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Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.
Open accessAbstract
The effects of hemodynamic forces upon vascular endothelial cell turnover were studied by exposing contact-inhibited confluent cell monolayers to shear stresses of varying amplitude in either laminar or turbulent flow. Laminar shear stresses (range, 8-15 dynes/cm2; 24 hr) induced cell alignment in the direction of flow without initiating the cell cycle. In contrast, turbulent shear stresses as low as 1.5 dynes/cm2 for as short a period as 3 hr stimulated substantial endothelial DNA synthesis in the absence of cell alignment, discernible cell retraction, or cell loss. The results of these in vitro experiments suggest that in atherosclerotic lesion-prone regions of the vascular system, unsteady blood flow characteristics, rather than the magnitude of wall shear stress per se, may be the major determinant of hemodynamically induced endothelial cell turnover.
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Citations
Cited by
Hemodynamic shear stress and its role in atherosclerosis
Malek, A. M. (1999) · JAMA · doi:10.1001/jama.282.21.2035 · Cited by 3,650
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Self-citationChiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force
Traub, O., & Berk, B. C. (1998) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.18.5.677 · Cited by 1,085
Molecular basis of the effects of shear stress on vascular endothelial cells
Li, Y.-S. J., Haga, J. H., & Chien, S. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.09.030 · Cited by 904
Metadata
- Authors
- Davies, P. F., Remuzzi, A., Gordon, E. J., Dewey, C. F., & Gimbrone, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-04
- Volume
- 83
- Issue
- 7
- Pages
- 2114-2117
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2009251691
- Cited by
- 847
- References
- 0
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Davies, P. F., Remuzzi, A., Gordon, E. J., Dewey, C. F., & Gimbrone, M. A. (1986). Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.7.2114
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