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Involvement of brain opiate receptors in the immune-suppressive effect of morphine.
Open accessAbstract
We previously reported that a single systemic injection of a high dose of morphine (greater than or equal to 20 mg/kg) transiently suppresses splenic natural killer cell cytotoxicity in rats. The present study examined the possibility that the immune-suppressive effect of morphine is mediated by opiate receptors in the brain. Supporting this hypothesis, we found that morphine (20 or 40 micrograms) injected into the lateral ventricle suppressed natural killer cell activity to the same degree as a systemic dose higher by three orders of magnitude. This effect was blocked by an opiate antagonist, naltrexone. Natural killer cell activity was unaffected by systemic administration of N-methyl morphine, a morphine analogue that does not cross the blood-brain barrier. These data implicate opiate receptors in the brain in morphine-induced suppression of natural killer cell cytotoxicity.
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Cites
Noradrenergic and peptidergic innervation of lymphoid tissue
Felten, D. L., Felten, S. Y., Carlson, S. L., Olschowka, J. A., & Livnat, S. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.755 · Cited by 1,025
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Opioid Therapy and Immunosuppression: A Review
Vallejo, R., de Leon-Casasola, O., & Benyamin, R. (2004) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000132250.95650.85 · Cited by 386
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
Opioid Guidelines in the Management of Chronic Non-Cancer Pain
Manchikanti, L. (2006) · Pain Physician · doi:10.36076/ppj.2006/9/2 · Cited by 277
Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations
Eisenstein, T. K., & Hilburger, M. E. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00219-1 · Cited by 262
Metadata
- Authors
- Shavit, Y., Depaulis, A., Martin, F. C., Terman, G. W., Pechnick, R. N., Zane, C. J., Gale, R. P., & Liebeskind, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-09
- Volume
- 83
- Issue
- 18
- Pages
- 7114-7117
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021168999
- Cited by
- 221
- References
- 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Shavit, Y., Depaulis, A., Martin, F. C., Terman, G. W., Pechnick, R. N., Zane, C. J., Gale, R. P., & Liebeskind, J. C. (1986). Involvement of brain opiate receptors in the immune-suppressive effect of morphine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.18.7114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
