Cited by 292Protein Kinase Regulation and GTPase SignalingSignaling Pathways in DiseaseNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

Open access

Lai, Y, Nairn, A C, Greengard, P·1986·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.83.12.4253PMC PMC323710

Open this paper in CoChat — free account

Abstract

Ca2+/calmodulin-dependent protein kinase II contains two subunits, alpha (Mr 50,000) and beta (Mr 60,000/58,000), both of which undergo Ca2+/calmodulin-dependent autophosphorylation. In the present study, we have studied the mechanism of this autophosphorylation reaction and its effect on the activity of the enzyme. Both subunits are autophosphorylated through an intramolecular mechanism. Using synapsin I as substrate, Ca2+/calmodulin-dependent protein kinase II, in its unphosphorylated form, was totally dependent on Ca2+ and calmodulin for its activity. Preincubation of the enzyme with Ca2+, calmodulin, and ATP, under conditions where autophosphorylation of both subunits occurred, converted the enzyme to one that was only partially dependent on Ca2+ and calmodulin for its activity. No change in the total activity, measured in the presence of Ca2+ and calmodulin, was observed. The nonhydrolyzable ATP analog adenosine 5'-[beta, gamma-imido] triphosphate did not substitute for ATP in the preincubation. Moreover, dephosphorylation of autophosphorylated Ca2+/calmodulin-dependent protein kinase II with protein phosphatase 2A resulted in an enzyme that was again totally dependent on Ca2+ and calmodulin for its activity. We propose that autophosphorylation and dephosphorylation reversibly regulate the Ca2+ and calmodulin requirement of Ca2+/calmodulin-dependent protein kinase II.

Integrity signals

Registry

Crossref · 10.1073/pnas.83.12.4253

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A simplification of the protein assay method of Lowry et al. which is more generally applicable
Peterson, G. L. (1977) · Analytical Biochemistry · doi:10.1016/0003-2697(77)90043-4 · Cited by 8,531
Calmodulin Plays a Pivotal Role in Cellular Regulation
Cheung, W. Y. (1980) · Science · doi:10.1126/science.6243188 · Cited by 2,434
Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch
Miller, S. (1986) · Cell · doi:10.1016/0092-8674(86)90008-5 · Cited by 864
Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.
Llinas, R. H., McGuinness, T. L., Leonard, C. S., Sugimori, M., & Greengard, P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.3035 · Cited by 641
Self-citation
PROTEIN KINASES IN THE BRAIN
Naira, A. C., Hemmings, H. C., & Greengard, P. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004435 · Cited by 551
Self-citation
Phosphorylation activates the insulin receptor tyrosine protein kinase.
Rosen, O. M., Herrera, R., Olowe, Y., Petruzzelli, L., & Cobb, M. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3237 · Cited by 545
Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.
Bennett, M. K., Erondu, N. E., & Kennedy, M. B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44239-6 · Cited by 481
Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.
Ueda, T., & Greengard, P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40170-0 · Cited by 407
Self-citation
Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins.
Goldenring, J. R., Gonzalez, B. I., McGuire, J. S., & DeLorenzo, R. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44223-2 · Cited by 339
Distinct forebrain and cerebellar isozymes of type II Ca2+/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction.
Miller, S. G., & Kennedy, M. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39454-1 · Cited by 304

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 201–292 of 292

Developmental changes in protein phosphorylation in chicken forebrain. II. Calmodulin stimulated phosphorylation
Weinberger, R. P., & Rostas, J. A. P. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90104-6 · Cited by 25
Depression of Ca2+/calmodulin‐dependent protein kinase II in dorsal root ganglion neurons after spinal nerve ligation
Kojundžić, S. L., Puljak, L., Hogan, Q. H., & Sapunar, D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22209 · Cited by 24
Detection of Protein Phosphatase Activities in Sodium Dodecyl Sulfate–Polyacrylamide Gel Using Peptide Substrates
Kameshita, I., Ishida, A., Okuno, S., & Fujisawa, H. (1997) · Analytical Biochemistry · doi:10.1006/abio.1996.9945 · Cited by 24
Heparin Inhibits Phosphorylation and Autonomous Activity of Ca2+/Calmodulin-Dependent Protein Kinase II in Vascular Smooth Muscle Cells
Mishra-Gorur, K., Singer, H. A., & Castellot, J. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64465-3 · Cited by 24
The Camp Cascade in the Nervous System: Molecular Sites of Action and Possible Relevance TO Neuronal Plasticit
Dudai, Y. (1987) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238709101484 · Cited by 24
Modulation of mammalian cardiac AMP deaminase by protein kinase C-mediated phosphorylation
Thakkar, J. K., Janero, D. R., Yarwood, C., & Sharif, H. M. (1993) · Biochemical Journal · doi:10.1042/bj2910523 · Cited by 24
Possible role for calmodulin and the Ca2+/calmodulin-dependent protein kinase II in postsynaptic neurotransmission.
Siekevitz, P. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.12.5374 · Cited by 23
FRET-based sensor for CaMKII activity (FRESCA): A useful tool for assessing CaMKII activity in response to Ca2+ oscillations in live cells
Ardestani, G., West, M. C., Maresca, T. J., Fissore, R. A., & Stratton, M. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009235 · Cited by 23
CaMKII Inhibition is a Novel Therapeutic Strategy to Prevent Diabetic Cardiomyopathy
Veitch, C. R., Power, A., & Erickson, J. R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.695401 · Cited by 23
Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy
Tsujioka, S., Sumino, A., Nagasawa, Y., Sumikama, T., Flechsig, H., Puppulin, L., Tomita, T., Baba, Y., Kakuta, T., Ogoshi, T., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh1069 · Cited by 22
Identification of a Prostaglandin-responsive Element in the Na,K-ATPase β1 Promoter That Is Regulated by cAMP and Ca2+
Matlhagela, K., Borsick, M., Rajkhowa, T., & Taub, M. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411415200 · Cited by 23
Effect of prenatal and postnatal ethanol exposure on Ca2+ /calmodulin-dependent protein kinase II in rat cerebral cortex.
Mahadev, K., Chetty, C., & Vemuri, M. (2001) · Alcohol · doi:10.1016/s0741-8329(01)00133-1 · Cited by 22
Calcium/calmodulin-dependent protein kinase II: role in learning and memory
Soderling, T. R. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2600-1_8 · Cited by 22
Characterization of a Novel Calcium/Calmodulin-Dependent Protein Kinase from Tobacco
Ma, L., Liang, S., Jones, R. L., & Lu, Y. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.041970 · Cited by 22
Purification and characterization of bovine brain calmodulin-dependent protein kinase II. The significance of autophosphorylation in the regulation of 63 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme
Zhang, G. Y., Wang, J. H.-C., & Sharma, R. K. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076100 · Cited by 22
The cardiac CaMKII-Nav1.5 relationship: From physiology to pathology
Takla, M., Huang, C. L.-H., & Jeevaratnam, K. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.12.014 · Cited by 21
Propofol and Ketamine-induced Anesthetic Depth-dependent Decrease of CaMKII Phosphorylation Levels in Rat Hippocampus and Cortex
Cui, X., Li, J., Li, T., Ji, F., Bu, X., Zhang, N., & Zhang, B. (2009) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e31819ac2c0 · Cited by 21
A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area.
Miyamoto, E., & Fukunaga, K. (1996) · Neurosciences research · doi:10.1016/0168-0102(95)00991-4 · Cited by 22
Dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II in βTC3-cells is mediated by Mg2+- and okadaic-acid-sensitive protein phosphatases
EASOM, A. R., TARPLEY, L. J., FILLER, R. N., & Bhatt, H. S. (1998) · Biochemical Journal · doi:10.1042/bj3290283 · Cited by 21
Modeling CaMKII in cardiac physiology: from molecule to tissue
Önal, B., Unudurthi, S. D., & Hund, T. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00009 · Cited by 23
Phosphorylation and activation of Ca2+/calmodulin‐dependent protein kinase phosphatase by Ca2+/calmodulin‐dependent protein kinase II
Kameshita, I., Ishida, A., & Fujisawa, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00958-8 · Cited by 20
Autophosphorylation of neuronal calcium/calmodulin-stimulated protein kinase II
Dunkley, P. (2008) · Molecular Neurobiology · doi:10.1007/bf02935545 · Cited by 5
Regulation of Ca2+/calmodulin-dependent protein kinase from Trypanosoma cruzi
Ogueta, S. B., Intosh, G. M., & Téllez-Iñón, M. T. (1996) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(96)02622-9 · Cited by 19
Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase
Kwiatkowski, A. P., & King, M. M. (1987) · Biochemistry · doi:10.1021/bi00398a016 · Cited by 19
Zea mays CCaMK: autophosphorylation‐dependent substrate phosphorylation and down‐regulation by red light
Pandey, S., & Sopory, S. K. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.357.691 · Cited by 18
Distribution of Calmodulin‐ and Cyclic AMP‐Stimulated Protein Kinases in Synaptosomes
Dunkley, P. R., Jarvie, P. E., & Rostas, J. A. P. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb04835.x · Cited by 18
The Insulin Receptor Tyrosine Kinase
Rothenberg, P., White, M. F., & Kahn, C. R. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-74098-5_11 · Cited by 18
Ca2+/calmodulin and Ca2+/phospholipid-dependent protein kinases in the neural tissue of the honeybee Apis mellifera
Altfelder, K., Müller, U., & Menzel, R. (1991) · Insect Biochemistry · doi:10.1016/0020-1790(91)90101-j · Cited by 18
A Ca2+‐Dependent Protein Kinase Activity Associated with Serotonin Binding Protein
Adlersberg, M., Liu, K., Hsiung, S., Ehrlich, Y. H., & Tamir, H. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb10000.x · Cited by 18
Antibody specific for the Thr-286-autophosphorylated alpha subunit of Ca2+/calmodulin-dependent protein kinase II.
Suzuki, T., Okumura-Noji, K., Ogura, A., Kudo, Y., & Tanaka, R. (1992) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.89.1.109 · Cited by 20
Autophosphorylation‐dependent inactivation of plant chimeric calcium/calmodulin‐dependent protein kinase
Sathyanarayanan, P. V., & Poovaiah, B. W. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02904.x · Cited by 16
Deltamethrin causes changes in protein phosphorylation activities associated with post-depolarization events in the synaptosomes from the optic lobe of squid, Loligo pealei
Matsumura, F., Clark, J. M., & Matsumura, F. M. (1989) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(89)90086-8 · Cited by 16
Switching dynamics and the transient memory storage in a model enzyme network involving Ca 2+ calmodulin-dependent protein kinase II in synapses
Matsushita, T., Moriyama, S., & Fukai, T. (1995) · Biological Cybernetics · doi:10.1007/bf00199892 · Cited by 15
Calcium/Calmodulin‐Dependent Protein Kinase II in Squid Synaptosomes
Bass, M., Pant, H. C., Gainer, H., & Soderling, T. R. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb10001.x · Cited by 15
Developmental changes in phosphorylation of MAP-2 and synapsin I in cytosol and taxol polymerised microtubules from chicken brain
Koszka, C., Brent, V. A., & Rostas, J. A. P. (1991) · Neurochemical Research · doi:10.1007/bf00965549 · Cited by 14
Stage‐Specific Substrate Phosphorylation by a Ca2+/Calmodulin‐Dependent Protein Kinase in Trypanosoma cruzi
Ogueta, S. B., MacIntosh, G. C., & Téllez‐No̊n, M. T. (1998) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.1998.tb05089.x · Cited by 14
[9] Isolation and characterization of calmodulin-dependent myosin heavy chain kinase from intestinal brush border
Rieker, J. P., Swanljung-Collins, H., Montibeller, J. A., & Collins, J. H. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)39078-0 · Cited by 14
Ca2+/Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase (PDE1)
Sharma, R. K., & Hickie, R. A. (1996) · Elsevier eBooks · doi:10.1016/b978-012210720-7/50006-x · Cited by 13
Pharmacological profiling of a berbamine derivative for lymphoma treatment
Xu, S., Wu, S., Zhang, M., Xie, J., Lin, M., Jin, L., Zhang, J., Wang, Y., Fan, M., Fang, Z., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010873 · Cited by 12
Inhibition of phosphatase activity facilitates the formation and maintenance of NMDA-induced calcium/calmodulin-dependent protein kinase ii clusters in hippocampal neurons
Tao-Cheng, J.-H., Vinade, L., Winters, C. A., Reese, T. S., & Dosemeci, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.008 · Cited by 12
Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border.
Rieker, J. P., Swanljung-Collins, H., & Collins, J. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48169-0 · Cited by 12
Characterization of Ca2+/calmodulin-dependent protein kinase II from smooth muscle
Zhou, Z., Ando, S., Furutsuka, D., & Ikebe, M. (1995) · Biochemical Journal · doi:10.1042/bj3100517 · Cited by 11
Current Theories of Neuronal Information Processing Performed By Ca2+/Calmodulin-dependent Protein Kinase II with Support and Insights From Computer Modelling and Simulation
Coomber, C. J. (1998) · Computers and Chemistry · doi:10.1016/s0097-8485(97)00002-8 · Cited by 12
Independent Protein Kinases Associated with the Rat Cerebral Synaptic Junction: Comparison with Cyclic AMP‐Dependent and Ca2+/Calmodulin‐Dependent Protein Kinases in the Synaptic Junction
Suzuki, T., Fujii, T., & Tanaka, R. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05728.x · Cited by 10
Purification and characterization of calmodulin-stimulated protein kinase II from two-day and adult chicken forebrain
Rostas, J. A. P., Brent, V. A., Seccombe, M. A., Weinberger, R. P., & Dunkley, P. R. (1989) · Journal of Molecular Neuroscience · doi:10.1007/bf02896893 · Cited by 10
Characterization of calcium/calmodulin-dependent protein kinase II isoforms from forebrain and cerebellum
Yamauchi, T., Sekihara, S.-I., & Ohsako, S. (1991) · Brain Research · doi:10.1016/0006-8993(91)91019-w · Cited by 9
Food Protein–Derived Peptides as Calmodulin Inhibitors
Aluko, R. E. (2010) · doi:10.1002/9780813811048.ch5 · Cited by 9
Interactions between αCaMKII and calmodulin in living cells: conformational changes arising from CaM -dependent and -independent relationships
Kato, K.-I., Iwamoto, T., & Kida, S. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-37 · Cited by 8
Identification of Pin1-Binding Phosphorylated Proteins in the Mouse Brain
Tatara, Y., Terakawa, T., & Uchida, T. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100580 · Cited by 8
Second messenger systems and adaptation.
Gorelick, F. S. (1987) · Gut · doi:10.1136/gut.28.suppl.79 · Cited by 8
Activation is only the beginning: mechanisms that tune kinase substrate specificity
Clark, L. K., & Cullati, S. N. (2025) · Biochemical Society Transactions · doi:10.1042/bst20241420 · Cited by 7
Molecular Mechanism of Learning and Memory Based on the Research for Ca2+/Calmodulin-dependent Protein Kinase II
Yamauchi, T. (2007) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.127.1173 · Cited by 7
Ganglioside GM1 modulation of calcium/calmodulin-dependent protein kinase II activity and autophosphorylation
Benfenati, F., Fuxe, K., & Agnati, L. (1991) · Neurochemistry International · doi:10.1016/0197-0186(91)90011-2 · Cited by 5
PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus
Lee, D.-S., Kim, T. H., Park, H., & Kim, J.-E. (2023) · Scientific Reports · doi:10.1038/s41598-023-41014-7 · Cited by 6
Action of deltamethrin on the calcium/calmodulin‐dependent protein kinase from the rat brain
Enan, E. E., & Matsumura, F. (1993) · Pesticide Science · doi:10.1002/ps.2780370105 · Cited by 6
Calmodulin and calmodulin-binding proteins of Rhodosporidium toruloides, a basidiomycetous yeast
Liu, Y., Ohki, O., Azuma, Y., Tachikawa, T., Tsuchiya, E., Fukui, S., & Miyakawa, T. (1990) · Journal of General Microbiology · doi:10.1099/00221287-136-1-131 · Cited by 6
Serine/threonine‐specific protein kinase activity associated with viral pp60src protein
David-Pfeuty, T., & Nouvian-Dooghe, Y. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19194.x · Cited by 5
Enhancement of neurotransmitter release from invertebrate synaptosomes by pyrethroids during pulsed‐depolarization: A functional assay for effects on repolarization
Clark, J. M., & Matsumura, F. (1991) · Pesticide Science · doi:10.1002/ps.2780310109 · Cited by 5
Assay and Purification of Calmodulin-Dependent Protein Kinase
Sharma, R. K. (2005) · Humana Press eBooks · doi:10.1385/1-59259-949-4:305 · Cited by 5
Calmodulinwdependent protein kinase II from bovine cardiac muscle: purification and differential activation by calcium
Kakkar, R., Raju, R. V. S., & Sharma, R. K. (1996) · Cell Calcium · doi:10.1016/s0143-4160(96)90040-8 · Cited by 4
Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins
Suzuki, T., Ando, K., Iijima, K., Oguchi, S., & Takeda, S. (2003) · Humana Press eBooks · doi:10.1385/1-59259-195-7:271 · Cited by 3
Serine/Threonine Protein Phosphatases in Apoptosis
Gausdal, G., Krakstad, C., Herfindal, L., & Døskeland, S. O. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-199-4_7 · Cited by 3
Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II: Effects on Interaction between Enzyme and Substrate
Yasugawa, S., Fukunaga, K., Yamamoto, H., Miyakawa, T., & Miyamoto, E. (1991) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)39958-5 · Cited by 3
Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA
Palmelund, L. B., van Woerden, G. M., Bräuner‐Osborne, H., & Wellendorph, P. (2022) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2022.107226 · Cited by 2
A Novel Histone-stimulated Protein Kinase in Normal and Psoriatic Epidermis
Takematsu, H., Fisher, G. J., & Voorhees, J. J. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12277226 · Cited by 2
ACTIVATION OF Ca2+/CALMODULIN-DEPENDENT PROTEIN KINASE II BY AUTOPHORYLATION: SPECIFIED SUBSTRATES ENHANCE THE KINASE ACTIVITY
TASUGAWA, S., Fukunaga, K., Yamamoto, H., Miyakawa, T., & Miyamoto, E. (1988) · Biomedical Research · doi:10.2220/biomedres.9.497 · Cited by 2
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain—beyond classic receptors
Wellendorph, P., Gauger, S. J., Andersen, J. V., Kornum, B. R., Solbak, S. M. Ø., & Frølund, B. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100064 · Cited by 2
CaMKIIα holoenzymes self-organize into chain-like mesoscale clusters
Suzuki, T., Sumikama, T., Matsushima, K., Hasegawa, K., Sumino, A., Umeda, K., Kodera, N., Das, T., Beta, C., Murakoshi, H., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg0958 · Cited by 1
CDPKs in Plant Signaling Networks
Gupta, M. D., & Chaudhuri, S. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1365-0_15 · Cited by 1
Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction
Lee, A. M., & Picciotto, M. R. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.09.002 · Cited by 1
Autophosphorylation: a salient feature of protein kinases
Smith, J. A., Francis, S. H., & Corbin, J. D. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2600-1_5 · Cited by 1
Various cases of rapid-equilibrium ordered bireactant mechanisms - their bases and differentiation
Huang, C. (1990) · Biochemistry · doi:10.1021/bi00453a020 · Cited by 1
Methods and Resources
(2009) · Chemical industries · doi:10.1201/9781420059656-p8 · Cited by 1
Analysis of Protein Phosphorylation in Intact Cells and Extracts
Walaas, S. I., & Østvold, A. C. (2003) · Humana Press eBooks · doi:10.1385/0-89603-415-1:1 · Cited by 1
Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II By Autophosphorylation/Dephosphorylation
Kelly, P. T., Licktelg, R., & Shenolikar, S. (1987) · Calcium-Binding Proteins in Health and Disease · doi:10.1016/b978-0-12-521040-9.50035-8 · Cited by 1
Ca2+/calmodulin‐dependent protein kinase and neuronal function
Mayford, M. R. (1996) · doi:10.1002/9783527615032.ch5
Calcium/Calmodulin‐Dependent Protein Kinase II (CaMKII)—Modulation of Ion Currents and Potential Role for Arrhythmias
Maier, L. S. (2009) · doi:10.1002/9780470561416.ch12
Die Effekte der Ca2+-Calmodulin-abhängigen Proteinkinase II (CaMKII) auf die Aktionspotential-morphologie bei mechanischer Last
Gupta, S. N. (2013) · doi:10.53846/goediss-4092
Phosphoproteins and the Regulation of Vesicular Neurotransmitter Release
Hens, J. J. H., Hoogland, G., Gispen, W. H., & Graan, P. N. E. D. (1997) · Springer eBooks · doi:10.1007/978-3-642-60704-2_11
Ca²⁺/calmodulin dependent protein kinase II subcellular re-distribution and activation of protein phosphatase after a brief pentylenetertrazol seizure : potential role in kindling.
Dong, Y. (2003) · OhioLink ETD Center (Ohio Library and Information Network)
Die Rolle des späten Natrium-Stroms bei der Kalzium-Calmodulin-abhängigen ProteinkinaseIIδC (CaMKIIδC)-induzierten Herzinsuffizienz und beim chronischen Vorhofflimmern
Maurer, U. (2012) · doi:10.53846/goediss-1557
Die Rolle des späten Natriumstroms (late INa) bei Druck-induzierter Hypertrophie und bei Herzinsuffizienz
Hartmann, N. (2015) · doi:10.53846/goediss-4971
Einfluss der Ca2+/Calmodulin-abhängigen Proteinkinase II delta auf den L-Typ Ca2+-Strom -Untersuchungen anhand eines genetischen Knock-outs im Mausmodell
Neuhaus, V. (2016) · doi:10.53846/goediss-6052
THE ROLE OF Ca2+/CALMODULIN-DEPENDENT PROTEIN KINASE II IN NEURONAL FUNCTIONS11This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. On leave from Departments
Miyamoto, E., Fukunaga, K., Ohta, Y., Yamamoto, H., Yasugawa, S., Goto, S., & Ohba, T. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-375655-8.50010-x
Mechanisms of Action of Drugs Which Alter Aqueous Humour Formation
Shahidullah (1994) · Enlighten: Theses (The University of Glasgow)
The role of Ca2+/calmodulin-dependent kinase II in normal and abnormal early postnatal development
Gustin, R. M. (2010)
Investigation of CaMKII activation: a model of self-regulation
Hoffman, L. (2011)
Inhibtion der Ca2+/Calmodulin-abhängigen Proteinkinase (CaMKII) verbessert die Kontratilität von terminal insuffizientem Myokard des Menschen
Fluschnik, N. (2011) · doi:10.53846/goediss-1131
Die Bedeutung der Proteinkinase A und der Ca2+/Calmodulin abhängigen Proteinkinase II für das Sarkoplasmatische Retikulum Kalziumleck in der humanen Hypertrophie und Herzinsuffizienz
Herting, J. (2022) · doi:10.53846/goediss-9451
Characterization of Autonomous and Ca2+/Calmodulin-Dependent Activities of CaMKK Isoforms In Vitro and in Mouse Tissues
Ohtsuka, S., Chen, Y., Magari, M., Ishikawa, T., Sakagami, H., Suizu, F., & Tokumitsu, H. (2025) · Biochemistry · doi:10.1021/acs.biochem.5c00477
CaMKII-RNMT axis directs activity-dependent control of RNA dynamics in neuronsPreprint
Almohammed, R., Liang, S., Bage, M., Hepburn, L. A., Davidson, L., Haward, F., Prescott, A. R., Yoshikawa, H., Lamond, A. I., Pisliakov, A. V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685591
BindingDB Entry 50022513: KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
BindingDB (2025) · UC San Diego · doi:10.7270/q24f1wgr

Authors: Lai, Y., Nairn, A. C., & Greengard, P.
Affiliations: Rockefeller University (US)
ORCID: Nairn, A C
Greengard, P
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1986-06
Volume: 83
Issue: 12
Pages: 4253-4257
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.83.12.4253
PMC: PMC323710
OpenAlex: W2011962611
Cited by: 292
References: 33
Citations by year: 2026: 1 · 2025: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 6
FWCI: 10.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium/calmodulin-dependent protein kinase II, autophosphorylation, kinase regulation, synapsin I, protein phosphatase 2A, dephosphorylation, ATP requirement, enzyme activation
MeSH terms: Adenosine Triphosphate, Animals, Calcium, Calmodulin, Enzyme Activation, Hot Temperature, Kinetics, Phosphoprotein Phosphatases, Phosphorylation, Protein Kinases, Structure-Activity Relationship, Rats, Protein Phosphatase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks