The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Random-clone strategy for genomic restriction mapping in yeast.
Open accessAbstract
An approach to global restriction mapping is described that is applicable to any complex source DNA. By analyzing a single restriction digest for each member of a redundant set of lambda clones, a data base is constructed that contains fragment-size lists for all the clones. The clones are then grouped into subsets, each member of which is related to at least one other member by a significant overlap. Finally, a tree-searching algorithm seeks restriction maps that are consistent with the fragment-size lists for all the clones in each subset. The feasibility of the approach has been demonstrated by collecting data on 5000 lambda clones containing random 15-kilobase inserts of yeast DNA. It is shown that these data can be analyzed to produce regional maps of the yeast genome, extending in some cases for over 100 kilobases. In combination with hybridization probes to previously cloned genes, these local maps are already useful for defining the physical arrangement of closely linked genes. They may in the future serve as building blocks for the construction of a continuous global map.
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Cites
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Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationKohara, Y., Akiyama, K., & Isono, K. (1987) · Cell · doi:10.1016/0092-8674(87)90503-4 · Cited by 1,741
Genomic mapping by fingerprinting random clones: A mathematical analysis
Lander, E. S., & Waterman, M. S. (1988) · Genomics · doi:10.1016/0888-7543(88)90007-9 · Cited by 961
An STS-Based Map of the Human Genome
Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S.-H., et al. (1995) · Science · doi:10.1126/science.270.5244.1945 · Cited by 773
TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase
Singer, M. S., & Gottschling, D. E. (1994) · Science · doi:10.1126/science.7545955 · Cited by 736
Metadata
- Authors
- Olson, M. V., Dutchik, J. E., Graham, M. Y., Brodeur, G. M., Helms, C., Frank, M., MacCollin, M., Scheinman, R., & Frank, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-10
- Volume
- 83
- Issue
- 20
- Pages
- 7826-7830
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002652302
- Cited by
- 416
- References
- 17
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Olson, M. V., Dutchik, J. E., Graham, M. Y., Brodeur, G. M., Helms, C., Frank, M., MacCollin, M., Scheinman, R., & Frank, T. (1986). Random-clone strategy for genomic restriction mapping in yeast. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.20.7826
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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