The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cloning and expression of cDNA for rat heme oxygenase.
Open accessAbstract
Two cDNA clones for rat heme oxygenase have been isolated from a rat spleen cDNA library in lambda gt11 by immunological screening using a specific polyclonal antibody. One of these clones has an insert of 1530 nucleotides that contains the entire protein-coding region. To confirm that the isolated cDNA encodes heme oxygenase, we transfected monkey kidney cells (COS-7) with the cDNA carried in a simian virus 40 vector. The heme oxygenase was highly expressed in endoplasmic reticulum of transfected cells. The nucleotide sequence of the cloned cDNA was determined and the primary structure of heme oxygenase was deduced. Heme oxygenase is composed of 289 amino acids and has one hydrophobic segment at its carboxyl terminus, which is probably important for the insertion of heme oxygenase into endoplasmic reticulum. The cloned cDNA was used to analyze the induction of heme oxygenase in rat liver by treatment with CoCl2 or with hemin. RNA blot analysis showed that both CoCl2 and hemin increased the amount of hybridizable mRNA, suggesting that these substances may act at the transcriptional level to increase the amount of heme oxygenase.
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Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
Banerji, J., Rusconi, S., & Schaffner, W. (1981) · Cell · doi:10.1016/0092-8674(81)90413-x · Cited by 1,724
Hemin enhances the differentiation of mouse 3T3 cells to adipocytes
Chen, J.-J., & London, I. M. (1981) · Cell · doi:10.1016/0092-8674(81)90039-8 · Cited by 112
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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Reduced stress defense in heme oxygenase 1-deficient cells
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10925 · Cited by 1,291
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Motterlini, R., Foresti, R., Bassi, R., & Green, C. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00294-x · Cited by 846
Metadata
- Authors
- Shibahara, S., Müller, R., Taguchi, H., & Yoshida, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-12
- Volume
- 82
- Issue
- 23
- Pages
- 7865-7869
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988787425
- Cited by
- 452
- References
- 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Shibahara, S., Müller, R., Taguchi, H., & Yoshida, T. (1985). Cloning and expression of cDNA for rat heme oxygenase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.23.7865
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