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Cited by 773

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

An STS-Based Map of the Human Genome

Hudson, Thomas J., Stein, Lincoln D., Gerety, Sebastian S., Ma, Junli, Castle, Andrew B., Silva, James, Slonim, Donna K., Baptista, Rafael, Kruglyak, Leonid, Xu, Shu-Hua, Hu, Xintong, Colbert, Angela M. E., Rosenberg, Carl, Reeve-Daly, Mary Pat, Rozen, Steve, Hui, Lester, Wu, Xiaoyun, Vestergaard, Christina, Wilson, Kimberly M., Bae, Jane S., Maitra, Shanak, Ganiatsas, Soula, Evans, Cheryl A., DeAngelis, Margaret M., Ingalls, Kimberly A., Nahf, Robert W., Horton, Lloyd T., Anderson, Michele Oskin, Collymore, Alville J., Ye, Wenjuan, Kouyoumjian, Vardouhie, Zemsteva, Irena S., Tam, James, Devine, Richard, Courtney, Dorothy F., Renaud, Michelle Turner, Nguyen, Huy, O'Connor, Tara J., Fizames, Cécile, Fauré, Sabine, Gyapay, Gabor, Dib, Colette, Morissette, Jean, Orlin, James B., Birren, Bruce W., Goodman, Nathan, Weissenbach, Jean, Hawkins, Trevor L., Foote, Simon, Page, David C., Lander, Eric S.·1995·Science

Abstract

A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. The STSs in the map provide a scaffold for initiating large-scale sequencing of the human genome.

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Metadata

Authors
Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S.-H., Hu, X., Colbert, A. M. E., Rosenberg, C., Reeve-Daly, M. P., Rozen, S., Hui, L., Wu, X., Vestergaard, C., Wilson, K. M., Bae, J. S., Maitra, S., Ganiatsas, S., Evans, C. A., DeAngelis, M. M., Ingalls, K. A., Nahf, R. W., Horton, L. T., Anderson, M. O., Collymore, A. J., Ye, W., Kouyoumjian, V., Zemsteva, I. S., Tam, J., Devine, R., Courtney, D. F., Renaud, M. T., Nguyen, H., O'Connor, T. J., Fizames, C., Fauré, S., Gyapay, G., Dib, C., Morissette, J., Orlin, J. B., Birren, B. W., Goodman, N., Weissenbach, J., Hawkins, T. L., Foote, S., Page, D. C., & Lander, E. S.
Venue
Science
Published
1995-12-22
Volume
270
Issue
5244
Pages
1945-1954
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2162068418
Cited by
773
References
32
FWCI
72.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: An STS-Based Map of the Human Genome. https://app.cochat.ai/papers/10.1126/science.270.5244.1945
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Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S.-H., Hu, X., Colbert, A. M. E., Rosenberg, C., Reeve-Daly, M. P., Rozen, S., Hui, L., Wu, X., Vestergaard, C., Wilson, K. M., . . . Lander, E. S. (1995). An STS-Based Map of the Human Genome. Science. https://doi.org/10.1126/science.270.5244.1945

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