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GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures.
Open accessAbstract
GABAB receptors are a subclass of receptors for gamma-amino-n-butyric acid (GABA) that are also activated by the antispastic drug beta-p-chlorophenyl-GABA (baclofen). One effect of baclofen is to inhibit excitatory transmission from CA3 to CA1 hippocampal pyramidal cells. To identify the ionic mechanism of GABAB-receptor-mediated depression, we have studied the effect of baclofen and GABA on ionic currents in voltage-clamped CA3 pyramidal cell somata in rat hippocampal slice cultures. Baclofen (10 microM) induced an inwardly rectifying outward current that reversed at -74 +/- 4.3 mV (mean +/- SD). This appeared to be a K+ current since (i) its reversal potential showed the expected shift when extracellular K+ concentration was changed and (ii) it was blocked by external Ba2+ or internal Cs+. The action of baclofen was closely imitated by GABA after the GABAA-mediated Cl- current had been abolished with pitrazepin (10 microM); under these conditions, GABA (100 microM) also produced an inwardly rectifying, Ba2+-sensitive current with a reversal potential identical to that of the baclofen-induced current. When outward currents were blocked with internal Cs+, the residual inward voltage-dependent Ca2+ current was not changed by baclofen. It is concluded that the primary effect of GABAB-receptor activation in these neurones is to increase K+ permeability rather than to reduce Ca2+ permeability.
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Citations
Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
North, R. A., Williams, J. T., Surprenant, A., & Christie, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5487 · Cited by 618
Connors, B. W., Malenka, R. C., & Silva, L. R. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017390 · Cited by 522
GABA Spillover Activates Postsynaptic GABAB Receptors to Control Rhythmic Hippocampal Activity
Scanziani, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)81069-7 · Cited by 385
Metadata
- Authors
- Gähwiler, B. H., & Brown, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-03
- Volume
- 82
- Issue
- 5
- Pages
- 1558-1562
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049230063
- Cited by
- 476
- References
- 0
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Gähwiler, B. H., & Brown, D. A. (1985). GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.5.1558
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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