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Cited by 1,085

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force

Traub, Oren, Berk, Bradford C.·1998·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/01.atv.18.5.677
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Abstract

Abstract —Mechanical forces are important modulators of cellular function in many tissues and are particularly important in the cardiovascular system. The endothelium, by virtue of its unique location in the vessel wall, responds rapidly and sensitively to the mechanical conditions created by blood flow and the cardiac cycle. In this study, we examine data which suggest that steady laminar shear stress stimulates cellular responses that are essential for endothelial cell function and are atheroprotective. We explore the ability of shear stress to modulate atherogenesis via its effects on endothelial-mediated alterations in coagulation, leukocyte and monocyte migration, smooth muscle growth, lipoprotein uptake and metabolism, and endothelial cell survival. We also propose a model of signal transduction for the endothelial cell response to shear stress including possible mechanotransducers (integrins, caveolae, ion channels, and G proteins), intermediate signaling molecules (c-Src, ras, Raf, protein kinase C) and the mitogen activated protein kinases (ERK1/2, JNK, p38, BMK-1), and effector molecules (nitric oxide). The endothelial cell response to shear stress may also provide a mechanism by which risk factors such as hypertension, diabetes, hypercholesterolemia, and sedentary lifestyle act to promote atherosclerosis.

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Metadata

Authors
Traub, O., & Berk, B. C.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-05
Volume
18
Issue
5
Pages
677-685
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/01.atv.18.5.677
OpenAlex
W2147367812
Cited by
1,085
References
82
FWCI
10.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force. https://app.cochat.ai/papers/10.1161/01.atv.18.5.677
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Traub, O., & Berk, B. C. (1998). Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.18.5.677

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.