Cited by 292Protein Kinase Regulation and GTPase SignalingSignaling Pathways in DiseaseNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

Open access

Lai, Y, Nairn, A C, Greengard, P·1986·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.83.12.4253PMC PMC323710

Open this paper in CoChat — free account

Abstract

Ca2+/calmodulin-dependent protein kinase II contains two subunits, alpha (Mr 50,000) and beta (Mr 60,000/58,000), both of which undergo Ca2+/calmodulin-dependent autophosphorylation. In the present study, we have studied the mechanism of this autophosphorylation reaction and its effect on the activity of the enzyme. Both subunits are autophosphorylated through an intramolecular mechanism. Using synapsin I as substrate, Ca2+/calmodulin-dependent protein kinase II, in its unphosphorylated form, was totally dependent on Ca2+ and calmodulin for its activity. Preincubation of the enzyme with Ca2+, calmodulin, and ATP, under conditions where autophosphorylation of both subunits occurred, converted the enzyme to one that was only partially dependent on Ca2+ and calmodulin for its activity. No change in the total activity, measured in the presence of Ca2+ and calmodulin, was observed. The nonhydrolyzable ATP analog adenosine 5'-[beta, gamma-imido] triphosphate did not substitute for ATP in the preincubation. Moreover, dephosphorylation of autophosphorylated Ca2+/calmodulin-dependent protein kinase II with protein phosphatase 2A resulted in an enzyme that was again totally dependent on Ca2+ and calmodulin for its activity. We propose that autophosphorylation and dephosphorylation reversibly regulate the Ca2+ and calmodulin requirement of Ca2+/calmodulin-dependent protein kinase II.

Integrity signals

Registry

Crossref · 10.1073/pnas.83.12.4253

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A simplification of the protein assay method of Lowry et al. which is more generally applicable
Peterson, G. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90043-4 · Cited by 8,531
Calmodulin Plays a Pivotal Role in Cellular Regulation
Cheung, W. Y. (1980) · Science · doi:10.1126/science.6243188 · Cited by 2,434
Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch
Miller, S. (1986) · Cell · doi:10.1016/0092-8674(86)90008-5 · Cited by 864
Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.
Llinas, R. H., McGuinness, T. L., Leonard, C. S., Sugimori, M., & Greengard, P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.3035 · Cited by 641
Self-citation
PROTEIN KINASES IN THE BRAIN
Naira, A. C., Hemmings, H. C., & Greengard, P. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004435 · Cited by 551
Self-citation
Phosphorylation activates the insulin receptor tyrosine protein kinase.
Rosen, O. M., Herrera, R., Olowe, Y., Petruzzelli, L., & Cobb, M. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3237 · Cited by 545
Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.
Bennett, M. K., Erondu, N. E., & Kennedy, M. B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44239-6 · Cited by 481
Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.
Ueda, T., & Greengard, P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40170-0 · Cited by 407
Self-citation
Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins.
Goldenring, J. R., Gonzalez, B. I., McGuire, J. S., & DeLorenzo, R. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44223-2 · Cited by 339
Distinct forebrain and cerebellar isozymes of type II Ca2+/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction.
Miller, S. G., & Kennedy, M. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39454-1 · Cited by 304

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 101–200 of 292

Applications of quantitative measurements for assessing glutamate neurotoxicity.
Finkbeiner, S. M., & Stevens, C. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4071 · Cited by 80
Calcium‐dependent serine phosphorylation of synaptophysin
Rubenstein, J. L., Greengard, P., & Czernik, A. J. (1993) · Synapse · doi:10.1002/syn.890130207 · Cited by 79
Self-citation
Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
Coppini, R., Ferrantini, C., Mugelli, A., Poggesi, C., & Cerbai, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01391 · Cited by 78
Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites.
Piomelli, D., Wang, J. K., Sihra, T. S., Nairn, A. C., Czernik, A. J., & Greengard, P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8550 · Cited by 78
Self-citation
Inactivation and Self-association of Ca /Calmodulin-dependent Protein Kinase II during Autophosphorylation
Hudmon, A., Aronowski, J., Kolb, S. J., & Waxham, M. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8800 · Cited by 76
Autophosphorylation of the type II calmodulin-dependent protein kinase is essential for formation of a proteolytic fragment with catalytic activity. Implications for long-term synaptic potentiation
Kwiatkowski, A. P., & King, M. M. (1989) · Biochemistry · doi:10.1021/bi00439a010 · Cited by 76
A structural mechanism for maintaining the ‘on‐state’ of the CaMKII memory switch in the post‐synaptic density
Mullasseril, P., Döṣemeci, A., Lisman, J. E., & Griffith, L. C. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04744.x · Cited by 75
Chemical Quenched Flow Kinetic Studies Indicate an Intraholoenzyme Autophosphorylation Mechanism for Ca2+/Calmodulin-dependent Protein Kinase II
Bradshaw, J. M., Hudmon, A., & Schulman, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202154200 · Cited by 78
A novel Ca2+-dependent protein kinase from Paramecium tetraurelia.
Gundersen, R. E., & Nelson, D. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61236-0 · Cited by 72
Regulation and role of brain calcium/calmodulin-dependent protein kinase II.
Colbran, R. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90080-b · Cited by 83
Autophosphorylation restrains the apoptotic activity of DRP‐1 kinase by controlling dimerization and calmodulin binding
Shani, G., Henis‐Korenblit, S., Jona, G., Gileadi, O., Eisenstein, M., Ziv, T., Admon, A., & Kimchi, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.1099 · Cited by 71
Stabilization of Calmodulin-dependent Protein Kinase II through the Autoinhibitory Domain (*)
Ishida, A., & Fujisawa, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2163 · Cited by 77
Aberrant Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity Is Associated with Abnormal Dendritic Spine Morphology in theATRXMutant Mouse Brain
Shioda, N., Beppu, H., Fukuda, T., Li, E., Kitajima, I., & Fukunaga, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4816-10.2011 · Cited by 69
Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum
Marshall, C. B., Nishikawa, T., Osawa, M., Stathopulos, P. B., & Ikura, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.106 · Cited by 64
Mediation by Intracellular Calcium-Dependent Signals of Hypoxic Hyperpolarization in Rat Hippocampal CA1 Neurons In Vitro
Yamamoto, S., Tanaka, E., & Higashi, H. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.1.386 · Cited by 67
The role of autophosphorylation in activation of the type II calmodulin-dependent protein kinase.
Kwiatkowski, A. P., Shell, D. J., & King, M. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68667-3 · Cited by 67
A Biochemical Blueprint for Long-Term MemoryPreprint
Roberson, E. D., & Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.4.381 · Cited by 67
Localization of synapsin I at the frog neuromuscular junction
Valtorta, F., Villa, A., Jahn, R., Camilli, P. V. D., Greengard, P., & Ceccarelli, B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90353-3 · Cited by 66
Self-citation
Regulation of type-II calmodulin kinase: functional implications.
Bronstein, J., Farber, D., & Wasterlain, C. (1993) · Brain research. Brain research reviews · doi:10.1016/0165-0173(93)90011-n · Cited by 72
Developmental Regulation of Potassium Channels and the Impact on Neuronal Differentiation
Ribera, A. B., & Spitzer, N. C. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3328-3_1 · Cited by 65
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II
Yao, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27918 · Cited by 63
Structure and Regulation of Type II Calcium/Calmodulin-dependent Protein Kinase in Central Nervous System NeuronsPreprint
Kennedy, M. B., Bennett, M. K., Bulleit, R. F., Erondu, N., Jennings, V., Miller, S. G., Molloy, S. S., Patton, B. L., & Schenker, L. J. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.013 · Cited by 63
Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase Gr.
Sahyoun, N. E., McDonald, O. B., Farrell, F. X., & Lapetina, E. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2643 · Cited by 60
Mutagenesis of Thr-286 in monomeric Ca2+/calmodulin-dependent protein kinase II eliminates Ca2+/calmodulin-independent activity.
Waxham, M. N., Aronowski, J. A., Westgate, S. A., & Kelly, P. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1273 · Cited by 60
CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State
Thornquist, S. C., Langer, K., Zhang, S. X., Rogulja, D., & Crickmore, M. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.018 · Cited by 56
trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway
Hirata, Y., Takahashi, M., Kudoh, Y., Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.771519 · Cited by 60
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Bhattacharyya, M., Lee, Y. K., Muratcioglu, S., Qiu, B., Nyayapati, P., Schulman, H., Groves, J. T., & Kuriyan, J. (2020) · eLife · doi:10.7554/elife.53670 · Cited by 58
Potassium ion stimulation triggers protein translation in synaptoneurosomal polyribosomes
Weiler, I. J., & Greenough, W. T. (1991) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(91)90060-2 · Cited by 58
Activation of multifunctional Ca2+/calmodulin-dependent protein kinase in GH3 cells
Jefferson, A. B., Travis, S. M., & Schulman, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52320-6 · Cited by 58
Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology.
Ishida, A., Shigeri, Y., Taniguchi, T., & Kameshita, I. (2003) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2003.09.003 · Cited by 52
Serum and growth factors rapidly elicit phosphorylation of the Ca2+/calmodulin-dependent protein kinase II in intact quiescent rat 3Y1 cells.
Ohta, Y., Ohba, T., Fukunaga, K., & Miyamoto, E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37992-4 · Cited by 57
Calcium/Calmodulin–Dependent Protein Kinase II in Cerebrovascular Diseases
Zhang, X., Connelly, J. A., Levitan, E. S., Sun, D., & Wang, Q. J. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00901-9 · Cited by 55
Computational and site‐specific mutagenesis analyses of the asymmetric charge distribution on calmodulin
Weber, P. C., Lukas, T. J., Craig, T. A., Wilson, E., King, M. M., Kwiatkowski, A. P., & Watterson, D. M. (1989) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340060107 · Cited by 55
Conformational changes underlying calcium/calmodulin‐dependent protein kinase II activation
Hoffman, L., Stein, R. A., Colbran, R. J., & Mchaourab, H. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.40 · Cited by 54
Loss of Calcium/Calmodulin-dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP
Ashpole, N. M., Chawla, A., Martin, M. P., Brustovetsky, T., Brustovetsky, N., & Hudmon, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.466235 · Cited by 52
From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome
Cramer, N., & Galdzicki, Z. (2012) · Neural Plasticity · doi:10.1155/2012/101542 · Cited by 60
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
Perfitt, T. L., Wang, X., Dickerson, M. T., Stephenson, J. R., Nakagawa, T., Jacobson, D. A., & Colbran, R. J. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0893-19.2020 · Cited by 54
Mechanism of the Generation of Autonomous Activity of Ca2+/Calmodulin-dependent Protein Kinase IV
Tokumitsu, H., Hatano, N., Inuzuka, H., Yokokura, S., Nozaki, N., & Kobayashi, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406534200 · Cited by 54
Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation
Miller, C. A., & Sweatt, J. D. (2006) · Learning & Memory · doi:10.1101/lm.304606 · Cited by 53
Global Forebrain Ischemia Induces a Posttranslational Modification of Multifunctional Calcium‐ and Calmodulin‐Dependent Kinase II
Churn, S. B., Taft, W. C., Billingsley, M. S., Sankaran, B., & DeLorenzo, R. J. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08431.x · Cited by 53
The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation
Engholm‐Keller, K., Waardenberg, A. J., Müller, J. A., Wark, J. R., Fernando, R. N., Arthur, J. W., Robinson, P. J., Dietrich, D., Schoch, S., & Graham, M. E. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000170 · Cited by 51
Intracellular signals that mediate thymic negative selection
Vasquez, N. J., Kane, L., & Hedrick, S. Μ. (1994) · Immunity · doi:10.1016/1074-7613(94)90008-6 · Cited by 52
Studies on the generation of Ca2+/calmodulin-independent activity of calmodulin-dependent protein kinase II by autophosphorylation. Autothiophosphorylation of the enzyme
Ikeda, A., Okuno, S., & Fujisawa, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98996-9 · Cited by 51
Bidirectional changes in synapsin I phosphorylation at MAP kinase‐dependent sites by acute neuronal excitation in vivo
Yamagata, Y., Jovanovic, J. N., Czernik, A. J., Greengard, P., & Obata, K. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00753.x · Cited by 49
Self-citation
Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.
Lickteig, R. L., Shenolikar, S., Denner, L. A., & Kelly, P. T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37414-3 · Cited by 48
Enzymatic Gating of Voltage‐Activated Calcium Channels
Armstrong, D. L., Rossier, M. F., Shcherbatko, A., & White, R. E. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb36478.x · Cited by 47
Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation.
DeRemer, M., Saeli, R. J., Brautigan, D. L., & Edelman, A. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42235-1 · Cited by 47
New Aspects of Neurotransmitter Release and Exocytosis: Dynamic and Differential Regulation of Synapsin I Phosphorylation by Acute Neuronal Excitation In Vivo
Yamagata, Y. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.22 · Cited by 46
Autophosphorylation-Dependent Activation of a Calcium-Dependent Protein Kinase from Groundnut1
Chaudhuri, S., Seal, A., & DasGupta, M. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.120.3.859 · Cited by 46
Phosphorylation-dependent Reversible Association of Ca2+/Calmodulin-dependent Protein Kinase II with the Postsynaptic Densities
Yoshimura, Y., & Yamauchi, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26354 · Cited by 46
A brain-specific Ca2+/calmodulin-dependent protein kinase (CaM kinase-Gr) is regulated by autophosphorylation. Relevance to neuronal Ca2+ signaling
Frangakis, M. V., Ohmstede, C. A., & Sahyoun, N. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99164-7 · Cited by 46
Two Developmentally Regulated Isoenzymes of Calmodulin‐Stimulated Protein Kinase II in Rat Forebrain
Rostas, J. A. P., Seccombe, M. A., & Weinberger, R. P. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb03003.x · Cited by 46
Characterization of a soluble Mr‐30000 catalytic fragment of the neuronal calmodulin‐dependent protein kinase II
LeVine, H., & Sahyoun, N. E. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13442.x · Cited by 46
CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling
Maier, L. S. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000900002 · Cited by 45
Spatial and Temporal Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Developing Neurons
Menegon, A., Verderio, C., Leoni, C., Benfenati, F., Czernik, A. J., Greengard, P., Matteoli, M., & Valtorta, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07016.2002 · Cited by 44
Self-citation
Cellular and molecular pathways controlling muscle size in response to exercise
Attwaters, M., & Hughes, S. M. (2021) · FEBS Journal · doi:10.1111/febs.15820 · Cited by 47
Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+/calmodulin‐dependent kinase II
Seeger, C., Talibov, V., & Danielson, U. H. (2017) · Journal of Molecular Recognition · doi:10.1002/jmr.2621 · Cited by 44
Ca2+-independent Activation of Ca2+/Calmodulin-dependent Protein Kinase II Bound to the C-terminal Domain of CaV2.1 Calcium Channels
Magupalli, V. G., Mochida, S., Yan, J., Jiang, X. J., Westenbroek, R. E., Nairn, A. C., Scheuer, T., & Catterall, W. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.369058 · Cited by 43
Self-citation
In Vivo and In Vitro Characterization of the Sequence Requirement for Oligomer Formation of Ca2+/Calmodulin‐Dependent Protein Kinase IIα
Shen, K., & Meyer, T. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70010096.x · Cited by 43
Active catalytic fragment of Ca2+/calmodulin-dependent protein kinase II. Purification, characterization, and structural analysis
Yamagata, Y., Czernik, A. J., & Greengard, P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98628-x · Cited by 43
Self-citation
Plasmodium falciparum calcium-dependent protein kinase phosphorylates proteins of the host erythrocytic membrane
Zhao, Y., Franklin, R. M., & Kappes, B. (1994) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(94)90159-7 · Cited by 42
Differential Effects of a Calcineurin Inhibitor on Glutamate-induced Phosphorylation of Ca2+/Calmodulin-dependent Protein Kinases in Cultured Rat Hippocampal Neurons
Kasahara, J., Fukunaga, K., & Miyamoto, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9061 · Cited by 42
Kindling induced changes in calmodulin kinase II immunoreactivity
Bronstein, J. M., Farber, D. B., Micevych, P. E., Lasher, R. S., & Wasterlain, C. G. (1990) · Brain Research · doi:10.1016/0006-8993(90)90490-3 · Cited by 42
Saccharomyces cerevisiae protein kinase dependent on Ca2+ and calmodulin
Miyakawa, T., Oka, Y., Tsuchiya, E., & Fukui, S. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.3.1417-1422.1989 · Cited by 42
Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells
Aletta, J. M., Selbert, M. A., Nairn, A. C., & Edelman, A. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20930 · Cited by 41
Self-citation
Regulation of the rabbit ileal brush-border Na+/H+ exchanger by an ATP-requiring Ca++/calmodulin-mediated process.
Rood, R. P., Emmer, E., Wesolek, J. H., McCullen, J., Husain, Z., Cohen, M. E., Braithwaite, R. S., Murer, H., Sharp, G. W. G., & Donowitz, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113665 · Cited by 41
Protein Kinase C and its Role in Cell Growth
Woodgett, J. R., Hunter, T. R., & Gould, K. L. (1987) · Springer eBooks · doi:10.1007/978-1-4613-1915-3_6 · Cited by 41
Switching characteristics of a model for biochemical-reaction networks describing autophosphorylation versus dephosphorylation of Ca2+/calmodulin-dependent protein kinase II
Okamoto, H., & Ichikawa, K. (2000) · Biological Cybernetics · doi:10.1007/pl00007960 · Cited by 41
Calmodulin Regulation of Basal and Agonist‐Stimulated G Protein Coupling by the μ‐Opioid Receptor (OP3) in Morphine‐Pretreated Cell
Wang, D., Surratt, C. K., & Sadée, W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750763.x · Cited by 40
A Retinal Calmodulin‐Dependent Kinase: Calcium/ Calmodulin‐Stimulated and ‐Inhibited States
Bronstein, J. M., Wasterlain, C. G., & Farber, D. B. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb03028.x · Cited by 40
Phosphorylation regulates the activity of the eEF-2-specific Ca(2+)- and calmodulin-dependent protein kinase III.
Nygârd, O., Nilsson, A., Carlberg, U., Nilsson, L., & Amons, R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55316-3 · Cited by 40
Cerebellar GABA B receptors modulate function of GABA A receptors
Hahner, L., McQuilkin, S. J., & Harris, R. A. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.10.1648524 · Cited by 39
Inactivation and Reactivation of the Multifunctional Calmodulin‐Dependent Protein Kinase from Brain by Autophosphorylation and Dephosphorylation: Involvement of Protein Phosphatases from Brain
Saitoh, Y., Yamamoto, H., Fukunaga, K., Matsukado, Y., & Miyamoto, E. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb10022.x · Cited by 39
α‐Synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII
Liu, S., Fà, M., Ninan, I., Trinchese, F., Dauer, W. T., & Arancio, O. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05569.x · Cited by 38
Regulatory Properties of Calcium/Calmodulin‐Dependent Protein Kinase II in Rat Brain Postsynaptic Densities
Rich, D. P., Colbran, R. J., Schworer, C. M., & Soderling, T. R. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb11777.x · Cited by 37
Global Forebrain Ischemia Results in Decreased Immunoreactivity of Calcium/Calmodulin-Dependent Protein Kinase II
Churn, S. B., Yaghmai, A. A., Povlishock, J. T., Rafiq, A., & DeLorenzo, R. J. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.109 · Cited by 37
Control Sites of Ribosomal S6 Kinase B and Persistent Activation through Tumor Necrosis Factor
Tomás-Zuber, M., Mary, J., & Lesslauer, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002586200 · Cited by 34
Kinetic mechanism of the type II calmodulin-dependent protein kinase: studies of the forward and reverse reactions and observation of apparent rapid-equilibrium ordered binding
Kwiatkowski, A. P., Huang, C., & King, M. M. (1990) · Biochemistry · doi:10.1021/bi00453a019 · Cited by 34
Phosphorylation and dephosphorylation of protein in regulating cellular function
Kurosawa, M. (1994) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/1056-8719(94)90075-2 · Cited by 33
Calmodulin-Regulated Protein Kinases
Lukas, T. J., Mirzoeva, S., & Watterson, D. M. (1998) · Elsevier eBooks · doi:10.1016/b978-0-08-092636-0.50007-4 · Cited by 33
Autoactivation of calmodulin-dependent protein kinase II by autophosphorylation.
Katoh, T., & Fujisawa, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49951-6 · Cited by 32
Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins
Lapadula, E. S., Lapadula, D. M., & Abou-Donia, M. B. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90174-p · Cited by 31
Pyruvate Prevents the Inhibition of the Long-term Potentiation Induced by Amyloid-β through Protein Phosphatase 2A Inactivation
Wang, X., Takata, T., Bai, X., Ou, F., Yokono, K., & Sakurai, T. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-101869 · Cited by 29
Kinetics of the inhibition of calcium/calmodulin-dependent protein kinase II by pea protein-derived peptides
Li, H., & Aluko, R. E. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.007 · Cited by 29
Biochemical and functional characterization of the synaptic vesicle-associated form of Ca 2+ /calmodulin-dependent protein kinase II
Benfenati, F., Onofri, F., Czernik, A. J., & Valtorta, F. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00053-8 · Cited by 29
Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders
Onori, M. P., & van Woerden, G. M. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.03.014 · Cited by 30
Studies on the regulatory domain of Ca2+/calmodulin-dependent protein kinase II by expression of mutated cDNAs in Escherichia coli.
Hagiwara, T., Ohsako, S., & Yamauchi, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55312-6 · Cited by 28
Effects of some metal‐ATP complexes on Na(+)‐Ca2+ exchange in internally dialysed squid axons.
DiPolo, R., & Beaugé, L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019544 · Cited by 28
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart
Maier, L. S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_30 · Cited by 27
Functional analysis of Ca2+/calmodulin-dependent protein kinase II expressed in bacteria
Waxham, M. N., Aronowski, J. A., & Kelly, P. T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83259-8 · Cited by 27
Insulin receptor autophosphorylation. I. Autophosphorylation kinetics of the native receptor and its cytoplasmic kinase domain
Kohanski, R. A. (1993) · Biochemistry · doi:10.1021/bi00073a007 · Cited by 27
Conformation-sensitive modification of the type II calmodulin-dependent protein kinase by phenylglyoxal.
King, M. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68848-9 · Cited by 27
Intracellular Regulation of GABAA-Receptor Function
Stelzer, A. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3328-3_4 · Cited by 26
Differential effect of ganglioside GM1 on rat brain phosphoproteins: potentiation and inhibition of protein phosphorylation regulated by calcium/calmodulin and calcium/phospholipid‐dependent protein kinases
Cimino, M., Benfenati, F., Farabegoli, C., Cattabeni, F., Fuxé, K., Agnati, L. F., & Toffano, G. (1987) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1987.tb08143.x · Cited by 27
Alterations of CaMKII after hypoxia‐ischemia during brain development
Tang, K., Liu, C., Kuluz, J. W., & Hu, B. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02733.x · Cited by 26
Modulation of CaM Kinase II Activity Is Coincident with Induction of Status Epilepticus in the Rat Pilocarpine Model
Singleton, M. W., Holbert, W. H., Lee, A. T., Bracey, J. M., & Churn, S. B. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.19205.x · Cited by 26
Phenylalanine positively modulates the cAMP‐dependent phosphorylation and negatively modulates the vasopressin‐induced and okadaic‐acid‐induced phosphorylation of phenylalanine 4‐monooxygenase in intact rat hepatocytes
Døskeland, A. P., Vintermyr, O. K., Flatmark, T., Cotton, R. G. H., & Døskeland, S. O. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16913.x · Cited by 26
Characterization of polyclonal antibodies to brain protein phosphatase 2A and immunohistochemical localization of the enzyme in rat brain
Saitoh, Y., Yamamoto, H., Ushio, Y., & Miyamoto, E. (1989) · Brain Research · doi:10.1016/0006-8993(89)90862-7 · Cited by 26
Intracellular Calcium and Cell Function
Villereal, M. L., & Palfrey, H. C. (1989) · Annual Review of Nutrition · doi:10.1146/annurev.nu.09.070189.002023 · Cited by 25
Localization of mRNA for protein phosphatase 2A in the brain of adult rats
Abe, H., Shima, H., Sekiguchi, M., Guo, H., Nagao, M., Tamura, S., & Kondo, H. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90041-8 · Cited by 25

Authors: Lai, Y., Nairn, A. C., & Greengard, P.
Affiliations: Rockefeller University (US)
ORCID: Nairn, A C
Greengard, P
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1986-06
Volume: 83
Issue: 12
Pages: 4253-4257
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.83.12.4253
PMC: PMC323710
OpenAlex: W2011962611
Cited by: 292
References: 33
Citations by year: 2026: 1 · 2025: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 6
FWCI: 10.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium/calmodulin-dependent protein kinase II, autophosphorylation, kinase regulation, synapsin I, protein phosphatase 2A, dephosphorylation, ATP requirement, enzyme activation
MeSH terms: Adenosine Triphosphate, Animals, Calcium, Calmodulin, Enzyme Activation, Hot Temperature, Kinetics, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinases, Structure-Activity Relationship, Rats, Protein Phosphatase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks