The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein.
Open accessAbstract
By analogy to other retroviruses, the major envelope glycoprotein, gp120, of human T-lymphotropic virus type III (HTLV-III) is a probable target for neutralizing antibody. This antigen has been purified from H9 cells chronically infected with the HTLV-IIIB prototype strain. Several goats immunized with the gp120 produced antibodies that neutralized infection of H9 cells by the homologous virus isolate. These same sera failed to neutralize the divergent HTLV-IIIRF isolate. Individuals infected with HTLV-III commonly develop antibodies to gp120 that could be isolated by using the gp120 antigen coupled to an immunoadsorbent resin. The antibody fraction that bound tightly to such a resin was found to neutralize the IIIB but not the RF isolate in a similar fashion as the goat anti-gp120 sera. However, the nonbinding fraction (effluent) from the resin also contained neutralizing activity that was able to block infection by both virus isolates with similar efficacy. Human antibodies to the other virus envelope gene product, the transmembrane gp41, were also affinity purified by utilizing the recombinant peptide 121, but these failed to influence infection by either virus isolate.
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Cites
Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043
Self-citationStarcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
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Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3978-3988.1993 · Cited by 616
Vaccine protection against simian immunodeficiency virus infection.
Desrosiers, R. C., Wyand, M. S., Kodama, T., Ringler, D. J., Arthur, L. O., Sehgal, P. K., Letvin, N. L., King, N. W., & Daniel, M. D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6353 · Cited by 313
Metadata
- Authors
- Matthews, T. J., Langlois, A. J., Robey, W. G., Chang, N. T., Gallo, R. C., Fischinger, P. J., & Bolognesi, D. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-12
- Volume
- 83
- Issue
- 24
- Pages
- 9709-9713
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2054724326
- Cited by
- 203
- References
- 2
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Matthews, T. J., Langlois, A. J., Robey, W. G., Chang, N. T., Gallo, R. C., Fischinger, P. J., & Bolognesi, D. P. (1986). Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.24.9709
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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