The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Vaccine protection against simian immunodeficiency virus infection.
Open accessAbstract
Rhesus monkeys were immunized by multiple inoculations with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant. Immunized monkeys developed anti-SIV antibodies detectable by whole-virus ELISA and by immunoblot reactivity; these antibodies had weak neutralizing activity. One week after the last immunization, monkeys were challenged with 200-1000 animal infectious doses of uncloned, live SIV. The same strain of SIV that was used for vaccination was also used for challenge. Anamnestic antibody responses and SIV recovery from peripheral blood were used to evaluate infection following the live virus challenge; two of six vaccinated monkeys showed no evidence of infection following the live virus challenge. Transfusion of 10 ml of whole blood from these two into uninfected, naive rhesus monkeys did not result infection of the recipients, providing further support for the lack of infection in the two previously vaccinated animals. Four of four unvaccinated control monkeys inoculated with these doses of live SIV became infected and three of these died with AIDS 118-258 days after infection. Only one of the six vaccinated monkeys has died to date. In situ hybridization with lymph node biopsy specimens suggested that the virus load was much higher in control macaques than in vaccinated macaques. These results indicate that vaccination with inactivated whole virus can protect macaques against challenge with live SIV. Furthermore, they provide hope that vaccine protection against human AIDS virus infection may be possible.
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Citations
Cites
Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques
Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., Kanki, P. J., Essex, M., & Desrosiers, R. C. (1985) · Science · doi:10.1126/science.3159089 · Cited by 920
Self-citationInduction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III
Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985) · Science · doi:10.1126/science.2412295 · Cited by 616
Self-citationChakrabarti, L., Guyader, M., Alizon, M., Daniel, M. D., Desrosiers, R. C., Tiollais, P., & Sonigo, P. (1987) · Nature · doi:10.1038/328543a0 · Cited by 542
Self-citationFukasawa, M., Miura, T., Hasegawa, A., Morikawa, S., Tsujimoto, H., Miki, K., Kitamura, T., & Hayami, M. (1988) · Nature · doi:10.1038/333457a0 · Cited by 334
Allison, A. C., & Byars, N. E. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90402-3 · Cited by 315
Robey, W. G., Arthur, L. O., Matthews, T. J., Langlois, A., Copeland, T. D., Lerche, N. W., Oroszlan, S., Bolognesi, D. P., Gilden, R. V., & Fischinger, P. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.7023 · Cited by 233
Self-citationBaskin, G. B., Murphey-Corb, M., Watson, E. A., & Martin, L. N. (1988) · Veterinary Pathology · doi:10.1177/030098588802500609 · Cited by 228
Matthews, T. J., Langlois, A. J., Robey, W. G., Chang, N. T., Gallo, R. C., Fischinger, P. J., & Bolognesi, D. P. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9709 · Cited by 203
Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees
Hu, S.-L., Fultz, P. N., McClure, H. M., Eichberg, J. W., Thomas, E. K., Zarling, J., Singhal, M. C., Kosowski, S. G., Swenson, R. B., Anderson, D. C., et al. (1987) · Nature · doi:10.1038/328721a0 · Cited by 194
Long-term Persistent Infection of Macaque Monkeys with the Simian Immunodeficiency Virus
Daniel, M. D., Letvin, N. L., Sehgal, P. K., Hunsmann, G., Schmidt, D. K., King, N. W., & Desrosiers, R. C. (1987) · Journal of General Virology · doi:10.1099/0022-1317-68-12-3183 · Cited by 159
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Cited by
Manoussaka, M. S., Berry, N., Ferguson, D., Stebbings, R., Robinson, M., Ham, C., Page, M., Li, B., Das, A. T., Berkhout, B., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-59 · Cited by 16
Metadata
- Authors
- Desrosiers, R. C., Wyand, M. S., Kodama, T., Ringler, D. J., Arthur, L. O., Sehgal, P. K., Letvin, N. L., King, N. W., & Daniel, M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 16
- Pages
- 6353-6357
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065879670
- Cited by
- 313
- References
- 13
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Desrosiers, R. C., Wyand, M. S., Kodama, T., Ringler, D. J., Arthur, L. O., Sehgal, P. K., Letvin, N. L., King, N. W., & Daniel, M. D. (1989). Vaccine protection against simian immunodeficiency virus infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.16.6353
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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