The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.
Open accessAbstract
Analysis of MM14 mouse myoblasts demonstrates that terminal differentiation is repressed by pure preparations of both acidic and basic fibroblast growth factor (FGF). Basic FGF is approximately 30-fold more potent than acidic FGF and it exhibits half maximal activity in clonal assays at 0.03 ng/ml (2 pM). FGF repression occurs only during the G1 phase of the cell cycle by a mechanism that appears to be independent of ongoing cell proliferation. When exponentially growing myoblasts are deprived of FGF, cells become postmitotic within 2-3 h, express muscle-specific proteins within 6-7 h, and commence fusion within 12-14 h. Although expression of these three terminal differentiation phenotypes occurs at different times, all are initiated by a single regulatory "commitment" event in G1. The entire population commits to terminal differentiation within 12.5 h of FGF removal as all cells complete the cell cycle and move into G1. Differentiation does not require a new round of DNA synthesis. Comparison of MM14 behavior with other myoblast types suggests a general model for skeletal muscle development in which specific growth factors serve the dual role of stimulating myoblast proliferation and directly repressing terminal differentiation.
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Citations
Cites
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
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Type beta transforming growth factor is an inhibitor of myogenic differentiation.
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Olson, E. N., Sternberg, E., Hu, J. S., Spizz, G., & Wilcox, C. (1986) · The Journal of cell biology · doi:10.1083/jcb.103.5.1799 · Cited by 399
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Diffusion-mediated control of myoblast fusion
Konigsberg, I. R. (1971) · Developmental Biology · doi:10.1016/0012-1606(71)90113-8 · Cited by 278
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Self-citationLinkhart, T. A., Clegg, C. H., & Hauschka, S. D. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90311-0 · Cited by 250
Self-citationIsolation and partial molecular characterization of pituitary fibroblast growth factor.
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Cited by
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,385
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,644
Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation
Rapraeger, A. C., Krufka, A., & Olwin, B. B. (1991) · Science · doi:10.1126/science.1646484 · Cited by 1,508
Self-citationFGF/FGFR signaling in health and disease
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Gossett, L. A., Kelvin, D. J., Sternberg, E. A., & Olson, E. N. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5022 · Cited by 601
Metadata
- Authors
- Clegg, C. H., Linkhart, T. A., Olwin, B. B., & Hauschka, S. D.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1987-08-01
- Volume
- 105
- Issue
- 2
- Pages
- 949-956
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2165220352
- Cited by
- 478
- References
- 27
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Clegg, C. H., Linkhart, T. A., Olwin, B. B., & Hauschka, S. D. (1987). Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor. The Journal of cell biology. https://doi.org/10.1083/jcb.105.2.949
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
