The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.
Open accessAbstract
Influenza A virus-specific cytotoxic T lymphocytes (CTL) capable of lysing cells infected with any influenza A virus ("cross-reactive CTL") constitute a major portion of the host CTL response to influenza. The viral nucleoprotein (NP), a major internal virion structural protein, has been implicated as a possible target antigen for cross-reactive CTL. To directly examine CTL recognition of NP, a vaccinia virus recombinant containing a DNA copy of an influenza A virus NP gene was constructed. We found that murine cells infected with this virus were efficiently lysed in a major histocompatibility complex-restricted manner by cross-reactive CTL populations obtained by immunization with a variety of influenza A virus subtypes. In addition, the recombinant vaccinia virus containing the PR8 NP gene was able to both stimulate and prime for a vigorous secondary cross-reactive CTL response. Significantly, splenocytes from mice primed by inoculation with the recombinant vaccinia virus containing the PR8 NP gene could be stimulated by influenza A viruses of all three major human subtypes. Finally, unlabeled target competition experiments suggest that NP is a major, but not the sole, viral target antigen recognized by cross-reactive CTL.
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Cites
Cytotoxic T-Cell Immunity to Influenza
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Cited by
Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
Ulmer, J. B., Donnelly, J. J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. J., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318
Cellular immune correlates of protection against symptomatic pandemic influenza
Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J. J., & Lalvani, A. (2013) · Nature Medicine · doi:10.1038/nm.3350 · Cited by 862
Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection
Butz, E. A., & Bevan, M. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80469-0 · Cited by 769
Ecological and immunological determinants of influenza evolution.
Ferguson, N. M., Galvani, A. P., & Bush, R. M. (2003) · Nature · doi:10.1038/nature01509 · Cited by 746
Cytotoxic T cells recognize fragments of the influenza nucleoprotein
Townsend, A. R. M., Gotch, F. M., & Davey, J. (1985) · Cell · doi:10.1016/0092-8674(85)90103-5 · Cited by 668
Metadata
- Authors
- Yewdell, J. W., Bennink, J. R., Smith, G. L., & Moss, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-03
- Volume
- 82
- Issue
- 6
- Pages
- 1785-1789
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989938774
- Cited by
- 521
- References
- 14
- FWCI
- 35.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes. https://app.cochat.ai/papers/10.1073/pnas.82.6.1785
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- Yewdell, J. W., Bennink, J. R., Smith, G. L., & Moss, B. (1985). Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.6.1785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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