The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
On the specificity of DNA-protein interactions.
Open accessAbstract
In this paper we summarize the various factors that must be considered in establishing the operational specificity of the binding of a protein regulator of gene expression to a DNA target site. We consider informational (combinatorial) aspects of binding-site specification, actual recognition mechanisms, and the thermodynamics of target-site selection against a background of competing pseudospecific and non-(sequence)-specific DNA binding sites. The results provide insight into the design, specification, and possibly the evolution of regulatory proteins and their chromosomal binding targets, as well as into practical aspects of the design of regulatory-protein isolation schemes and physicochemical regulatory considerations in vivo.
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Cites
Weintraub, H., & Groudine, M. (1976) · Science · doi:10.1126/science.948749 · Cited by 1,809
Lin, S.-Y., & Riggs, A. D. (1975) · Cell · doi:10.1016/0092-8674(75)90116-6 · Cited by 338
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Sternberg, S. H., Redding, S., Jinek, M., Greene, E. C., & Doudna, J. A. (2014) · Nature · doi:10.1038/nature13011 · Cited by 1,822
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon
Baichoo, N., Wang, T., Ye, R., & Helmann, J. D. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03113.x · Cited by 250
Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module
McKeown, A. N., Bridgham, J. T., Anderson, D. W., Murphy, M. N., Ortlund, E. A., & Thornton, J. W. (2014) · Cell · doi:10.1016/j.cell.2014.09.003 · Cited by 107
Cooperative binding between distant transcription factors is a hallmark of active enhancers
Rao, S., Ahmad, K., & Ramachandran, S. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.02.014 · Cited by 82
Wang, J., Malecka, A., Trøen, G., & Delabie, J. (2015) · BMC Genomics · doi:10.1186/1471-2164-16-s7-s12 · Cited by 31
“Though the effect of TF on genes requires direct protein-DNA interaction, it has been well-known that additional and different interactions of the TF with the gene are needed for regulation [30].”
Background
Metadata
- Authors
- von Hippel, P. H., & Berg, O. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-03
- Volume
- 83
- Issue
- 6
- Pages
- 1608-1612
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2100305057
- Cited by
- 311
- References
- 2
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- von Hippel, P. H., & Berg, O. G. (1986). On the specificity of DNA-protein interactions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.6.1608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
