer, D. K., & McLachlan, J. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.21 · Cited by 379
ERNST, M., HEATH, J. K., & RODAN, G. A. (1989) · Endocrinology · doi:10.1210/endo-125-2-825 · Cited by 364
Steinmetz, R. (1998) · Endocrinology · doi:10.1210/en.139.6.2741 · Cited by 329
Sex steroidal regulation of uterine leiomyoma growth and apoptosis
Maruo, T. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh019 · Cited by 294
Human Endometrium: An Active Site of Cytokine Production and Action*
TABIBZADEH, S. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-3-272 · Cited by 274
Metadata
- Authors
- Murphy, L. J., Murphy, L. C., & Friesen, H. G.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1987-07
- Volume
- 1
- Issue
- 7
- Pages
- 445-450
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2120497689
- Cited by
- 349
- References
- 15
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murphy, L. J., Murphy, L. C., & Friesen, H. G. (1987). Estrogen Induces Insulin—Like Growth Factor—I Expression in the Rat Uterus. Molecular Endocrinology. https://doi.org/10.1210/mend-1-7-445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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